A histopathological study of melanocytic and pigmented skin lesions in patients with albinism
Background Oculocutaneous albinism (OCA) is a group of genetic disorders characterized by diminished pigmentation of the skin, hair and eyes. Individuals with OCA are at increased risk to develop sun‐induced skin malignancies. The incidence of malignant melanoma in OCA individuals is, however, very...
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| Veröffentlicht in: | Journal of cutaneous pathology 2015-11, Vol.42 (11), p.840-846 |
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| container_title | Journal of cutaneous pathology |
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| creator | van der Westhuizen, Gerhard Beukes, Catherine A. Green, Brent Sinclair, Werner Goedhals, Jacqueline |
| description | Background
Oculocutaneous albinism (OCA) is a group of genetic disorders characterized by diminished pigmentation of the skin, hair and eyes. Individuals with OCA are at increased risk to develop sun‐induced skin malignancies. The incidence of malignant melanoma in OCA individuals is, however, very low. The aim of this study was to document pigmented and melanocytic skin lesions occurring in patients with OCA.
Methods
A prospective study was performed. Sixteen patients with OCA presenting at the Oncology and Dermatology Departments at Universitas Academic Hospital Annex in Bloemfontein, South Africa, were included. Selected clinically pigmented and/or melanocytic lesions were biopsied and studied by light microscopy.
Results
Twenty‐four punch biopsies were taken. Ten dendritic freckles and 10 melanocytic nevi were confirmed histologically. The nevi, which occurred in eight patients, were found on sun‐protected skin. All the freckles occurred on sun‐exposed skin. Twelve patients had current or previous skin malignancies. No melanomas were present in the study population. Other skin lesions ranged from solar keratoses to squamous cell carcinomas.
Conclusion
The majority of pigmented lesions were dendritic freckles that occurred on sun‐exposed skin. None of the patients had a current or previous diagnosis of malignant melanoma. |
| doi_str_mv | 10.1111/cup.12588 |
| format | Article |
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Oculocutaneous albinism (OCA) is a group of genetic disorders characterized by diminished pigmentation of the skin, hair and eyes. Individuals with OCA are at increased risk to develop sun‐induced skin malignancies. The incidence of malignant melanoma in OCA individuals is, however, very low. The aim of this study was to document pigmented and melanocytic skin lesions occurring in patients with OCA.
Methods
A prospective study was performed. Sixteen patients with OCA presenting at the Oncology and Dermatology Departments at Universitas Academic Hospital Annex in Bloemfontein, South Africa, were included. Selected clinically pigmented and/or melanocytic lesions were biopsied and studied by light microscopy.
Results
Twenty‐four punch biopsies were taken. Ten dendritic freckles and 10 melanocytic nevi were confirmed histologically. The nevi, which occurred in eight patients, were found on sun‐protected skin. All the freckles occurred on sun‐exposed skin. Twelve patients had current or previous skin malignancies. No melanomas were present in the study population. Other skin lesions ranged from solar keratoses to squamous cell carcinomas.
Conclusion
The majority of pigmented lesions were dendritic freckles that occurred on sun‐exposed skin. None of the patients had a current or previous diagnosis of malignant melanoma.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/cup.12588</identifier><identifier>PMID: 26268889</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; albinism ; Albinism, Oculocutaneous - metabolism ; Albinism, Oculocutaneous - pathology ; Female ; freckle ; Humans ; Keratosis, Seborrheic - metabolism ; Keratosis, Seborrheic - pathology ; Male ; malignant melanoma ; Melanoma - metabolism ; Melanoma - pathology ; Melanoma, Cutaneous Malignant ; Middle Aged ; Monophenol Monooxygenase - metabolism ; nevus ; Nevus, Pigmented - metabolism ; Nevus, Pigmented - pathology ; Prospective Studies ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; solar keratosis</subject><ispartof>Journal of cutaneous pathology, 2015-11, Vol.42 (11), p.840-846</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4338-f07d4b92532bfb6ff3bb9a36b28e8a28e5e231b7e00437ed693025476bbbc95d3</citedby><cites>FETCH-LOGICAL-c4338-f07d4b92532bfb6ff3bb9a36b28e8a28e5e231b7e00437ed693025476bbbc95d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcup.12588$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcup.12588$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26268889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Westhuizen, Gerhard</creatorcontrib><creatorcontrib>Beukes, Catherine A.</creatorcontrib><creatorcontrib>Green, Brent</creatorcontrib><creatorcontrib>Sinclair, Werner</creatorcontrib><creatorcontrib>Goedhals, Jacqueline</creatorcontrib><title>A histopathological study of melanocytic and pigmented skin lesions in patients with albinism</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>Background
Oculocutaneous albinism (OCA) is a group of genetic disorders characterized by diminished pigmentation of the skin, hair and eyes. Individuals with OCA are at increased risk to develop sun‐induced skin malignancies. The incidence of malignant melanoma in OCA individuals is, however, very low. The aim of this study was to document pigmented and melanocytic skin lesions occurring in patients with OCA.
Methods
A prospective study was performed. Sixteen patients with OCA presenting at the Oncology and Dermatology Departments at Universitas Academic Hospital Annex in Bloemfontein, South Africa, were included. Selected clinically pigmented and/or melanocytic lesions were biopsied and studied by light microscopy.
Results
Twenty‐four punch biopsies were taken. Ten dendritic freckles and 10 melanocytic nevi were confirmed histologically. The nevi, which occurred in eight patients, were found on sun‐protected skin. All the freckles occurred on sun‐exposed skin. Twelve patients had current or previous skin malignancies. No melanomas were present in the study population. Other skin lesions ranged from solar keratoses to squamous cell carcinomas.
Conclusion
The majority of pigmented lesions were dendritic freckles that occurred on sun‐exposed skin. None of the patients had a current or previous diagnosis of malignant melanoma.</description><subject>Adult</subject><subject>Aged</subject><subject>albinism</subject><subject>Albinism, Oculocutaneous - metabolism</subject><subject>Albinism, Oculocutaneous - pathology</subject><subject>Female</subject><subject>freckle</subject><subject>Humans</subject><subject>Keratosis, Seborrheic - metabolism</subject><subject>Keratosis, Seborrheic - pathology</subject><subject>Male</subject><subject>malignant melanoma</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - pathology</subject><subject>Melanoma, Cutaneous Malignant</subject><subject>Middle Aged</subject><subject>Monophenol Monooxygenase - metabolism</subject><subject>nevus</subject><subject>Nevus, Pigmented - metabolism</subject><subject>Nevus, Pigmented - pathology</subject><subject>Prospective Studies</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>solar keratosis</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMlOwzAURS0EgjIs-AHkJSwCHuohS6iYRAUsaJGQkGUnTmuaxCFOVPr3GArs8OLZks-9ejoAHGJ0iuM5y_rmFBMm5QYYYI5QghhHm2CAKKIJT6XYAbshvCGEueRsG-wQTriUMh2A13M4d6Hzje7mvvQzl-kShq7PV9AXsLKlrn226lwGdZ3Dxs0qW3c2h2Hhalja4HwdYHzGvIs_AS5dN4e6NK52odoHW4Uugz34uffA5OryaXSTjB-ub0fn4yQbUiqTAol8aFLCKDGF4UVBjUk15YZIK3UczBKKjbAIDamwOU8pImwouDEmS1lO98Dxurdp_XtvQ6cqFzJbxu2t74PCgiPJuMAsoidrNGt9CK0tVNO6SrcrhZH6sqmiTfVtM7JHP7W9qWz-R_7qi8DZGli60q7-b1KjyeNvZbJOROn24y-h24Xiggqmnu-v1ZRM75i8EOqFfgKBoo74</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>van der Westhuizen, Gerhard</creator><creator>Beukes, Catherine A.</creator><creator>Green, Brent</creator><creator>Sinclair, Werner</creator><creator>Goedhals, Jacqueline</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>A histopathological study of melanocytic and pigmented skin lesions in patients with albinism</title><author>van der Westhuizen, Gerhard ; Beukes, Catherine A. ; Green, Brent ; Sinclair, Werner ; Goedhals, Jacqueline</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4338-f07d4b92532bfb6ff3bb9a36b28e8a28e5e231b7e00437ed693025476bbbc95d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>albinism</topic><topic>Albinism, Oculocutaneous - metabolism</topic><topic>Albinism, Oculocutaneous - pathology</topic><topic>Female</topic><topic>freckle</topic><topic>Humans</topic><topic>Keratosis, Seborrheic - metabolism</topic><topic>Keratosis, Seborrheic - pathology</topic><topic>Male</topic><topic>malignant melanoma</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - pathology</topic><topic>Melanoma, Cutaneous Malignant</topic><topic>Middle Aged</topic><topic>Monophenol Monooxygenase - metabolism</topic><topic>nevus</topic><topic>Nevus, Pigmented - metabolism</topic><topic>Nevus, Pigmented - pathology</topic><topic>Prospective Studies</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><topic>solar keratosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Westhuizen, Gerhard</creatorcontrib><creatorcontrib>Beukes, Catherine A.</creatorcontrib><creatorcontrib>Green, Brent</creatorcontrib><creatorcontrib>Sinclair, Werner</creatorcontrib><creatorcontrib>Goedhals, Jacqueline</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Westhuizen, Gerhard</au><au>Beukes, Catherine A.</au><au>Green, Brent</au><au>Sinclair, Werner</au><au>Goedhals, Jacqueline</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A histopathological study of melanocytic and pigmented skin lesions in patients with albinism</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2015-11</date><risdate>2015</risdate><volume>42</volume><issue>11</issue><spage>840</spage><epage>846</epage><pages>840-846</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><abstract>Background
Oculocutaneous albinism (OCA) is a group of genetic disorders characterized by diminished pigmentation of the skin, hair and eyes. Individuals with OCA are at increased risk to develop sun‐induced skin malignancies. The incidence of malignant melanoma in OCA individuals is, however, very low. The aim of this study was to document pigmented and melanocytic skin lesions occurring in patients with OCA.
Methods
A prospective study was performed. Sixteen patients with OCA presenting at the Oncology and Dermatology Departments at Universitas Academic Hospital Annex in Bloemfontein, South Africa, were included. Selected clinically pigmented and/or melanocytic lesions were biopsied and studied by light microscopy.
Results
Twenty‐four punch biopsies were taken. Ten dendritic freckles and 10 melanocytic nevi were confirmed histologically. The nevi, which occurred in eight patients, were found on sun‐protected skin. All the freckles occurred on sun‐exposed skin. Twelve patients had current or previous skin malignancies. No melanomas were present in the study population. Other skin lesions ranged from solar keratoses to squamous cell carcinomas.
Conclusion
The majority of pigmented lesions were dendritic freckles that occurred on sun‐exposed skin. None of the patients had a current or previous diagnosis of malignant melanoma.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>26268889</pmid><doi>10.1111/cup.12588</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of cutaneous pathology, 2015-11, Vol.42 (11), p.840-846 |
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| subjects | Adult Aged albinism Albinism, Oculocutaneous - metabolism Albinism, Oculocutaneous - pathology Female freckle Humans Keratosis, Seborrheic - metabolism Keratosis, Seborrheic - pathology Male malignant melanoma Melanoma - metabolism Melanoma - pathology Melanoma, Cutaneous Malignant Middle Aged Monophenol Monooxygenase - metabolism nevus Nevus, Pigmented - metabolism Nevus, Pigmented - pathology Prospective Studies Skin Neoplasms - metabolism Skin Neoplasms - pathology solar keratosis |
| title | A histopathological study of melanocytic and pigmented skin lesions in patients with albinism |
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