Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

The authors analyze the extent of intratumor heterogeneity across 12 tumor types to reveal that increased heterogeneity is a general phenomenon and has a biphasic contribution to tumor progression. Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We used the b...

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Veröffentlicht in:	Nature medicine 2016-01, Vol.22 (1), p.105-113
Hauptverfasser:	Andor, Noemi, Graham, Trevor A, Jansen, Marnix, Xia, Li C, Aktipis, C Athena, Petritsch, Claudia, Ji, Hanlee P, Maley, Carlo C
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 631/114/2401 631/181 631/67/69 analysis Bioinformatics Biomedicine Cancer Cancer Research Cell Nucleus Shape - genetics Clone Cells Cloning Computational Biology Correlation coefficient DNA Copy Number Variations - genetics Gene Frequency Genetic aspects Genetic Heterogeneity Genetics Genomic Instability - genetics Health risks Heterogeneity Humans Infectious Diseases Metabolic Diseases Molecular Medicine Mortality risk Mutation Mutation - genetics Neoplasms - genetics Neoplasms - mortality Neurosciences Proportional Hazards Models Risk factors Subpopulations Tumorigenesis Tumors
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