Developmental stage-dependent protective effect of NGF against lead cholinotoxicity in the rat septum
The ability of nerve growth factor (NGF) to ameliorate developmental cholinotoxicity of inorganic lead (Pb) for the septal neurons was investigated by making intracerebroventricular injections of single doses of 30 μg 2.5S NGF into maternally lead-exposed suckling rats on postnatal days P2, P4, P11,...
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| Veröffentlicht in: | Brain research 2000-06, Vol.866 (1), p.268-273 |
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| creator | Zhou, M Tian, X Suszkiw, J.B |
| description | The ability of nerve growth factor (NGF) to ameliorate developmental cholinotoxicity of inorganic lead (Pb) for the septal neurons was investigated by making intracerebroventricular injections of single doses of 30 μg 2.5S NGF into maternally lead-exposed suckling rats on postnatal days P2, P4, P11, or P18. Administration of NGF on P4 or later induced septal choline acetyltransferase (ChAT) activity to the same relative extent in both Pb-exposed as in control rats but failed to reverse the net reductions of ChAT activity induced by Pb. In contrast, injection of NGF at P2 completely restored ChAT activity in Pb-exposed pups to control levels by preventing the loss of ChAT-immunoreactive cells in the septum. It is concluded that although NGF retains the capacity to upregulate ChAT throughout the period of Pb exposure, it protects against the Pb-induced loss of septal cholinergic neurons only when applied within the critical period of Pb-vulnerability between postnatal days 2 and 4. |
| doi_str_mv | 10.1016/S0006-8993(00)02265-4 |
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Administration of NGF on P4 or later induced septal choline acetyltransferase (ChAT) activity to the same relative extent in both Pb-exposed as in control rats but failed to reverse the net reductions of ChAT activity induced by Pb. In contrast, injection of NGF at P2 completely restored ChAT activity in Pb-exposed pups to control levels by preventing the loss of ChAT-immunoreactive cells in the septum. It is concluded that although NGF retains the capacity to upregulate ChAT throughout the period of Pb exposure, it protects against the Pb-induced loss of septal cholinergic neurons only when applied within the critical period of Pb-vulnerability between postnatal days 2 and 4.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(00)02265-4</identifier><identifier>PMID: 10825503</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Acetylcholine - metabolism ; Age Factors ; Animals ; Animals, Newborn ; Biological and medical sciences ; Choline O-Acetyltransferase - metabolism ; Cholineacetyltransferase ; Cholinergic Fibers - drug effects ; Cholinergic Fibers - metabolism ; Cholinergic Fibers - ultrastructure ; Cholinergic neurons ; Development ; Female ; Lead - toxicity ; Lead cholinotoxicity ; Lead Poisoning, Nervous System, Childhood - drug therapy ; Lead Poisoning, Nervous System, Childhood - physiopathology ; Maternal Exposure - adverse effects ; Medical sciences ; Nerve Growth Factor - metabolism ; Nerve Growth Factor - pharmacology ; Neurons - cytology ; Neurons - drug effects ; Neurons - metabolism ; Neuropharmacology ; Neuroprotective agent ; Neuroprotective Agents - metabolism ; Neuroprotective Agents - pharmacology ; NGF ; Pharmacology. Drug treatments ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Septal Nuclei - drug effects ; Septal Nuclei - growth & development ; Septal Nuclei - metabolism ; Septum</subject><ispartof>Brain research, 2000-06, Vol.866 (1), p.268-273</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c369t-a8a6763974450dde2e846d99a9ef973840c4267f6f5f63a2893876c4a10d160e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(00)02265-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1412028$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10825503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, M</creatorcontrib><creatorcontrib>Tian, X</creatorcontrib><creatorcontrib>Suszkiw, J.B</creatorcontrib><title>Developmental stage-dependent protective effect of NGF against lead cholinotoxicity in the rat septum</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The ability of nerve growth factor (NGF) to ameliorate developmental cholinotoxicity of inorganic lead (Pb) for the septal neurons was investigated by making intracerebroventricular injections of single doses of 30 μg 2.5S NGF into maternally lead-exposed suckling rats on postnatal days P2, P4, P11, or P18. Administration of NGF on P4 or later induced septal choline acetyltransferase (ChAT) activity to the same relative extent in both Pb-exposed as in control rats but failed to reverse the net reductions of ChAT activity induced by Pb. In contrast, injection of NGF at P2 completely restored ChAT activity in Pb-exposed pups to control levels by preventing the loss of ChAT-immunoreactive cells in the septum. It is concluded that although NGF retains the capacity to upregulate ChAT throughout the period of Pb exposure, it protects against the Pb-induced loss of septal cholinergic neurons only when applied within the critical period of Pb-vulnerability between postnatal days 2 and 4.</description><subject>Acetylcholine - metabolism</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Cholineacetyltransferase</subject><subject>Cholinergic Fibers - drug effects</subject><subject>Cholinergic Fibers - metabolism</subject><subject>Cholinergic Fibers - ultrastructure</subject><subject>Cholinergic neurons</subject><subject>Development</subject><subject>Female</subject><subject>Lead - toxicity</subject><subject>Lead cholinotoxicity</subject><subject>Lead Poisoning, Nervous System, Childhood - drug therapy</subject><subject>Lead Poisoning, Nervous System, Childhood - physiopathology</subject><subject>Maternal Exposure - adverse effects</subject><subject>Medical sciences</subject><subject>Nerve Growth Factor - metabolism</subject><subject>Nerve Growth Factor - pharmacology</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Neuroprotective Agents - metabolism</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>NGF</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Septal Nuclei - drug effects</subject><subject>Septal Nuclei - growth & development</subject><subject>Septal Nuclei - metabolism</subject><subject>Septum</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtrVDEUgIModlr9CUoWInVx9eRxc5NVkWqrUHShrkNMTtrIfZlkBvvvTTuDunN1HnznwUfIMwavGTD15gsAqE4bI04BXgHnqu_kA7JheuCd4hIeks0f5Igcl_KjlUIYeEyOGGje9yA2BN_hDsdlnXCubqSlumvsAq44h9aha14q-pp2SDHGltEl0k-XF9RduzSXSkd0gfqbZUzzUpdfyad6S9NM6w3S7CotuNbt9IQ8im4s-PQQT8i3i_dfzz90V58vP56_veq8UKZ2Tjs1KGEGKXsIATlqqYIxzmA0g9ASvORqiCr2UQnHtRF6UF46BoEpQHFCXu73tr9_brFUO6XicRzdjMu2WDYo4M1eA_s96PNSSsZo15wml28tA3vn1977tXfyLIC992tlm3t-OLD9PmH4Z2ovtAEvDoAr3o0xu9mn8peTjAPXDTvbY9hs7BJmW3zC2WNIuVm2YUn_-eQ3pnGXEQ</recordid><startdate>20000602</startdate><enddate>20000602</enddate><creator>Zhou, M</creator><creator>Tian, X</creator><creator>Suszkiw, J.B</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20000602</creationdate><title>Developmental stage-dependent protective effect of NGF against lead cholinotoxicity in the rat septum</title><author>Zhou, M ; Tian, X ; Suszkiw, J.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-a8a6763974450dde2e846d99a9ef973840c4267f6f5f63a2893876c4a10d160e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Acetylcholine - metabolism</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Cholineacetyltransferase</topic><topic>Cholinergic Fibers - drug effects</topic><topic>Cholinergic Fibers - metabolism</topic><topic>Cholinergic Fibers - ultrastructure</topic><topic>Cholinergic neurons</topic><topic>Development</topic><topic>Female</topic><topic>Lead - toxicity</topic><topic>Lead cholinotoxicity</topic><topic>Lead Poisoning, Nervous System, Childhood - drug therapy</topic><topic>Lead Poisoning, Nervous System, Childhood - physiopathology</topic><topic>Maternal Exposure - adverse effects</topic><topic>Medical sciences</topic><topic>Nerve Growth Factor - metabolism</topic><topic>Nerve Growth Factor - pharmacology</topic><topic>Neurons - cytology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Neuroprotective Agents - metabolism</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>NGF</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Septal Nuclei - drug effects</topic><topic>Septal Nuclei - growth & development</topic><topic>Septal Nuclei - metabolism</topic><topic>Septum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, M</creatorcontrib><creatorcontrib>Tian, X</creatorcontrib><creatorcontrib>Suszkiw, J.B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, M</au><au>Tian, X</au><au>Suszkiw, J.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental stage-dependent protective effect of NGF against lead cholinotoxicity in the rat septum</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2000-06-02</date><risdate>2000</risdate><volume>866</volume><issue>1</issue><spage>268</spage><epage>273</epage><pages>268-273</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The ability of nerve growth factor (NGF) to ameliorate developmental cholinotoxicity of inorganic lead (Pb) for the septal neurons was investigated by making intracerebroventricular injections of single doses of 30 μg 2.5S NGF into maternally lead-exposed suckling rats on postnatal days P2, P4, P11, or P18. Administration of NGF on P4 or later induced septal choline acetyltransferase (ChAT) activity to the same relative extent in both Pb-exposed as in control rats but failed to reverse the net reductions of ChAT activity induced by Pb. In contrast, injection of NGF at P2 completely restored ChAT activity in Pb-exposed pups to control levels by preventing the loss of ChAT-immunoreactive cells in the septum. It is concluded that although NGF retains the capacity to upregulate ChAT throughout the period of Pb exposure, it protects against the Pb-induced loss of septal cholinergic neurons only when applied within the critical period of Pb-vulnerability between postnatal days 2 and 4.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>10825503</pmid><doi>10.1016/S0006-8993(00)02265-4</doi><tpages>6</tpages></addata></record> |
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| subjects | Acetylcholine - metabolism Age Factors Animals Animals, Newborn Biological and medical sciences Choline O-Acetyltransferase - metabolism Cholineacetyltransferase Cholinergic Fibers - drug effects Cholinergic Fibers - metabolism Cholinergic Fibers - ultrastructure Cholinergic neurons Development Female Lead - toxicity Lead cholinotoxicity Lead Poisoning, Nervous System, Childhood - drug therapy Lead Poisoning, Nervous System, Childhood - physiopathology Maternal Exposure - adverse effects Medical sciences Nerve Growth Factor - metabolism Nerve Growth Factor - pharmacology Neurons - cytology Neurons - drug effects Neurons - metabolism Neuropharmacology Neuroprotective agent Neuroprotective Agents - metabolism Neuroprotective Agents - pharmacology NGF Pharmacology. Drug treatments Pregnancy Rats Rats, Sprague-Dawley Septal Nuclei - drug effects Septal Nuclei - growth & development Septal Nuclei - metabolism Septum |
| title | Developmental stage-dependent protective effect of NGF against lead cholinotoxicity in the rat septum |
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