Comparison between alcohol‐ and hepatitis C virus‐related hepatocellular carcinoma: clinical presentation, treatment and outcome
Summary Background Hepatitis C virus (HCV) and alcohol abuse are the main risk factors for hepatocellular carcinoma (HCC) in Western countries. Aim To investigate the role of alcoholic aetiology on clinical presentation, treatment and outcome of HCC as well as on each Barcelona Clinic Liver Cancer (...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2016-02, Vol.43 (3), p.385-399 |
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| creator | Bucci, L. Garuti, F. Camelli, V. Lenzi, B. Farinati, F. Giannini, E. G. Ciccarese, F. Piscaglia, F. Rapaccini, G. L. Di Marco, M. Caturelli, E. Zoli, M. Borzio, F. Sacco, R. Maida, M. Felder, M. Morisco, F. Gasbarrini, A. Gemini, S. Foschi, F. G. Missale, G. Masotto, A. Affronti, A. Bernardi, M. Trevisani, F. Bolondi, Luigi Biselli, Maurizio Caraceni, Paolo Cucchetti, Alessandro Domenicali, Marco Gramenzi, Annagiulia Magalotti, Donatella Pecorelli, Anna Serra, Carla Venerandi, Laura Gazzola, Alessia Murer, Francesca Pozzan, Caterina Vanin, Veronica Poggio, Paolo Del Olmi, Stefano Balsamo, Claudia Vavassori, Elena Benvegnù, Luisa Capelli, Alberta Golfieri, Rita Mosconi, Cristina Renzulli, Matteo Roselli, Paola Isola, Serena Ialungo, Anna Maria Rastrelli, Elena Moscatelli, Alessandro Pelagatta, Gaia Picciotto, Antonino Savarino, Vincenzo Barcellona, Maria Rosa Cammà, Calogero Cabibbo, Giuseppe Costantino, Andrea Virdone, Roberto Mega, Andrea Rinninella, Emanuele Mismas, Valeria Dall'Aglio, Anna Chiara Feletti, Valentina Lanzi, Arianna Cappa, Federica Mirici Neri, Elga Stefanini, Giuseppe Francesco Tamberi, Stefano Biasini, Elisabetta Porro, Emanuela Guarino, Maria Baroni, Gianluca Svegliati Schiadà, Laura Chiaramonte, Maria Marchetti, Fabiana Valerio, Matteo |
| description | Summary
Background
Hepatitis C virus (HCV) and alcohol abuse are the main risk factors for hepatocellular carcinoma (HCC) in Western countries.
Aim
To investigate the role of alcoholic aetiology on clinical presentation, treatment and outcome of HCC as well as on each Barcelona Clinic Liver Cancer (BCLC) stage, as compared to HCV‐related HCCs.
Methods
A total of 1642 HCV and 573 alcoholic patients from the Italian Liver Cancer (ITA.LI.CA) database, diagnosed with HCC between January 2000 and December 2012 were compared for age, gender, type of diagnosis, tumour burden, portal vein thrombosis (PVT), oesophageal varices, liver function tests, alpha‐fetoprotein, BCLC, treatment and survival. Aetiology was tested as predictor of survival in multivariate Cox regression models and according to HCC stages.
Results
Cirrhosis was present in 96% of cases in both groups. Alcoholic patients were younger, more likely male, with HCC diagnosed outside surveillance, in intermediate/terminal BCLC stage and had worse liver function. After adjustment for the lead‐time, median (95% CI) overall survival (OS) was 27.4 months (21.5–33.2) in alcoholic and 33.6 months (30.7–36.5) in HCV patients (P = 0.021). The prognostic role of aetiology disappeared when survival was assessed in each BCLC stage and in the Cox regression multivariate models.
Conclusions
Alcoholic aetiology affects survival of HCC patients through its negative effects on secondary prevention and cancer presentation but not through a greater cancer aggressiveness or worse treatment result. In fact, survival adjusted for confounding factors was similar in alcoholic and HCV patients. |
| doi_str_mv | 10.1111/apt.13485 |
| format | Article |
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Background
Hepatitis C virus (HCV) and alcohol abuse are the main risk factors for hepatocellular carcinoma (HCC) in Western countries.
Aim
To investigate the role of alcoholic aetiology on clinical presentation, treatment and outcome of HCC as well as on each Barcelona Clinic Liver Cancer (BCLC) stage, as compared to HCV‐related HCCs.
Methods
A total of 1642 HCV and 573 alcoholic patients from the Italian Liver Cancer (ITA.LI.CA) database, diagnosed with HCC between January 2000 and December 2012 were compared for age, gender, type of diagnosis, tumour burden, portal vein thrombosis (PVT), oesophageal varices, liver function tests, alpha‐fetoprotein, BCLC, treatment and survival. Aetiology was tested as predictor of survival in multivariate Cox regression models and according to HCC stages.
Results
Cirrhosis was present in 96% of cases in both groups. Alcoholic patients were younger, more likely male, with HCC diagnosed outside surveillance, in intermediate/terminal BCLC stage and had worse liver function. After adjustment for the lead‐time, median (95% CI) overall survival (OS) was 27.4 months (21.5–33.2) in alcoholic and 33.6 months (30.7–36.5) in HCV patients (P = 0.021). The prognostic role of aetiology disappeared when survival was assessed in each BCLC stage and in the Cox regression multivariate models.
Conclusions
Alcoholic aetiology affects survival of HCC patients through its negative effects on secondary prevention and cancer presentation but not through a greater cancer aggressiveness or worse treatment result. In fact, survival adjusted for confounding factors was similar in alcoholic and HCV patients.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.13485</identifier><identifier>PMID: 26662476</identifier><language>eng</language><publisher>England</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; alpha-Fetoproteins - metabolism ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - mortality ; Esophageal and Gastric Varices - epidemiology ; Female ; Hepatitis C - complications ; Hepatitis C - epidemiology ; Hepatitis C - physiopathology ; Hepatitis, Alcoholic - complications ; Hepatitis, Alcoholic - epidemiology ; Hepatitis, Alcoholic - physiopathology ; Humans ; Liver Function Tests ; Liver Neoplasms - etiology ; Liver Neoplasms - mortality ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Sex Factors ; Treatment Outcome ; Venous Thrombosis - epidemiology</subject><ispartof>Alimentary pharmacology & therapeutics, 2016-02, Vol.43 (3), p.385-399</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4305-2797d62dcaa0a1a37c3b707241233900af48925bc6fd361a3d5759f7e9c331133</citedby><cites>FETCH-LOGICAL-c4305-2797d62dcaa0a1a37c3b707241233900af48925bc6fd361a3d5759f7e9c331133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.13485$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.13485$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26662476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bucci, L.</creatorcontrib><creatorcontrib>Garuti, F.</creatorcontrib><creatorcontrib>Camelli, V.</creatorcontrib><creatorcontrib>Lenzi, B.</creatorcontrib><creatorcontrib>Farinati, F.</creatorcontrib><creatorcontrib>Giannini, E. G.</creatorcontrib><creatorcontrib>Ciccarese, F.</creatorcontrib><creatorcontrib>Piscaglia, F.</creatorcontrib><creatorcontrib>Rapaccini, G. L.</creatorcontrib><creatorcontrib>Di Marco, M.</creatorcontrib><creatorcontrib>Caturelli, E.</creatorcontrib><creatorcontrib>Zoli, M.</creatorcontrib><creatorcontrib>Borzio, F.</creatorcontrib><creatorcontrib>Sacco, R.</creatorcontrib><creatorcontrib>Maida, M.</creatorcontrib><creatorcontrib>Felder, M.</creatorcontrib><creatorcontrib>Morisco, F.</creatorcontrib><creatorcontrib>Gasbarrini, A.</creatorcontrib><creatorcontrib>Gemini, S.</creatorcontrib><creatorcontrib>Foschi, F. G.</creatorcontrib><creatorcontrib>Missale, G.</creatorcontrib><creatorcontrib>Masotto, A.</creatorcontrib><creatorcontrib>Affronti, A.</creatorcontrib><creatorcontrib>Bernardi, M.</creatorcontrib><creatorcontrib>Trevisani, F.</creatorcontrib><creatorcontrib>Bolondi, Luigi</creatorcontrib><creatorcontrib>Biselli, Maurizio</creatorcontrib><creatorcontrib>Caraceni, Paolo</creatorcontrib><creatorcontrib>Cucchetti, Alessandro</creatorcontrib><creatorcontrib>Domenicali, Marco</creatorcontrib><creatorcontrib>Gramenzi, Annagiulia</creatorcontrib><creatorcontrib>Magalotti, Donatella</creatorcontrib><creatorcontrib>Pecorelli, Anna</creatorcontrib><creatorcontrib>Serra, Carla</creatorcontrib><creatorcontrib>Venerandi, Laura</creatorcontrib><creatorcontrib>Gazzola, Alessia</creatorcontrib><creatorcontrib>Murer, Francesca</creatorcontrib><creatorcontrib>Pozzan, Caterina</creatorcontrib><creatorcontrib>Vanin, Veronica</creatorcontrib><creatorcontrib>Poggio, Paolo Del</creatorcontrib><creatorcontrib>Olmi, Stefano</creatorcontrib><creatorcontrib>Balsamo, Claudia</creatorcontrib><creatorcontrib>Vavassori, Elena</creatorcontrib><creatorcontrib>Benvegnù, Luisa</creatorcontrib><creatorcontrib>Capelli, Alberta</creatorcontrib><creatorcontrib>Golfieri, Rita</creatorcontrib><creatorcontrib>Mosconi, Cristina</creatorcontrib><creatorcontrib>Renzulli, Matteo</creatorcontrib><creatorcontrib>Roselli, Paola</creatorcontrib><creatorcontrib>Isola, Serena</creatorcontrib><creatorcontrib>Ialungo, Anna Maria</creatorcontrib><creatorcontrib>Rastrelli, Elena</creatorcontrib><creatorcontrib>Moscatelli, Alessandro</creatorcontrib><creatorcontrib>Pelagatta, Gaia</creatorcontrib><creatorcontrib>Picciotto, Antonino</creatorcontrib><creatorcontrib>Savarino, Vincenzo</creatorcontrib><creatorcontrib>Barcellona, Maria Rosa</creatorcontrib><creatorcontrib>Cammà, Calogero</creatorcontrib><creatorcontrib>Cabibbo, Giuseppe</creatorcontrib><creatorcontrib>Costantino, Andrea</creatorcontrib><creatorcontrib>Virdone, Roberto</creatorcontrib><creatorcontrib>Mega, Andrea</creatorcontrib><creatorcontrib>Rinninella, Emanuele</creatorcontrib><creatorcontrib>Mismas, Valeria</creatorcontrib><creatorcontrib>Dall'Aglio, Anna Chiara</creatorcontrib><creatorcontrib>Feletti, Valentina</creatorcontrib><creatorcontrib>Lanzi, Arianna</creatorcontrib><creatorcontrib>Cappa, Federica Mirici</creatorcontrib><creatorcontrib>Neri, Elga</creatorcontrib><creatorcontrib>Stefanini, Giuseppe Francesco</creatorcontrib><creatorcontrib>Tamberi, Stefano</creatorcontrib><creatorcontrib>Biasini, Elisabetta</creatorcontrib><creatorcontrib>Porro, Emanuela</creatorcontrib><creatorcontrib>Guarino, Maria</creatorcontrib><creatorcontrib>Baroni, Gianluca Svegliati</creatorcontrib><creatorcontrib>Schiadà, Laura</creatorcontrib><creatorcontrib>Chiaramonte, Maria</creatorcontrib><creatorcontrib>Marchetti, Fabiana</creatorcontrib><creatorcontrib>Valerio, Matteo</creatorcontrib><creatorcontrib>Italian Liver Cancer ITA LI CA Group</creatorcontrib><creatorcontrib>Italian Liver Cancer (ITA.LI.CA) Group</creatorcontrib><creatorcontrib>the Italian Liver Cancer (ITA.LI.CA) Group</creatorcontrib><title>Comparison between alcohol‐ and hepatitis C virus‐related hepatocellular carcinoma: clinical presentation, treatment and outcome</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
Hepatitis C virus (HCV) and alcohol abuse are the main risk factors for hepatocellular carcinoma (HCC) in Western countries.
Aim
To investigate the role of alcoholic aetiology on clinical presentation, treatment and outcome of HCC as well as on each Barcelona Clinic Liver Cancer (BCLC) stage, as compared to HCV‐related HCCs.
Methods
A total of 1642 HCV and 573 alcoholic patients from the Italian Liver Cancer (ITA.LI.CA) database, diagnosed with HCC between January 2000 and December 2012 were compared for age, gender, type of diagnosis, tumour burden, portal vein thrombosis (PVT), oesophageal varices, liver function tests, alpha‐fetoprotein, BCLC, treatment and survival. Aetiology was tested as predictor of survival in multivariate Cox regression models and according to HCC stages.
Results
Cirrhosis was present in 96% of cases in both groups. Alcoholic patients were younger, more likely male, with HCC diagnosed outside surveillance, in intermediate/terminal BCLC stage and had worse liver function. After adjustment for the lead‐time, median (95% CI) overall survival (OS) was 27.4 months (21.5–33.2) in alcoholic and 33.6 months (30.7–36.5) in HCV patients (P = 0.021). The prognostic role of aetiology disappeared when survival was assessed in each BCLC stage and in the Cox regression multivariate models.
Conclusions
Alcoholic aetiology affects survival of HCC patients through its negative effects on secondary prevention and cancer presentation but not through a greater cancer aggressiveness or worse treatment result. In fact, survival adjusted for confounding factors was similar in alcoholic and HCV patients.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>alpha-Fetoproteins - metabolism</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Esophageal and Gastric Varices - epidemiology</subject><subject>Female</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - epidemiology</subject><subject>Hepatitis C - physiopathology</subject><subject>Hepatitis, Alcoholic - complications</subject><subject>Hepatitis, Alcoholic - epidemiology</subject><subject>Hepatitis, Alcoholic - physiopathology</subject><subject>Humans</subject><subject>Liver Function Tests</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Treatment Outcome</subject><subject>Venous Thrombosis - epidemiology</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtqGzEUhkVpqJ3LIi9QtGwhTnSZkTzZBdOkhUCySNbDseYMVtCMJpKmxrsu-gB9xjxJFNvNLkIgxP_xcc5PyCln5zyfCxjSOZfFvPxEplyqciaYVJ_JlAlVzcScywk5jPGJMaY0E1_IRCilRKHVlPxd-G6AYKPv6RLTGrGn4Ixfeffy5x-FvqErHCDZZCNd0N82jDEHAR0k3GfeoHOjg0ANBGN738ElNc721oCjQ8CIfcoK35_RFBBSl_9btR-T8R0ek4MWXMST_XtEHq9_PCx-zm7vbn4trm5nppAsb6Ur3SjRGAAGHKQ2cqmZFgUXUlaMQVvMK1EujWobqTLQlLqsWo2VkZJzKY_It513CP55xJjqzsa34aFHP8aaa8Xm25vR7zvUBB9jwLYegu0gbGrO6rfS61x6vS09s1_32nHZYfNO_m85Axc7YG0dbj421Vf3DzvlKzBrj3E</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Bucci, L.</creator><creator>Garuti, F.</creator><creator>Camelli, V.</creator><creator>Lenzi, B.</creator><creator>Farinati, F.</creator><creator>Giannini, E. G.</creator><creator>Ciccarese, F.</creator><creator>Piscaglia, F.</creator><creator>Rapaccini, G. L.</creator><creator>Di Marco, M.</creator><creator>Caturelli, E.</creator><creator>Zoli, M.</creator><creator>Borzio, F.</creator><creator>Sacco, R.</creator><creator>Maida, M.</creator><creator>Felder, M.</creator><creator>Morisco, F.</creator><creator>Gasbarrini, A.</creator><creator>Gemini, S.</creator><creator>Foschi, F. G.</creator><creator>Missale, G.</creator><creator>Masotto, A.</creator><creator>Affronti, A.</creator><creator>Bernardi, M.</creator><creator>Trevisani, F.</creator><creator>Bolondi, Luigi</creator><creator>Biselli, Maurizio</creator><creator>Caraceni, Paolo</creator><creator>Cucchetti, Alessandro</creator><creator>Domenicali, Marco</creator><creator>Gramenzi, Annagiulia</creator><creator>Magalotti, Donatella</creator><creator>Pecorelli, Anna</creator><creator>Serra, Carla</creator><creator>Venerandi, Laura</creator><creator>Gazzola, Alessia</creator><creator>Murer, Francesca</creator><creator>Pozzan, Caterina</creator><creator>Vanin, Veronica</creator><creator>Poggio, Paolo Del</creator><creator>Olmi, Stefano</creator><creator>Balsamo, Claudia</creator><creator>Vavassori, Elena</creator><creator>Benvegnù, Luisa</creator><creator>Capelli, Alberta</creator><creator>Golfieri, Rita</creator><creator>Mosconi, Cristina</creator><creator>Renzulli, Matteo</creator><creator>Roselli, Paola</creator><creator>Isola, Serena</creator><creator>Ialungo, Anna Maria</creator><creator>Rastrelli, Elena</creator><creator>Moscatelli, Alessandro</creator><creator>Pelagatta, Gaia</creator><creator>Picciotto, Antonino</creator><creator>Savarino, Vincenzo</creator><creator>Barcellona, Maria Rosa</creator><creator>Cammà, Calogero</creator><creator>Cabibbo, Giuseppe</creator><creator>Costantino, Andrea</creator><creator>Virdone, Roberto</creator><creator>Mega, Andrea</creator><creator>Rinninella, Emanuele</creator><creator>Mismas, Valeria</creator><creator>Dall'Aglio, Anna Chiara</creator><creator>Feletti, Valentina</creator><creator>Lanzi, Arianna</creator><creator>Cappa, Federica Mirici</creator><creator>Neri, Elga</creator><creator>Stefanini, Giuseppe Francesco</creator><creator>Tamberi, Stefano</creator><creator>Biasini, Elisabetta</creator><creator>Porro, Emanuela</creator><creator>Guarino, Maria</creator><creator>Baroni, Gianluca Svegliati</creator><creator>Schiadà, Laura</creator><creator>Chiaramonte, Maria</creator><creator>Marchetti, Fabiana</creator><creator>Valerio, Matteo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201602</creationdate><title>Comparison between alcohol‐ and hepatitis C virus‐related hepatocellular carcinoma: clinical presentation, treatment and outcome</title><author>Bucci, L. ; Garuti, F. ; Camelli, V. ; Lenzi, B. ; Farinati, F. ; Giannini, E. G. ; Ciccarese, F. ; Piscaglia, F. ; Rapaccini, G. L. ; Di Marco, M. ; Caturelli, E. ; Zoli, M. ; Borzio, F. ; Sacco, R. ; Maida, M. ; Felder, M. ; Morisco, F. ; Gasbarrini, A. ; Gemini, S. ; Foschi, F. G. ; Missale, G. ; Masotto, A. ; Affronti, A. ; Bernardi, M. ; Trevisani, F. ; Bolondi, Luigi ; Biselli, Maurizio ; Caraceni, Paolo ; Cucchetti, Alessandro ; Domenicali, Marco ; Gramenzi, Annagiulia ; Magalotti, Donatella ; Pecorelli, Anna ; Serra, Carla ; Venerandi, Laura ; Gazzola, Alessia ; Murer, Francesca ; Pozzan, Caterina ; Vanin, Veronica ; Poggio, Paolo Del ; Olmi, Stefano ; Balsamo, Claudia ; Vavassori, Elena ; Benvegnù, Luisa ; Capelli, Alberta ; Golfieri, Rita ; Mosconi, Cristina ; Renzulli, Matteo ; Roselli, Paola ; Isola, Serena ; Ialungo, Anna Maria ; Rastrelli, Elena ; Moscatelli, Alessandro ; Pelagatta, Gaia ; Picciotto, Antonino ; Savarino, Vincenzo ; Barcellona, Maria Rosa ; Cammà, Calogero ; Cabibbo, Giuseppe ; Costantino, Andrea ; Virdone, Roberto ; Mega, Andrea ; Rinninella, Emanuele ; Mismas, Valeria ; Dall'Aglio, Anna Chiara ; Feletti, Valentina ; Lanzi, Arianna ; Cappa, Federica Mirici ; Neri, Elga ; Stefanini, Giuseppe Francesco ; Tamberi, Stefano ; Biasini, Elisabetta ; Porro, Emanuela ; Guarino, Maria ; Baroni, Gianluca Svegliati ; Schiadà, Laura ; Chiaramonte, Maria ; Marchetti, Fabiana ; Valerio, Matteo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4305-2797d62dcaa0a1a37c3b707241233900af48925bc6fd361a3d5759f7e9c331133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>alpha-Fetoproteins - metabolism</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Esophageal and Gastric Varices - epidemiology</topic><topic>Female</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - epidemiology</topic><topic>Hepatitis C - physiopathology</topic><topic>Hepatitis, Alcoholic - complications</topic><topic>Hepatitis, Alcoholic - epidemiology</topic><topic>Hepatitis, Alcoholic - physiopathology</topic><topic>Humans</topic><topic>Liver Function Tests</topic><topic>Liver Neoplasms - etiology</topic><topic>Liver Neoplasms - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Treatment Outcome</topic><topic>Venous Thrombosis - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bucci, L.</creatorcontrib><creatorcontrib>Garuti, F.</creatorcontrib><creatorcontrib>Camelli, V.</creatorcontrib><creatorcontrib>Lenzi, B.</creatorcontrib><creatorcontrib>Farinati, F.</creatorcontrib><creatorcontrib>Giannini, E. G.</creatorcontrib><creatorcontrib>Ciccarese, F.</creatorcontrib><creatorcontrib>Piscaglia, F.</creatorcontrib><creatorcontrib>Rapaccini, G. L.</creatorcontrib><creatorcontrib>Di Marco, M.</creatorcontrib><creatorcontrib>Caturelli, E.</creatorcontrib><creatorcontrib>Zoli, M.</creatorcontrib><creatorcontrib>Borzio, F.</creatorcontrib><creatorcontrib>Sacco, R.</creatorcontrib><creatorcontrib>Maida, M.</creatorcontrib><creatorcontrib>Felder, M.</creatorcontrib><creatorcontrib>Morisco, F.</creatorcontrib><creatorcontrib>Gasbarrini, A.</creatorcontrib><creatorcontrib>Gemini, S.</creatorcontrib><creatorcontrib>Foschi, F. G.</creatorcontrib><creatorcontrib>Missale, G.</creatorcontrib><creatorcontrib>Masotto, A.</creatorcontrib><creatorcontrib>Affronti, A.</creatorcontrib><creatorcontrib>Bernardi, M.</creatorcontrib><creatorcontrib>Trevisani, F.</creatorcontrib><creatorcontrib>Bolondi, Luigi</creatorcontrib><creatorcontrib>Biselli, Maurizio</creatorcontrib><creatorcontrib>Caraceni, Paolo</creatorcontrib><creatorcontrib>Cucchetti, Alessandro</creatorcontrib><creatorcontrib>Domenicali, Marco</creatorcontrib><creatorcontrib>Gramenzi, Annagiulia</creatorcontrib><creatorcontrib>Magalotti, Donatella</creatorcontrib><creatorcontrib>Pecorelli, Anna</creatorcontrib><creatorcontrib>Serra, Carla</creatorcontrib><creatorcontrib>Venerandi, Laura</creatorcontrib><creatorcontrib>Gazzola, Alessia</creatorcontrib><creatorcontrib>Murer, Francesca</creatorcontrib><creatorcontrib>Pozzan, Caterina</creatorcontrib><creatorcontrib>Vanin, Veronica</creatorcontrib><creatorcontrib>Poggio, Paolo Del</creatorcontrib><creatorcontrib>Olmi, Stefano</creatorcontrib><creatorcontrib>Balsamo, Claudia</creatorcontrib><creatorcontrib>Vavassori, Elena</creatorcontrib><creatorcontrib>Benvegnù, Luisa</creatorcontrib><creatorcontrib>Capelli, Alberta</creatorcontrib><creatorcontrib>Golfieri, Rita</creatorcontrib><creatorcontrib>Mosconi, Cristina</creatorcontrib><creatorcontrib>Renzulli, Matteo</creatorcontrib><creatorcontrib>Roselli, Paola</creatorcontrib><creatorcontrib>Isola, Serena</creatorcontrib><creatorcontrib>Ialungo, Anna Maria</creatorcontrib><creatorcontrib>Rastrelli, Elena</creatorcontrib><creatorcontrib>Moscatelli, Alessandro</creatorcontrib><creatorcontrib>Pelagatta, Gaia</creatorcontrib><creatorcontrib>Picciotto, Antonino</creatorcontrib><creatorcontrib>Savarino, Vincenzo</creatorcontrib><creatorcontrib>Barcellona, Maria Rosa</creatorcontrib><creatorcontrib>Cammà, Calogero</creatorcontrib><creatorcontrib>Cabibbo, Giuseppe</creatorcontrib><creatorcontrib>Costantino, Andrea</creatorcontrib><creatorcontrib>Virdone, Roberto</creatorcontrib><creatorcontrib>Mega, Andrea</creatorcontrib><creatorcontrib>Rinninella, Emanuele</creatorcontrib><creatorcontrib>Mismas, Valeria</creatorcontrib><creatorcontrib>Dall'Aglio, Anna Chiara</creatorcontrib><creatorcontrib>Feletti, Valentina</creatorcontrib><creatorcontrib>Lanzi, Arianna</creatorcontrib><creatorcontrib>Cappa, Federica Mirici</creatorcontrib><creatorcontrib>Neri, Elga</creatorcontrib><creatorcontrib>Stefanini, Giuseppe Francesco</creatorcontrib><creatorcontrib>Tamberi, Stefano</creatorcontrib><creatorcontrib>Biasini, Elisabetta</creatorcontrib><creatorcontrib>Porro, Emanuela</creatorcontrib><creatorcontrib>Guarino, Maria</creatorcontrib><creatorcontrib>Baroni, Gianluca Svegliati</creatorcontrib><creatorcontrib>Schiadà, Laura</creatorcontrib><creatorcontrib>Chiaramonte, Maria</creatorcontrib><creatorcontrib>Marchetti, Fabiana</creatorcontrib><creatorcontrib>Valerio, Matteo</creatorcontrib><creatorcontrib>Italian Liver Cancer ITA LI CA Group</creatorcontrib><creatorcontrib>Italian Liver Cancer (ITA.LI.CA) Group</creatorcontrib><creatorcontrib>the Italian Liver Cancer (ITA.LI.CA) Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bucci, L.</au><au>Garuti, F.</au><au>Camelli, V.</au><au>Lenzi, B.</au><au>Farinati, F.</au><au>Giannini, E. G.</au><au>Ciccarese, F.</au><au>Piscaglia, F.</au><au>Rapaccini, G. L.</au><au>Di Marco, M.</au><au>Caturelli, E.</au><au>Zoli, M.</au><au>Borzio, F.</au><au>Sacco, R.</au><au>Maida, M.</au><au>Felder, M.</au><au>Morisco, F.</au><au>Gasbarrini, A.</au><au>Gemini, S.</au><au>Foschi, F. G.</au><au>Missale, G.</au><au>Masotto, A.</au><au>Affronti, A.</au><au>Bernardi, M.</au><au>Trevisani, F.</au><au>Bolondi, Luigi</au><au>Biselli, Maurizio</au><au>Caraceni, Paolo</au><au>Cucchetti, Alessandro</au><au>Domenicali, Marco</au><au>Gramenzi, Annagiulia</au><au>Magalotti, Donatella</au><au>Pecorelli, Anna</au><au>Serra, Carla</au><au>Venerandi, Laura</au><au>Gazzola, Alessia</au><au>Murer, Francesca</au><au>Pozzan, Caterina</au><au>Vanin, Veronica</au><au>Poggio, Paolo Del</au><au>Olmi, Stefano</au><au>Balsamo, Claudia</au><au>Vavassori, Elena</au><au>Benvegnù, Luisa</au><au>Capelli, Alberta</au><au>Golfieri, Rita</au><au>Mosconi, Cristina</au><au>Renzulli, Matteo</au><au>Roselli, Paola</au><au>Isola, Serena</au><au>Ialungo, Anna Maria</au><au>Rastrelli, Elena</au><au>Moscatelli, Alessandro</au><au>Pelagatta, Gaia</au><au>Picciotto, Antonino</au><au>Savarino, Vincenzo</au><au>Barcellona, Maria Rosa</au><au>Cammà, Calogero</au><au>Cabibbo, Giuseppe</au><au>Costantino, Andrea</au><au>Virdone, Roberto</au><au>Mega, Andrea</au><au>Rinninella, Emanuele</au><au>Mismas, Valeria</au><au>Dall'Aglio, Anna Chiara</au><au>Feletti, Valentina</au><au>Lanzi, Arianna</au><au>Cappa, Federica Mirici</au><au>Neri, Elga</au><au>Stefanini, Giuseppe Francesco</au><au>Tamberi, Stefano</au><au>Biasini, Elisabetta</au><au>Porro, Emanuela</au><au>Guarino, Maria</au><au>Baroni, Gianluca Svegliati</au><au>Schiadà, Laura</au><au>Chiaramonte, Maria</au><au>Marchetti, Fabiana</au><au>Valerio, Matteo</au><aucorp>Italian Liver Cancer ITA LI CA Group</aucorp><aucorp>Italian Liver Cancer (ITA.LI.CA) Group</aucorp><aucorp>the Italian Liver Cancer (ITA.LI.CA) Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison between alcohol‐ and hepatitis C virus‐related hepatocellular carcinoma: clinical presentation, treatment and outcome</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2016-02</date><risdate>2016</risdate><volume>43</volume><issue>3</issue><spage>385</spage><epage>399</epage><pages>385-399</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
Hepatitis C virus (HCV) and alcohol abuse are the main risk factors for hepatocellular carcinoma (HCC) in Western countries.
Aim
To investigate the role of alcoholic aetiology on clinical presentation, treatment and outcome of HCC as well as on each Barcelona Clinic Liver Cancer (BCLC) stage, as compared to HCV‐related HCCs.
Methods
A total of 1642 HCV and 573 alcoholic patients from the Italian Liver Cancer (ITA.LI.CA) database, diagnosed with HCC between January 2000 and December 2012 were compared for age, gender, type of diagnosis, tumour burden, portal vein thrombosis (PVT), oesophageal varices, liver function tests, alpha‐fetoprotein, BCLC, treatment and survival. Aetiology was tested as predictor of survival in multivariate Cox regression models and according to HCC stages.
Results
Cirrhosis was present in 96% of cases in both groups. Alcoholic patients were younger, more likely male, with HCC diagnosed outside surveillance, in intermediate/terminal BCLC stage and had worse liver function. After adjustment for the lead‐time, median (95% CI) overall survival (OS) was 27.4 months (21.5–33.2) in alcoholic and 33.6 months (30.7–36.5) in HCV patients (P = 0.021). The prognostic role of aetiology disappeared when survival was assessed in each BCLC stage and in the Cox regression multivariate models.
Conclusions
Alcoholic aetiology affects survival of HCC patients through its negative effects on secondary prevention and cancer presentation but not through a greater cancer aggressiveness or worse treatment result. In fact, survival adjusted for confounding factors was similar in alcoholic and HCV patients.</abstract><cop>England</cop><pmid>26662476</pmid><doi>10.1111/apt.13485</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary pharmacology & therapeutics, 2016-02, Vol.43 (3), p.385-399 |
| issn | 0269-2813 1365-2036 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1760860860 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | Age Factors Aged Aged, 80 and over alpha-Fetoproteins - metabolism Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - mortality Esophageal and Gastric Varices - epidemiology Female Hepatitis C - complications Hepatitis C - epidemiology Hepatitis C - physiopathology Hepatitis, Alcoholic - complications Hepatitis, Alcoholic - epidemiology Hepatitis, Alcoholic - physiopathology Humans Liver Function Tests Liver Neoplasms - etiology Liver Neoplasms - mortality Male Middle Aged Neoplasm Staging Prognosis Proportional Hazards Models Retrospective Studies Risk Factors Sex Factors Treatment Outcome Venous Thrombosis - epidemiology |
| title | Comparison between alcohol‐ and hepatitis C virus‐related hepatocellular carcinoma: clinical presentation, treatment and outcome |
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