Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1 to 3

The zebrafish (Danio rerio) has been increasingly explored in pharmaceutical research as a promising alternative model for toxicological screens. This necessitates a thorough knowledge on the biotransformation processes for a correct interpretation of pharmacological and toxicological data. Physiolo...

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Veröffentlicht in:	Journal of toxicological sciences 2016/02/01, Vol.41(1), pp.1-11
Hauptverfasser:	Saad, Moayad, Cavanaugh, Kate, Verbueken, Evy, Pype, Casper, Casteleyn, Christophe, Ginneken, Chris Van, Cruchten, Steven Van
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotransformation Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Evolution, Molecular Gene Ontology Humans Isoenzymes - genetics Isoenzymes - metabolism Ontogeny Synteny Xenobiotics Xenobiotics - metabolism Zebrafish Zebrafish - metabolism
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