High-fat diet increases vulnerability to atrial arrhythmia by conduction disturbance via miR-27b

Abstract Background Lifestyle-related diseases, such as obesity and dyslipidemia are important risk factors for atrial fibrillation (AF). However, the underlying mechanism linking these diseases and AF has not been fully investigated. Methods Adult male mice were fed a high-fat diet (HFD) or vehicle...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular and cellular cardiology 2016-01, Vol.90, p.38-46
Hauptverfasser:	Takahashi, Kentaro, Sasano, Tetsuo, Sugiyama, Koji, Kurokawa, Junko, Tamura, Noriko, Soejima, Yurie, Sawabe, Motoji, Isobe, Mitsuaki, Furukawa, Tetsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Arrhythmia, Sinus - etiology Arrhythmia, Sinus - genetics Arrhythmia, Sinus - metabolism Arrhythmia, Sinus - pathology Atrial fibrillation Brugada Syndrome - etiology Brugada Syndrome - genetics Brugada Syndrome - metabolism Brugada Syndrome - pathology Cardiac Conduction System Disease Cardiovascular Cell Line Connexins - genetics Connexins - metabolism Diet, High-Fat - adverse effects Electrical remodeling Gap junction Gap Junction alpha-5 Protein Gene Expression Regulation Heart Atria - metabolism Heart Atria - pathology HEK293 Cells Humans Lipids Male Mice Mice, Inbred C57BL MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Oligonucleotide Array Sequence Analysis Organ Culture Techniques Palmitic Acid - pharmacology Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!