Total Synthesis and Biological Assessment of Mandelalide A

A new convergent total synthesis of the marine macrolide mandelalide A (1) has been developed that is based on macrocyclic ring closure by a Shiina‐type macrolactonization and the construction of the requisite precursor seco acid by a highly efficient Sonogashira cross‐coupling reaction between two...

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Veröffentlicht in:	Chemistry : a European journal 2016-01, Vol.22 (4), p.1292-1300
Hauptverfasser:	Brütsch, Tobias Michael, Bucher, Pascal, Altmann, Karl-Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Biological Factors cancer Catalysis Cell Line, Tumor Humans Lung Neoplasms - chemistry Lung Neoplasms - metabolism Lung Neoplasms - pathology macrolactonization Macrolides - chemical synthesis Macrolides - chemistry Macrolides - pharmacology mandelalide marine natural products Molecular Structure Stereoisomerism total synthesis
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