Synthesis and Biological Evaluation of EC72: A New Folate-Targeted Chemotherapeutic

A novel folate conjugate of mitomycin C, herein referred to as EC72, was designed and evaluated for biological activity against FR-positive cells and tumors. EC72 was produced by coupling folic acid-γ-cysteine to 7-N-modified MMC via a disulfide bond. This water soluble conjugate was found to retain...

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Veröffentlicht in:	Bioconjugate chemistry 2005-07, Vol.16 (4), p.803-811
Hauptverfasser:	Leamon, Christopher P, Reddy, Joseph A, Vlahov, Iontcho R, Vetzel, Marilynn, Parker, Nikki, Nicoson, Jeffrey S, Xu, Le-Cun, Westrick, Elaine
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antineoplastic Agents - blood Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Biology Cell Line Cells Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Female Folic Acid - analogs & derivatives Folic Acid - blood Folic Acid - chemical synthesis Folic Acid - chemistry Folic Acid - pharmacology Humans Kinetics Magnetic Resonance Spectroscopy Mice Mice, Inbred BALB C Tumors
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