Combined effect of Hashimoto's thyroiditis and BRAF(V600E) mutation status on aggressiveness in papillary thyroid cancer
The purpose of this study was to evaluate the association between Hashimoto's thyroiditis and BRAF(V600E) mutation status in patients with papillary thyroid cancer (PTC) and to determine their combined association with tumor aggressiveness in PTC. A total of 1780 patients with PTC who underwent...
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Veröffentlicht in: | Head & neck 2016-01, Vol.38 (1), p.95-101 |
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creator | Kim, Su-jin Myong, Jun Pyo Jee, Hyeon-Gun Chai, Young Jun Choi, June Young Min, Hye Sook Lee, Kyu Eun Youn, Yeo-Kyu |
description | The purpose of this study was to evaluate the association between Hashimoto's thyroiditis and BRAF(V600E) mutation status in patients with papillary thyroid cancer (PTC) and to determine their combined association with tumor aggressiveness in PTC.
A total of 1780 patients with PTC who underwent surgery were enrolled in this study. Simple and multiple analyses were performed to determine the association between Hashimoto's thyroiditis and the BRAF(V600E) mutation in PTC.
Hashimoto's thyroiditis was present in 11.5% of patients (204/1780) with PTC. Multiple logistic regressions showed that BRAF(V600E) (odds ratio [OR] = 0.493; 95% confidence interval [CI] = 0.360-0.678) and the female sex (OR = 7.146; 95% CI = 3.408-18.347) were independent factors associated with Hashimoto's thyroiditis in PTC. BRAF(V600E) mutation and the Hashimoto's thyroiditis-negative PTC group were associated with aggressive disease (OR = 3.069; 95% CI = 1.654-5.916).
Hashimoto's thyroiditis was associated less frequently with BRAF(V600E) , and frequently with the female sex in patients with PTC. Hashimoto's thyroiditis and BRAF(V600E) status may help to predict clinical outcome of PTC. |
doi_str_mv | 10.1002/hed.23854 |
format | Article |
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A total of 1780 patients with PTC who underwent surgery were enrolled in this study. Simple and multiple analyses were performed to determine the association between Hashimoto's thyroiditis and the BRAF(V600E) mutation in PTC.
Hashimoto's thyroiditis was present in 11.5% of patients (204/1780) with PTC. Multiple logistic regressions showed that BRAF(V600E) (odds ratio [OR] = 0.493; 95% confidence interval [CI] = 0.360-0.678) and the female sex (OR = 7.146; 95% CI = 3.408-18.347) were independent factors associated with Hashimoto's thyroiditis in PTC. BRAF(V600E) mutation and the Hashimoto's thyroiditis-negative PTC group were associated with aggressive disease (OR = 3.069; 95% CI = 1.654-5.916).
Hashimoto's thyroiditis was associated less frequently with BRAF(V600E) , and frequently with the female sex in patients with PTC. Hashimoto's thyroiditis and BRAF(V600E) status may help to predict clinical outcome of PTC.</description><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23854</identifier><identifier>PMID: 25213729</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - genetics ; Carcinoma - genetics ; Carcinoma - surgery ; Carcinoma, Papillary ; Female ; Hashimoto Disease - genetics ; Hashimoto Disease - surgery ; Humans ; Middle Aged ; Mutation ; Neoplasm Invasiveness ; Predictive Value of Tests ; Prognosis ; Proto-Oncogene Proteins B-raf - genetics ; Risk Factors ; Sensitivity and Specificity ; Thyroid Cancer, Papillary ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - surgery ; Treatment Outcome</subject><ispartof>Head & neck, 2016-01, Vol.38 (1), p.95-101</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c251t-7323e7ffd8c7a979182365e2055f4b589bf4a35e2bc6d53124748319ee72dcbd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25213729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Su-jin</creatorcontrib><creatorcontrib>Myong, Jun Pyo</creatorcontrib><creatorcontrib>Jee, Hyeon-Gun</creatorcontrib><creatorcontrib>Chai, Young Jun</creatorcontrib><creatorcontrib>Choi, June Young</creatorcontrib><creatorcontrib>Min, Hye Sook</creatorcontrib><creatorcontrib>Lee, Kyu Eun</creatorcontrib><creatorcontrib>Youn, Yeo-Kyu</creatorcontrib><title>Combined effect of Hashimoto's thyroiditis and BRAF(V600E) mutation status on aggressiveness in papillary thyroid cancer</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>The purpose of this study was to evaluate the association between Hashimoto's thyroiditis and BRAF(V600E) mutation status in patients with papillary thyroid cancer (PTC) and to determine their combined association with tumor aggressiveness in PTC.
A total of 1780 patients with PTC who underwent surgery were enrolled in this study. Simple and multiple analyses were performed to determine the association between Hashimoto's thyroiditis and the BRAF(V600E) mutation in PTC.
Hashimoto's thyroiditis was present in 11.5% of patients (204/1780) with PTC. Multiple logistic regressions showed that BRAF(V600E) (odds ratio [OR] = 0.493; 95% confidence interval [CI] = 0.360-0.678) and the female sex (OR = 7.146; 95% CI = 3.408-18.347) were independent factors associated with Hashimoto's thyroiditis in PTC. BRAF(V600E) mutation and the Hashimoto's thyroiditis-negative PTC group were associated with aggressive disease (OR = 3.069; 95% CI = 1.654-5.916).
Hashimoto's thyroiditis was associated less frequently with BRAF(V600E) , and frequently with the female sex in patients with PTC. Hashimoto's thyroiditis and BRAF(V600E) status may help to predict clinical outcome of PTC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - surgery</subject><subject>Carcinoma, Papillary</subject><subject>Female</subject><subject>Hashimoto Disease - genetics</subject><subject>Hashimoto Disease - surgery</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Neoplasm Invasiveness</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins B-raf - genetics</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Thyroid Cancer, Papillary</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Treatment Outcome</subject><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM9LwzAcxYMgbk4P_gOSm_PQmR9N0x7n2JwwEES9ljT5ZousTW3S4f57C26nz-PxeDweQneUzCgh7GkHZsZ4LtILNKakkAnhqRyh6xC-CSE8S9kVGjHBKJesGKPfha8r14DBYC3oiL3FaxV2rvbRPwQcd8fOO-OiC1g1Bj-_z1fTr4yQ5SOu-6ii8w0OA_uAB6W22w5CcAdoBmDX4Fa1br9X3fFchbVqNHQ36NKqfYDbEyfoc7X8WKyTzdvL62K-STQTNCaSMw7SWpNrqQpZ0JzxTAAjQti0EnlR2VTxwah0ZgSnLJVpzmkBIJnRleETNP3vbTv_00OIZe2ChmFSA74PJZUZyTNacDJE70_RvqrBlG3n6mF4eX6L_wEoBmmT</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Kim, Su-jin</creator><creator>Myong, Jun Pyo</creator><creator>Jee, Hyeon-Gun</creator><creator>Chai, Young Jun</creator><creator>Choi, June Young</creator><creator>Min, Hye Sook</creator><creator>Lee, Kyu Eun</creator><creator>Youn, Yeo-Kyu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201601</creationdate><title>Combined effect of Hashimoto's thyroiditis and BRAF(V600E) mutation status on aggressiveness in papillary thyroid cancer</title><author>Kim, Su-jin ; Myong, Jun Pyo ; Jee, Hyeon-Gun ; Chai, Young Jun ; Choi, June Young ; Min, Hye Sook ; Lee, Kyu Eun ; Youn, Yeo-Kyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c251t-7323e7ffd8c7a979182365e2055f4b589bf4a35e2bc6d53124748319ee72dcbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - surgery</topic><topic>Carcinoma, Papillary</topic><topic>Female</topic><topic>Hashimoto Disease - genetics</topic><topic>Hashimoto Disease - surgery</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Neoplasm Invasiveness</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins B-raf - genetics</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Thyroid Cancer, Papillary</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Su-jin</creatorcontrib><creatorcontrib>Myong, Jun Pyo</creatorcontrib><creatorcontrib>Jee, Hyeon-Gun</creatorcontrib><creatorcontrib>Chai, Young Jun</creatorcontrib><creatorcontrib>Choi, June Young</creatorcontrib><creatorcontrib>Min, Hye Sook</creatorcontrib><creatorcontrib>Lee, Kyu Eun</creatorcontrib><creatorcontrib>Youn, Yeo-Kyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Su-jin</au><au>Myong, Jun Pyo</au><au>Jee, Hyeon-Gun</au><au>Chai, Young Jun</au><au>Choi, June Young</au><au>Min, Hye Sook</au><au>Lee, Kyu Eun</au><au>Youn, Yeo-Kyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined effect of Hashimoto's thyroiditis and BRAF(V600E) mutation status on aggressiveness in papillary thyroid cancer</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2016-01</date><risdate>2016</risdate><volume>38</volume><issue>1</issue><spage>95</spage><epage>101</epage><pages>95-101</pages><eissn>1097-0347</eissn><abstract>The purpose of this study was to evaluate the association between Hashimoto's thyroiditis and BRAF(V600E) mutation status in patients with papillary thyroid cancer (PTC) and to determine their combined association with tumor aggressiveness in PTC.
A total of 1780 patients with PTC who underwent surgery were enrolled in this study. Simple and multiple analyses were performed to determine the association between Hashimoto's thyroiditis and the BRAF(V600E) mutation in PTC.
Hashimoto's thyroiditis was present in 11.5% of patients (204/1780) with PTC. Multiple logistic regressions showed that BRAF(V600E) (odds ratio [OR] = 0.493; 95% confidence interval [CI] = 0.360-0.678) and the female sex (OR = 7.146; 95% CI = 3.408-18.347) were independent factors associated with Hashimoto's thyroiditis in PTC. BRAF(V600E) mutation and the Hashimoto's thyroiditis-negative PTC group were associated with aggressive disease (OR = 3.069; 95% CI = 1.654-5.916).
Hashimoto's thyroiditis was associated less frequently with BRAF(V600E) , and frequently with the female sex in patients with PTC. Hashimoto's thyroiditis and BRAF(V600E) status may help to predict clinical outcome of PTC.</abstract><cop>United States</cop><pmid>25213729</pmid><doi>10.1002/hed.23854</doi><tpages>7</tpages></addata></record> |
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subjects | Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Carcinoma - genetics Carcinoma - surgery Carcinoma, Papillary Female Hashimoto Disease - genetics Hashimoto Disease - surgery Humans Middle Aged Mutation Neoplasm Invasiveness Predictive Value of Tests Prognosis Proto-Oncogene Proteins B-raf - genetics Risk Factors Sensitivity and Specificity Thyroid Cancer, Papillary Thyroid Neoplasms - genetics Thyroid Neoplasms - surgery Treatment Outcome |
title | Combined effect of Hashimoto's thyroiditis and BRAF(V600E) mutation status on aggressiveness in papillary thyroid cancer |
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