Effects of ritanserin on ethanol withdrawal–induced anxiety in rats

This study investigated the ability of ritanserin, a 5-HT2 antagonist, to modify ethanol withdrawal (EW) symptoms in two animal models of anxiety: the elevated plus-maze (EPM) and the pentylenetetrazol (PTZ) discrimination assay. Long–Evans hooded rats were given a nutritionally balanced liquid diet...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 2000-05, Vol.21 (1), p.11-17
Hauptverfasser:	Gatch, Michael B, Wallis, Cleatus J, Lal, Harbans
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Anti-Anxiety Agents - therapeutic use Anxiety Anxiety - chemically induced Anxiety - drug therapy Biological and medical sciences Central Nervous System Depressants - adverse effects Discrimination Learning - drug effects Drug addictions Drug discrimination Drug withdrawal Elevated plus-maze Ethanol - adverse effects Ethanol withdrawal GABA A receptor Male Medical sciences Motor activity Motor Activity - drug effects pentylenetetrazol Rats Rats, Long-Evans ritanserin Ritanserin - pharmacology Ritanserin - therapeutic use Serotonin Substance Withdrawal Syndrome - drug therapy Toxicology
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