Age-dependency of glycosaminoglycan content in lumbar discs: A 3t gagcEST study
Purpose To analyze age‐dependency of glycosaminoglycan content using gagCEST (glycosaminoglycan chemical exchange saturation transfer) imaging in lumbar intervertebral discs of healthy volunteers. Materials and Methods In all, 70 volunteers without low back pain (mean age 44 ± 14 years, range: 21–69...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2015-12, Vol.42 (6), p.1517-1523 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Müller-Lutz, Anja Schleich, Christoph Pentang, Gael Schmitt, Benjamin Lanzman, Rotem S. Matuschke, Felix Wittsack, Hans-Jörg Miese, Falk |
| description | Purpose
To analyze age‐dependency of glycosaminoglycan content using gagCEST (glycosaminoglycan chemical exchange saturation transfer) imaging in lumbar intervertebral discs of healthy volunteers.
Materials and Methods
In all, 70 volunteers without low back pain (mean age 44 ± 14 years, range: 21–69 years) were examined with T2‐weighted and gagCEST imaging with a 3T MR scanner, with approval of the local Ethics Committee after written informed consent was obtained. Pfirrmann grading and classification into discs without bulging and herniation, discs with bulging, and discs with herniation were performed. Only intervertebral discs without bulging and herniation were analyzed. A region‐of‐interest‐based gagCEST analysis of nucleus pulposus (NP) and annulus fibrosus (AF) was performed. Correlation between age and gagCEST was tested within groups of equal Pfirrmann score.
Results
GagCEST effects decreased significantly from 3.09 ± 1.12% in 20–29 years old volunteers to −0.24 ± 1.36% in 50–59 years old volunteers (P |
| doi_str_mv | 10.1002/jmri.24945 |
| format | Article |
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To analyze age‐dependency of glycosaminoglycan content using gagCEST (glycosaminoglycan chemical exchange saturation transfer) imaging in lumbar intervertebral discs of healthy volunteers.
Materials and Methods
In all, 70 volunteers without low back pain (mean age 44 ± 14 years, range: 21–69 years) were examined with T2‐weighted and gagCEST imaging with a 3T MR scanner, with approval of the local Ethics Committee after written informed consent was obtained. Pfirrmann grading and classification into discs without bulging and herniation, discs with bulging, and discs with herniation were performed. Only intervertebral discs without bulging and herniation were analyzed. A region‐of‐interest‐based gagCEST analysis of nucleus pulposus (NP) and annulus fibrosus (AF) was performed. Correlation between age and gagCEST was tested within groups of equal Pfirrmann score.
Results
GagCEST effects decreased significantly from 3.09 ± 1.12% in 20–29 years old volunteers to −0.24 ± 1.36% in 50–59 years old volunteers (P < 0.001). In the case of Pfirrmann scores 2 and 3, a significant correlation was observed between gagCEST effect and age (Pfirrmann score 2, NP: ρ = –0.558, P < 0.001; Pfirrmann score 3, NP: ρ = –0.337, P = 0.048). For Pfirrmann scores 1 and 4, no significant correlation was obtained (Pfirrmann score 1, NP: ρ = –0.046, P = 0.824; Pfirrmann score 4, NP: ρ = –0.316, P = 0.188).
Conclusion
We show a decreased gagCEST effect likely corresponding to decreasing glycosaminoglycans with aging. Hence, age‐matched analysis of gagCEST imaging may be necessary in future studies. J. MAGN. RESON. IMAGING 2015;42:1517–1523.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.24945</identifier><identifier>PMID: 25970563</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Age ; Aged ; Aging - metabolism ; Aging - pathology ; chemical exchange saturation transfer (CEST) ; Female ; glycosaminoglycans ; Glycosaminoglycans - metabolism ; Humans ; Image Interpretation, Computer-Assisted - methods ; intervertebral disc ; Intervertebral Disc - anatomy & histology ; Intervertebral Disc - metabolism ; Lumbar Vertebrae - anatomy & histology ; Lumbar Vertebrae - metabolism ; Magnetic resonance imaging ; magnetic resonance imaging (MRI) ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Spectroscopy - methods ; Male ; Middle Aged ; Molecular Imaging - methods ; Reproducibility of Results ; Sensitivity and Specificity ; Tissue Distribution ; Young Adult</subject><ispartof>Journal of magnetic resonance imaging, 2015-12, Vol.42 (6), p.1517-1523</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5185-8ef39357b6813f23a928f97d326ee05dd43c5bc910ea9fd2bccf8a7a9052dae53</citedby><cites>FETCH-LOGICAL-c5185-8ef39357b6813f23a928f97d326ee05dd43c5bc910ea9fd2bccf8a7a9052dae53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.24945$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.24945$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25970563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Müller-Lutz, Anja</creatorcontrib><creatorcontrib>Schleich, Christoph</creatorcontrib><creatorcontrib>Pentang, Gael</creatorcontrib><creatorcontrib>Schmitt, Benjamin</creatorcontrib><creatorcontrib>Lanzman, Rotem S.</creatorcontrib><creatorcontrib>Matuschke, Felix</creatorcontrib><creatorcontrib>Wittsack, Hans-Jörg</creatorcontrib><creatorcontrib>Miese, Falk</creatorcontrib><title>Age-dependency of glycosaminoglycan content in lumbar discs: A 3t gagcEST study</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To analyze age‐dependency of glycosaminoglycan content using gagCEST (glycosaminoglycan chemical exchange saturation transfer) imaging in lumbar intervertebral discs of healthy volunteers.
Materials and Methods
In all, 70 volunteers without low back pain (mean age 44 ± 14 years, range: 21–69 years) were examined with T2‐weighted and gagCEST imaging with a 3T MR scanner, with approval of the local Ethics Committee after written informed consent was obtained. Pfirrmann grading and classification into discs without bulging and herniation, discs with bulging, and discs with herniation were performed. Only intervertebral discs without bulging and herniation were analyzed. A region‐of‐interest‐based gagCEST analysis of nucleus pulposus (NP) and annulus fibrosus (AF) was performed. Correlation between age and gagCEST was tested within groups of equal Pfirrmann score.
Results
GagCEST effects decreased significantly from 3.09 ± 1.12% in 20–29 years old volunteers to −0.24 ± 1.36% in 50–59 years old volunteers (P < 0.001). In the case of Pfirrmann scores 2 and 3, a significant correlation was observed between gagCEST effect and age (Pfirrmann score 2, NP: ρ = –0.558, P < 0.001; Pfirrmann score 3, NP: ρ = –0.337, P = 0.048). For Pfirrmann scores 1 and 4, no significant correlation was obtained (Pfirrmann score 1, NP: ρ = –0.046, P = 0.824; Pfirrmann score 4, NP: ρ = –0.316, P = 0.188).
Conclusion
We show a decreased gagCEST effect likely corresponding to decreasing glycosaminoglycans with aging. Hence, age‐matched analysis of gagCEST imaging may be necessary in future studies. J. MAGN. RESON. IMAGING 2015;42:1517–1523.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aging - metabolism</subject><subject>Aging - pathology</subject><subject>chemical exchange saturation transfer (CEST)</subject><subject>Female</subject><subject>glycosaminoglycans</subject><subject>Glycosaminoglycans - metabolism</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>intervertebral disc</subject><subject>Intervertebral Disc - anatomy & histology</subject><subject>Intervertebral Disc - metabolism</subject><subject>Lumbar Vertebrae - anatomy & histology</subject><subject>Lumbar Vertebrae - metabolism</subject><subject>Magnetic resonance imaging</subject><subject>magnetic resonance imaging (MRI)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Imaging - methods</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Tissue Distribution</subject><subject>Young Adult</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1P3DAQBmALURVKe-kPqCxxqSqF-mNtx9y2iK9qAakFIXGxHHuyypI4WztRyb-vtwsceuhp5vDMq9GL0EdKjigh7Ouqi80Rm-mZ2EH7VDBWMFHK3bwTwQtaErWH3qW0IoTojN6iPSa0IkLyfXQzX0LhYQ3BQ3AT7mu8bCfXJ9s1od-sNmDXhwHCgJuA27GrbMS-SS4d4znmA17apTv9eYvTMPrpPXpT2zbBh-d5gO7OTm9PLorFzfnlyXxROEFLUZRQc82FqmRJec241aystfKcSQAivJ9xJyqnKQGra88q5-rSKquJYN6C4Afo8zZ3HftfI6TBdPklaFsboB-ToUqSUoqZ5pke_kNX_RhD_i4roQSTUqmsvmyVi31KEWqzjk1n42QoMZuazaZm87fmjD89R45VB_6VvvSaAd2C300L03-izPerH5cvocX2pkkDPL3e2PhopOJKmPvr83x-sVhcfXsw1_wPt3GWAA</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Müller-Lutz, Anja</creator><creator>Schleich, Christoph</creator><creator>Pentang, Gael</creator><creator>Schmitt, Benjamin</creator><creator>Lanzman, Rotem S.</creator><creator>Matuschke, Felix</creator><creator>Wittsack, Hans-Jörg</creator><creator>Miese, Falk</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Age-dependency of glycosaminoglycan content in lumbar discs: A 3t gagcEST study</title><author>Müller-Lutz, Anja ; Schleich, Christoph ; Pentang, Gael ; Schmitt, Benjamin ; Lanzman, Rotem S. ; Matuschke, Felix ; Wittsack, Hans-Jörg ; Miese, Falk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5185-8ef39357b6813f23a928f97d326ee05dd43c5bc910ea9fd2bccf8a7a9052dae53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aging - metabolism</topic><topic>Aging - pathology</topic><topic>chemical exchange saturation transfer (CEST)</topic><topic>Female</topic><topic>glycosaminoglycans</topic><topic>Glycosaminoglycans - metabolism</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>intervertebral disc</topic><topic>Intervertebral Disc - anatomy & histology</topic><topic>Intervertebral Disc - metabolism</topic><topic>Lumbar Vertebrae - anatomy & histology</topic><topic>Lumbar Vertebrae - metabolism</topic><topic>Magnetic resonance imaging</topic><topic>magnetic resonance imaging (MRI)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Imaging - methods</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Tissue Distribution</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Müller-Lutz, Anja</creatorcontrib><creatorcontrib>Schleich, Christoph</creatorcontrib><creatorcontrib>Pentang, Gael</creatorcontrib><creatorcontrib>Schmitt, Benjamin</creatorcontrib><creatorcontrib>Lanzman, Rotem S.</creatorcontrib><creatorcontrib>Matuschke, Felix</creatorcontrib><creatorcontrib>Wittsack, Hans-Jörg</creatorcontrib><creatorcontrib>Miese, Falk</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Müller-Lutz, Anja</au><au>Schleich, Christoph</au><au>Pentang, Gael</au><au>Schmitt, Benjamin</au><au>Lanzman, Rotem S.</au><au>Matuschke, Felix</au><au>Wittsack, Hans-Jörg</au><au>Miese, Falk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-dependency of glycosaminoglycan content in lumbar discs: A 3t gagcEST study</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2015-12</date><risdate>2015</risdate><volume>42</volume><issue>6</issue><spage>1517</spage><epage>1523</epage><pages>1517-1523</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To analyze age‐dependency of glycosaminoglycan content using gagCEST (glycosaminoglycan chemical exchange saturation transfer) imaging in lumbar intervertebral discs of healthy volunteers.
Materials and Methods
In all, 70 volunteers without low back pain (mean age 44 ± 14 years, range: 21–69 years) were examined with T2‐weighted and gagCEST imaging with a 3T MR scanner, with approval of the local Ethics Committee after written informed consent was obtained. Pfirrmann grading and classification into discs without bulging and herniation, discs with bulging, and discs with herniation were performed. Only intervertebral discs without bulging and herniation were analyzed. A region‐of‐interest‐based gagCEST analysis of nucleus pulposus (NP) and annulus fibrosus (AF) was performed. Correlation between age and gagCEST was tested within groups of equal Pfirrmann score.
Results
GagCEST effects decreased significantly from 3.09 ± 1.12% in 20–29 years old volunteers to −0.24 ± 1.36% in 50–59 years old volunteers (P < 0.001). In the case of Pfirrmann scores 2 and 3, a significant correlation was observed between gagCEST effect and age (Pfirrmann score 2, NP: ρ = –0.558, P < 0.001; Pfirrmann score 3, NP: ρ = –0.337, P = 0.048). For Pfirrmann scores 1 and 4, no significant correlation was obtained (Pfirrmann score 1, NP: ρ = –0.046, P = 0.824; Pfirrmann score 4, NP: ρ = –0.316, P = 0.188).
Conclusion
We show a decreased gagCEST effect likely corresponding to decreasing glycosaminoglycans with aging. Hence, age‐matched analysis of gagCEST imaging may be necessary in future studies. J. MAGN. RESON. IMAGING 2015;42:1517–1523.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25970563</pmid><doi>10.1002/jmri.24945</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Aging - metabolism Aging - pathology chemical exchange saturation transfer (CEST) Female glycosaminoglycans Glycosaminoglycans - metabolism Humans Image Interpretation, Computer-Assisted - methods intervertebral disc Intervertebral Disc - anatomy & histology Intervertebral Disc - metabolism Lumbar Vertebrae - anatomy & histology Lumbar Vertebrae - metabolism Magnetic resonance imaging magnetic resonance imaging (MRI) Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Male Middle Aged Molecular Imaging - methods Reproducibility of Results Sensitivity and Specificity Tissue Distribution Young Adult |
| title | Age-dependency of glycosaminoglycan content in lumbar discs: A 3t gagcEST study |
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