Axon-First Neuritogenesis on Vertical Nanowires
In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarizati...
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| Veröffentlicht in: | Nano letters 2016-01, Vol.16 (1), p.675-680 |
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| container_end_page | 680 |
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| container_issue | 1 |
| container_start_page | 675 |
| container_title | Nano letters |
| container_volume | 16 |
| creator | Kang, Kyungtae Park, Yi-Seul Park, Matthew Jang, Min Jee Kim, Seong-Min Lee, Juno Choi, Ji Yu Jung, Da Hee Chang, Young-Tae Yoon, Myung-Han Lee, Jin Seok Nam, Yoonkey Choi, Insung S |
| description | In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo. |
| doi_str_mv | 10.1021/acs.nanolett.5b04458 |
| format | Article |
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The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo.</description><identifier>ISSN: 1530-6984</identifier><identifier>EISSN: 1530-6992</identifier><identifier>DOI: 10.1021/acs.nanolett.5b04458</identifier><identifier>PMID: 26645112</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Actins - chemistry ; Animals ; Axons - chemistry ; Axons - physiology ; Cell Culture Techniques ; Cell Tracking - methods ; Hippocampus - chemistry ; Hippocampus - cytology ; Nanowires - chemistry ; Neurites - chemistry ; Neurogenesis ; Rats ; Silicon - chemistry</subject><ispartof>Nano letters, 2016-01, Vol.16 (1), p.675-680</ispartof><rights>Copyright © 2015 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a348t-f4c7f57ca0c5ac68bb0c791fa99caca5dae7aeb2b626847673fb9484e3ea79a63</citedby><cites>FETCH-LOGICAL-a348t-f4c7f57ca0c5ac68bb0c791fa99caca5dae7aeb2b626847673fb9484e3ea79a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.nanolett.5b04458$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.nanolett.5b04458$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,777,781,2752,27057,27905,27906,56719,56769</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26645112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Kyungtae</creatorcontrib><creatorcontrib>Park, Yi-Seul</creatorcontrib><creatorcontrib>Park, Matthew</creatorcontrib><creatorcontrib>Jang, Min Jee</creatorcontrib><creatorcontrib>Kim, Seong-Min</creatorcontrib><creatorcontrib>Lee, Juno</creatorcontrib><creatorcontrib>Choi, Ji Yu</creatorcontrib><creatorcontrib>Jung, Da Hee</creatorcontrib><creatorcontrib>Chang, Young-Tae</creatorcontrib><creatorcontrib>Yoon, Myung-Han</creatorcontrib><creatorcontrib>Lee, Jin Seok</creatorcontrib><creatorcontrib>Nam, Yoonkey</creatorcontrib><creatorcontrib>Choi, Insung S</creatorcontrib><title>Axon-First Neuritogenesis on Vertical Nanowires</title><title>Nano letters</title><addtitle>Nano Lett</addtitle><description>In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. 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| source | MEDLINE; ACS Publications |
| subjects | Actins - chemistry Animals Axons - chemistry Axons - physiology Cell Culture Techniques Cell Tracking - methods Hippocampus - chemistry Hippocampus - cytology Nanowires - chemistry Neurites - chemistry Neurogenesis Rats Silicon - chemistry |
| title | Axon-First Neuritogenesis on Vertical Nanowires |
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