Chronic Morphine Treatment and Withdrawal Increase Extracellular Levels of Norepinephrine in the Rat Bed Nucleus of the Stria Terminalis
Extracellular levels of norepinephrine (NE) and glutamate (Glu) in the ventral bed nucleus of the stria terminalis (vBNST) of saline‐ and chronic morphine‐treated rats, with or without withdrawal, were studied by means of the in vivo microdialysis technique in anesthetized rats. In addition, the tis...
Gespeichert in:
| Veröffentlicht in: | Journal of neurochemistry 2000-08, Vol.75 (2), p.741-748 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 748 |
|---|---|
| container_issue | 2 |
| container_start_page | 741 |
| container_title | Journal of neurochemistry |
| container_volume | 75 |
| creator | Fuentealba, José Antonio Forray, María Inés Gysling, Katia |
| description | Extracellular levels of norepinephrine (NE) and glutamate (Glu) in the ventral bed nucleus of the stria terminalis (vBNST) of saline‐ and chronic morphine‐treated rats, with or without withdrawal, were studied by means of the in vivo microdialysis technique in anesthetized rats. In addition, the tissue concentration of NE was studied at different rostrocaudal levels of the vBNST. Chronic morphine treatment significantly increased extracellular levels of NE, but not Glu, in vBNST. At 48 h after naloxone‐induced morphine withdrawal there was a further significant increase in the extracellular levels of NE, but not Glu, in vBNST. The presence of UK 14304, an α2‐adrenergic agonist, induced a significant decrease in NE extracellular levels in all experimental groups. In contrast, UK 14304 induced a significant decrease in Glu extracellular levels only in saline‐treated rats. The results also show that the vBNST presents a rostrocaudal gradient of NE and contains 9.4% of total brain NE. The increase in NE extracellular levels in vBNST induced by chronic morphine treatment and the further increase in NE levels 48 h after naloxone‐induced morphine withdrawal suggest that NE in vBNST may be involved in the pharmacological effects of chronic morphine and withdrawal. |
| doi_str_mv | 10.1046/j.1471-4159.2000.0750741.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17605836</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17605836</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5521-3b5e56cb1844cb4fd3edc43456f8de34f78b7e5540ce9aaad3147c4178d9eda13</originalsourceid><addsrcrecordid>eNqVkcuO1DAQRS0EYpqBX0AWQuwS7MTOgx3TGmBQ00jQiKVVsSuKW85j7ITp-QM-m4SOgC0ry65Tt8r3EvKCs5gzkb0-xlzkPBJclnHCGItZLlkueHx6QDZ_Sg_JhrEkiVImkgvyJIQjYzwTGX9MLjgryrKUbEN-bhvfd1bTT70fGtshPXiEscVupNAZ-t2OjfFwB47edHouBaTXp9GDRucmB57u8Ae6QPua7nuPwywxNH4Rsh0dG6RfYKRXaOh-0g6n3-Dy_HX0FugBfWs7cDY8JY9qcAGfrecl-fbu-rD9EO0-v7_Zvt1FWsqER2klUWa64oUQuhK1SdFokQqZ1YXBVNR5UeUopWAaSwAw6WyIFjwvTIkGeHpJXp11B9_fThhG1dqwfAY67KegeJ4xWaTZDL45g9r3IXis1eBtC_5ecaaWHNRRLWarxWy15KDWHNRpbn6-TpmqFs0_rWfjZ-DlCkDQ4GoPnbbhLyd5ItiyxNUZu7MO7_9jA_Vxv10v6S8m7Kas</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17605836</pqid></control><display><type>article</type><title>Chronic Morphine Treatment and Withdrawal Increase Extracellular Levels of Norepinephrine in the Rat Bed Nucleus of the Stria Terminalis</title><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>Access via Wiley Online Library</source><source>IngentaConnect Free/Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Fuentealba, José Antonio ; Forray, María Inés ; Gysling, Katia</creator><creatorcontrib>Fuentealba, José Antonio ; Forray, María Inés ; Gysling, Katia</creatorcontrib><description>Extracellular levels of norepinephrine (NE) and glutamate (Glu) in the ventral bed nucleus of the stria terminalis (vBNST) of saline‐ and chronic morphine‐treated rats, with or without withdrawal, were studied by means of the in vivo microdialysis technique in anesthetized rats. In addition, the tissue concentration of NE was studied at different rostrocaudal levels of the vBNST. Chronic morphine treatment significantly increased extracellular levels of NE, but not Glu, in vBNST. At 48 h after naloxone‐induced morphine withdrawal there was a further significant increase in the extracellular levels of NE, but not Glu, in vBNST. The presence of UK 14304, an α2‐adrenergic agonist, induced a significant decrease in NE extracellular levels in all experimental groups. In contrast, UK 14304 induced a significant decrease in Glu extracellular levels only in saline‐treated rats. The results also show that the vBNST presents a rostrocaudal gradient of NE and contains 9.4% of total brain NE. The increase in NE extracellular levels in vBNST induced by chronic morphine treatment and the further increase in NE levels 48 h after naloxone‐induced morphine withdrawal suggest that NE in vBNST may be involved in the pharmacological effects of chronic morphine and withdrawal.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1046/j.1471-4159.2000.0750741.x</identifier><identifier>PMID: 10899950</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford UK: Blackwell Science Ltd</publisher><subject>Adrenergic alpha-Agonists - pharmacology ; Animals ; bed nucleus ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Brimonidine Tartrate ; Extracellular Space - drug effects ; Extracellular Space - metabolism ; Glutamic Acid - metabolism ; In Vitro Techniques ; Male ; Medical sciences ; Microdialysis ; Morphine ; Morphine - pharmacology ; Morphine Dependence - metabolism ; Naloxone ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Norepinephrine ; Norepinephrine - metabolism ; Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems ; Pharmacology. Drug treatments ; Quinoxalines - pharmacology ; Rats ; Rats, Sprague-Dawley ; Septal Nuclei - drug effects ; Septal Nuclei - metabolism ; Substance Withdrawal Syndrome - metabolism ; Ventral bed nucleus of the stria terminalis ; Withdrawal</subject><ispartof>Journal of neurochemistry, 2000-08, Vol.75 (2), p.741-748</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5521-3b5e56cb1844cb4fd3edc43456f8de34f78b7e5540ce9aaad3147c4178d9eda13</citedby><cites>FETCH-LOGICAL-c5521-3b5e56cb1844cb4fd3edc43456f8de34f78b7e5540ce9aaad3147c4178d9eda13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1471-4159.2000.0750741.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1471-4159.2000.0750741.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1512406$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10899950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuentealba, José Antonio</creatorcontrib><creatorcontrib>Forray, María Inés</creatorcontrib><creatorcontrib>Gysling, Katia</creatorcontrib><title>Chronic Morphine Treatment and Withdrawal Increase Extracellular Levels of Norepinephrine in the Rat Bed Nucleus of the Stria Terminalis</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>Extracellular levels of norepinephrine (NE) and glutamate (Glu) in the ventral bed nucleus of the stria terminalis (vBNST) of saline‐ and chronic morphine‐treated rats, with or without withdrawal, were studied by means of the in vivo microdialysis technique in anesthetized rats. In addition, the tissue concentration of NE was studied at different rostrocaudal levels of the vBNST. Chronic morphine treatment significantly increased extracellular levels of NE, but not Glu, in vBNST. At 48 h after naloxone‐induced morphine withdrawal there was a further significant increase in the extracellular levels of NE, but not Glu, in vBNST. The presence of UK 14304, an α2‐adrenergic agonist, induced a significant decrease in NE extracellular levels in all experimental groups. In contrast, UK 14304 induced a significant decrease in Glu extracellular levels only in saline‐treated rats. The results also show that the vBNST presents a rostrocaudal gradient of NE and contains 9.4% of total brain NE. The increase in NE extracellular levels in vBNST induced by chronic morphine treatment and the further increase in NE levels 48 h after naloxone‐induced morphine withdrawal suggest that NE in vBNST may be involved in the pharmacological effects of chronic morphine and withdrawal.</description><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Animals</subject><subject>bed nucleus</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brimonidine Tartrate</subject><subject>Extracellular Space - drug effects</subject><subject>Extracellular Space - metabolism</subject><subject>Glutamic Acid - metabolism</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microdialysis</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Morphine Dependence - metabolism</subject><subject>Naloxone</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinoxalines - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Septal Nuclei - drug effects</subject><subject>Septal Nuclei - metabolism</subject><subject>Substance Withdrawal Syndrome - metabolism</subject><subject>Ventral bed nucleus of the stria terminalis</subject><subject>Withdrawal</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcuO1DAQRS0EYpqBX0AWQuwS7MTOgx3TGmBQ00jQiKVVsSuKW85j7ITp-QM-m4SOgC0ry65Tt8r3EvKCs5gzkb0-xlzkPBJclnHCGItZLlkueHx6QDZ_Sg_JhrEkiVImkgvyJIQjYzwTGX9MLjgryrKUbEN-bhvfd1bTT70fGtshPXiEscVupNAZ-t2OjfFwB47edHouBaTXp9GDRucmB57u8Ae6QPua7nuPwywxNH4Rsh0dG6RfYKRXaOh-0g6n3-Dy_HX0FugBfWs7cDY8JY9qcAGfrecl-fbu-rD9EO0-v7_Zvt1FWsqER2klUWa64oUQuhK1SdFokQqZ1YXBVNR5UeUopWAaSwAw6WyIFjwvTIkGeHpJXp11B9_fThhG1dqwfAY67KegeJ4xWaTZDL45g9r3IXis1eBtC_5ecaaWHNRRLWarxWy15KDWHNRpbn6-TpmqFs0_rWfjZ-DlCkDQ4GoPnbbhLyd5ItiyxNUZu7MO7_9jA_Vxv10v6S8m7Kas</recordid><startdate>200008</startdate><enddate>200008</enddate><creator>Fuentealba, José Antonio</creator><creator>Forray, María Inés</creator><creator>Gysling, Katia</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>200008</creationdate><title>Chronic Morphine Treatment and Withdrawal Increase Extracellular Levels of Norepinephrine in the Rat Bed Nucleus of the Stria Terminalis</title><author>Fuentealba, José Antonio ; Forray, María Inés ; Gysling, Katia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5521-3b5e56cb1844cb4fd3edc43456f8de34f78b7e5540ce9aaad3147c4178d9eda13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adrenergic alpha-Agonists - pharmacology</topic><topic>Animals</topic><topic>bed nucleus</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brimonidine Tartrate</topic><topic>Extracellular Space - drug effects</topic><topic>Extracellular Space - metabolism</topic><topic>Glutamic Acid - metabolism</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microdialysis</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Morphine Dependence - metabolism</topic><topic>Naloxone</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinoxalines - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Septal Nuclei - drug effects</topic><topic>Septal Nuclei - metabolism</topic><topic>Substance Withdrawal Syndrome - metabolism</topic><topic>Ventral bed nucleus of the stria terminalis</topic><topic>Withdrawal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuentealba, José Antonio</creatorcontrib><creatorcontrib>Forray, María Inés</creatorcontrib><creatorcontrib>Gysling, Katia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuentealba, José Antonio</au><au>Forray, María Inés</au><au>Gysling, Katia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic Morphine Treatment and Withdrawal Increase Extracellular Levels of Norepinephrine in the Rat Bed Nucleus of the Stria Terminalis</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2000-08</date><risdate>2000</risdate><volume>75</volume><issue>2</issue><spage>741</spage><epage>748</epage><pages>741-748</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>Extracellular levels of norepinephrine (NE) and glutamate (Glu) in the ventral bed nucleus of the stria terminalis (vBNST) of saline‐ and chronic morphine‐treated rats, with or without withdrawal, were studied by means of the in vivo microdialysis technique in anesthetized rats. In addition, the tissue concentration of NE was studied at different rostrocaudal levels of the vBNST. Chronic morphine treatment significantly increased extracellular levels of NE, but not Glu, in vBNST. At 48 h after naloxone‐induced morphine withdrawal there was a further significant increase in the extracellular levels of NE, but not Glu, in vBNST. The presence of UK 14304, an α2‐adrenergic agonist, induced a significant decrease in NE extracellular levels in all experimental groups. In contrast, UK 14304 induced a significant decrease in Glu extracellular levels only in saline‐treated rats. The results also show that the vBNST presents a rostrocaudal gradient of NE and contains 9.4% of total brain NE. The increase in NE extracellular levels in vBNST induced by chronic morphine treatment and the further increase in NE levels 48 h after naloxone‐induced morphine withdrawal suggest that NE in vBNST may be involved in the pharmacological effects of chronic morphine and withdrawal.</abstract><cop>Oxford UK</cop><pub>Blackwell Science Ltd</pub><pmid>10899950</pmid><doi>10.1046/j.1471-4159.2000.0750741.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3042 |
| ispartof | Journal of neurochemistry, 2000-08, Vol.75 (2), p.741-748 |
| issn | 0022-3042 1471-4159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17605836 |
| source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Adrenergic alpha-Agonists - pharmacology Animals bed nucleus Biological and medical sciences Brain - drug effects Brain - metabolism Brimonidine Tartrate Extracellular Space - drug effects Extracellular Space - metabolism Glutamic Acid - metabolism In Vitro Techniques Male Medical sciences Microdialysis Morphine Morphine - pharmacology Morphine Dependence - metabolism Naloxone Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Norepinephrine Norepinephrine - metabolism Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Septal Nuclei - drug effects Septal Nuclei - metabolism Substance Withdrawal Syndrome - metabolism Ventral bed nucleus of the stria terminalis Withdrawal |
| title | Chronic Morphine Treatment and Withdrawal Increase Extracellular Levels of Norepinephrine in the Rat Bed Nucleus of the Stria Terminalis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A36%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20Morphine%20Treatment%20and%20Withdrawal%20Increase%20Extracellular%20Levels%20of%20Norepinephrine%20in%20the%20Rat%20Bed%20Nucleus%20of%20the%20Stria%20Terminalis&rft.jtitle=Journal%20of%20neurochemistry&rft.au=Fuentealba,%20Jos%C3%A9%20Antonio&rft.date=2000-08&rft.volume=75&rft.issue=2&rft.spage=741&rft.epage=748&rft.pages=741-748&rft.issn=0022-3042&rft.eissn=1471-4159&rft.coden=JONRA9&rft_id=info:doi/10.1046/j.1471-4159.2000.0750741.x&rft_dat=%3Cproquest_cross%3E17605836%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17605836&rft_id=info:pmid/10899950&rfr_iscdi=true |