Internalization of Tissue Factor-Rich Microvesicles by Platelets Occurs Independently of GPIIb-IIIa, and Involves CD36 Receptor, Serotonin Transporter and Cytoskeletal Assembly

ABSTRACT Platelets are important in hemostasis, but also detect particles and pathogens in the circulation. Phagocytic and endocytic activities of platelets are widely recognized; however, receptors and mechanisms involved remain poorly understood. We previously demonstrated that platelets internali...

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Veröffentlicht in:	Journal of cellular biochemistry 2016-02, Vol.117 (2), p.448-457
Hauptverfasser:	Lopez-Vilchez, Irene, Diaz-Ricart, Maribel, Galan, Ana M., Roque, Merce, Caballo, Carolina, Molina, Patricia, White, James G., Escolar, Gines
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - physiology CD36 Antigens - metabolism CELL-DERIVED MICROPARTICLES Cell-Derived Microparticles - metabolism Cells, Cultured CYTOSKELETON Cytoskeleton - metabolism Enzyme Activation Humans Integrin beta3 - metabolism INTERNALIZATION Peptide Fragments - metabolism Phosphatidylinositol 3-Kinases - metabolism Platelet Aggregation Platelet Glycoprotein GPIb-IX Complex - metabolism PLATELETS Protein Transport rhoA GTP-Binding Protein - metabolism Serotonin Plasma Membrane Transport Proteins - metabolism Signal Transduction Thromboplastin - metabolism TISSUE FACTOR
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