Formulation development of novel in situ nanoemulgel (NEG) of ketoprofen for the treatment of periodontitis

The aim of the present study was to formulate and evaluate in situ gelling syringeable nanoemulgels (NEGs) of ketoprofen for periodontal delivery. Application of 3-factor 3-level design was employed using the Box-Behnken experimental design for the optimization of nanoemulsion using three independen...

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Veröffentlicht in:	Drug delivery 2016-01, Vol.23 (1), p.154-166
Hauptverfasser:	Srivastava, M., Kohli, K., Ali, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Box-Behnken experimental design Chemistry, Pharmaceutical Drug Delivery Systems Drug Stability Emulsions Gels Goats - metabolism HET-CAM method, ketoprofen Ketoprofen - administration & dosage Ketoprofen - therapeutic use Mouth Mucosa - metabolism mucoadhesion nanoemulgel Nanostructures Particle Size Periodontitis - drug therapy Surface-Active Agents
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