Using GWAS to identify genetic predisposition in hepatic autoimmunity

Abstract Primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) represent the three major hepatic autoimmune conditions. Patient morbidity and mortality remain high across these three diseases, and an unmet need for rational therapy exists. Disease under...

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Veröffentlicht in:	Journal of autoimmunity 2016-01, Vol.66, p.25-39
Hauptverfasser:	Webb, G.J, Hirschfield, G.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Allergy and Immunology Autoimmune hepatitis Autoimmunity - genetics Biliary autoimmunity CD28 Antigens - genetics CD28 Antigens - metabolism Cholangitis, Sclerosing - genetics Cholangitis, Sclerosing - immunology Epigenetics Epistasis Epistasis, Genetic Fucosyltransferases - genetics Fucosyltransferases - immunology Galactoside 2-alpha-L-fucosyltransferase Genetic Predisposition to Disease Genetic risk Genome-Wide Association Study Haplotypes Hepatitis, Autoimmune - genetics Hepatitis, Autoimmune - immunology Heritability HLA Antigens - genetics Humans Immune regulation Interleukin-12 - genetics Interleukin-12 - metabolism Interleukin-2 - genetics Interleukin-2 - metabolism Intracellular Signaling Peptides and Proteins Liver - immunology Liver Cirrhosis, Biliary - genetics Liver Cirrhosis, Biliary - immunology Polymorphism, Single Nucleotide Primary biliary cirrhosis Primary sclerosing cholangitis Proteins - genetics Proteins - immunology Risk Factors Signal Transduction - immunology STAT4 Transcription Factor - genetics STAT4 Transcription Factor - metabolism
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