pH-sensitivity and pH-dependent interior structural change of self-assembled hydrogel nanoparticles of pullulan acetate/oligo-sulfonamide conjugate

pH-sensitivity and pH-dependent interior structural change of self-assembled hydrogel nanoparticles of pullulan acetate/oligo-sulfonamide conjugate

pH-sensitive hydrogel nanoparticles that respond to the local acidic pH found in various diseased states such as tumors, ischemia and inflammation were prepared from pullulan acetate/oligo-sulfadimethoxine (PA/OSDM) conjugates. PA/OSDM nanoparticles prepared by dialysis at pH 9.5 had a spherical sha...

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Veröffentlicht in:Journal of controlled release 2004-07, Vol.97 (3), p.513-525
Hauptverfasser: Na, Kun, Lee, Kwang Hee, Bae, You Han
Format: Artikel
Sprache:eng
Schlagworte:
Interior structure
Microviscosity
Oligo-sulfadimethoxine
pH-sensitive hydrogel nanoparticles
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Zusammenfassung:pH-sensitive hydrogel nanoparticles that respond to the local acidic pH found in various diseased states such as tumors, ischemia and inflammation were prepared from pullulan acetate/oligo-sulfadimethoxine (PA/OSDM) conjugates. PA/OSDM nanoparticles prepared by dialysis at pH 9.5 had a spherical shape with a size range of 50–140 nm and low critical aggregation concentration (CAC) (
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2004.04.005