Protection Induced in Mice Vaccinated with Recombinant Collagen-Binding Protein (CnBP) and Alpha-Toxoid against Intramammary Infection with Staphylococcus aureus
Mice vaccinated with a combination of two Staphylococcus aureus antigens consisting of a recombinant collagen-binding protein (CnBP) and alpha-toxoid (α-toxoid) were significantly protected from intramammary challenge infection with S. aureus. The average number of bacteria recovered from the glands...
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| Veröffentlicht in: | MICROBIOLOGY and IMMUNOLOGY 2000, Vol.44(5), pp.381-384 |
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| creator | Mamo, Wubshet Fröman, Gunnar Müller, Hans-peter |
| description | Mice vaccinated with a combination of two Staphylococcus aureus antigens consisting of a recombinant collagen-binding protein (CnBP) and alpha-toxoid (α-toxoid) were significantly protected from intramammary challenge infection with S. aureus. The average number of bacteria recovered from the glands of mice vaccinated with the combination of CnBP/α-toxoid was significantly lower compared to the average number of bacteria recovered from the glands of mice vaccinated with only CnBP or α-toxoid or controls (P≤0.01). Histopathological examination of mammary glands of mice vaccinated with CnBP together with α-toxoid showed no pathological changes, whereas glands of mice vaccinated with CnBP or α-toxoid alone developed severe mastitis and showed both focal and disseminated necrosis. |
| doi_str_mv | 10.1111/j.1348-0421.2000.tb02509.x |
| format | Article |
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The average number of bacteria recovered from the glands of mice vaccinated with the combination of CnBP/α-toxoid was significantly lower compared to the average number of bacteria recovered from the glands of mice vaccinated with only CnBP or α-toxoid or controls (P≤0.01). Histopathological examination of mammary glands of mice vaccinated with CnBP together with α-toxoid showed no pathological changes, whereas glands of mice vaccinated with CnBP or α-toxoid alone developed severe mastitis and showed both focal and disseminated necrosis.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/j.1348-0421.2000.tb02509.x</identifier><identifier>PMID: 10888356</identifier><identifier>CODEN: MIIMDV</identifier><language>eng</language><publisher>Tokyo: Blackwell Publishing Ltd</publisher><subject>a-Toxoid ; Animals ; Bacteriology ; Biological and medical sciences ; Collagen-binding protein ; Drug Synergism ; Female ; Fundamental and applied biological sciences. Psychology ; Integrins - chemistry ; Integrins - genetics ; Integrins - immunology ; Mammary Glands, Animal - microbiology ; Mammary Glands, Animal - pathology ; Mastitis ; Mastitis - immunology ; Mastitis - microbiology ; Mastitis - prevention & control ; Mice ; Microbiology ; Pregnancy ; Receptors, Collagen ; Recombinant Fusion Proteins - genetics ; Recombinant Fusion Proteins - immunology ; Staphylococcal Infections - immunology ; Staphylococcal Infections - microbiology ; Staphylococcal Infections - prevention & control ; Staphylococcal Toxoid - chemistry ; Staphylococcal Toxoid - immunology ; Staphylococcal Vaccines - immunology ; Staphylococcus aureus ; Staphylococcus aureus - chemistry ; Vaccine ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><ispartof>MICROBIOLOGY and IMMUNOLOGY, 2000, Vol.44(5), pp.381-384</ispartof><rights>Center for Academic Publications Japan</rights><rights>owned by Center for Academic Publications Japan (Publisher)</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6139-aea092a84659516f4a057971a7344fd80de77000ba4662439d224fe8aba9580d3</citedby><cites>FETCH-LOGICAL-c6139-aea092a84659516f4a057971a7344fd80de77000ba4662439d224fe8aba9580d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1348-0421.2000.tb02509.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1348-0421.2000.tb02509.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,1883,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1447292$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10888356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mamo, Wubshet</creatorcontrib><creatorcontrib>Fröman, Gunnar</creatorcontrib><creatorcontrib>Müller, Hans-peter</creatorcontrib><title>Protection Induced in Mice Vaccinated with Recombinant Collagen-Binding Protein (CnBP) and Alpha-Toxoid against Intramammary Infection with Staphylococcus aureus</title><title>MICROBIOLOGY and IMMUNOLOGY</title><addtitle>Microbiology and Immunology</addtitle><description>Mice vaccinated with a combination of two Staphylococcus aureus antigens consisting of a recombinant collagen-binding protein (CnBP) and alpha-toxoid (α-toxoid) were significantly protected from intramammary challenge infection with S. aureus. The average number of bacteria recovered from the glands of mice vaccinated with the combination of CnBP/α-toxoid was significantly lower compared to the average number of bacteria recovered from the glands of mice vaccinated with only CnBP or α-toxoid or controls (P≤0.01). Histopathological examination of mammary glands of mice vaccinated with CnBP together with α-toxoid showed no pathological changes, whereas glands of mice vaccinated with CnBP or α-toxoid alone developed severe mastitis and showed both focal and disseminated necrosis.</description><subject>a-Toxoid</subject><subject>Animals</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Collagen-binding protein</subject><subject>Drug Synergism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Integrins - chemistry</subject><subject>Integrins - genetics</subject><subject>Integrins - immunology</subject><subject>Mammary Glands, Animal - microbiology</subject><subject>Mammary Glands, Animal - pathology</subject><subject>Mastitis</subject><subject>Mastitis - immunology</subject><subject>Mastitis - microbiology</subject><subject>Mastitis - prevention & control</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Pregnancy</subject><subject>Receptors, Collagen</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>Recombinant Fusion Proteins - immunology</subject><subject>Staphylococcal Infections - immunology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal Infections - prevention & control</subject><subject>Staphylococcal Toxoid - chemistry</subject><subject>Staphylococcal Toxoid - immunology</subject><subject>Staphylococcal Vaccines - immunology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - chemistry</subject><subject>Vaccine</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd9u0zAUxiMEYmPwCshCCMFFiv8lTrhiq7ZSaYWJDZC4sU4dp3VJ7BI7Wvs4vCluU5XdkgvHPuc7vy_OlySvCB6R-LxfjQjjRYo5JSOKMR6FOaYZLkebR8npsfU4OcWsyNIsx_gkeeb9CmMqaMGfJicEF0XBsvw0-XPTuaBVMM6iqa16pStkLJoZpdF3UMpYCLF0b8ISfdXKtfNYsQGNXdPAQtv0wtjK2AXac-Lk27G9uHmHwFbovFkvIb1zG2cqBAsw1odoEjpooW2h28ZDffDeG9wGWC-3jVNOqd4j6Dvd--fJkxoar18c3mfJt6vLu_Gn9PrLZDo-v05VTliZggZcUih4npUZyWsOOBOlICAY53VV4EoLEX_WHHieU87KilJe6wLmUGaxy86SNwN33bnfvfZBtsYrHa9pteu9JCLH0YhF4YdBqDrnfadrue7M7jqSYLkLSK7kLgW5S0HuApKHgOQmDr88uPTzVlcPRodEouD1QQBeQVN3YJXx_3ScC1rSKPs4yO5No7f_8QVyNp3ttxFxOSBWPsQojwzoglGNlm3M0JBSCMm5zIaFFeTYV0vopLaRkw4c44PePMD8krlgIpM_Pk_kJBPF1e14In-yvxP21t0</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Mamo, Wubshet</creator><creator>Fröman, Gunnar</creator><creator>Müller, Hans-peter</creator><general>Blackwell Publishing Ltd</general><general>Center For Academic Publications Japan</general><general>Center for Academic Publications Japan</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20000101</creationdate><title>Protection Induced in Mice Vaccinated with Recombinant Collagen-Binding Protein (CnBP) and Alpha-Toxoid against Intramammary Infection with Staphylococcus aureus</title><author>Mamo, Wubshet ; Fröman, Gunnar ; Müller, Hans-peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6139-aea092a84659516f4a057971a7344fd80de77000ba4662439d224fe8aba9580d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>a-Toxoid</topic><topic>Animals</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Collagen-binding protein</topic><topic>Drug Synergism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Integrins - chemistry</topic><topic>Integrins - genetics</topic><topic>Integrins - immunology</topic><topic>Mammary Glands, Animal - microbiology</topic><topic>Mammary Glands, Animal - pathology</topic><topic>Mastitis</topic><topic>Mastitis - immunology</topic><topic>Mastitis - microbiology</topic><topic>Mastitis - prevention & control</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Pregnancy</topic><topic>Receptors, Collagen</topic><topic>Recombinant Fusion Proteins - genetics</topic><topic>Recombinant Fusion Proteins - immunology</topic><topic>Staphylococcal Infections - immunology</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal Infections - prevention & control</topic><topic>Staphylococcal Toxoid - chemistry</topic><topic>Staphylococcal Toxoid - immunology</topic><topic>Staphylococcal Vaccines - immunology</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - chemistry</topic><topic>Vaccine</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mamo, Wubshet</creatorcontrib><creatorcontrib>Fröman, Gunnar</creatorcontrib><creatorcontrib>Müller, Hans-peter</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>MICROBIOLOGY and IMMUNOLOGY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mamo, Wubshet</au><au>Fröman, Gunnar</au><au>Müller, Hans-peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection Induced in Mice Vaccinated with Recombinant Collagen-Binding Protein (CnBP) and Alpha-Toxoid against Intramammary Infection with Staphylococcus aureus</atitle><jtitle>MICROBIOLOGY and IMMUNOLOGY</jtitle><addtitle>Microbiology and Immunology</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>44</volume><issue>5</issue><spage>381</spage><epage>384</epage><pages>381-384</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><coden>MIIMDV</coden><abstract>Mice vaccinated with a combination of two Staphylococcus aureus antigens consisting of a recombinant collagen-binding protein (CnBP) and alpha-toxoid (α-toxoid) were significantly protected from intramammary challenge infection with S. aureus. The average number of bacteria recovered from the glands of mice vaccinated with the combination of CnBP/α-toxoid was significantly lower compared to the average number of bacteria recovered from the glands of mice vaccinated with only CnBP or α-toxoid or controls (P≤0.01). Histopathological examination of mammary glands of mice vaccinated with CnBP together with α-toxoid showed no pathological changes, whereas glands of mice vaccinated with CnBP or α-toxoid alone developed severe mastitis and showed both focal and disseminated necrosis.</abstract><cop>Tokyo</cop><pub>Blackwell Publishing Ltd</pub><pmid>10888356</pmid><doi>10.1111/j.1348-0421.2000.tb02509.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0385-5600 |
| ispartof | MICROBIOLOGY and IMMUNOLOGY, 2000, Vol.44(5), pp.381-384 |
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| source | MEDLINE; Access via Wiley Online Library; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | a-Toxoid Animals Bacteriology Biological and medical sciences Collagen-binding protein Drug Synergism Female Fundamental and applied biological sciences. Psychology Integrins - chemistry Integrins - genetics Integrins - immunology Mammary Glands, Animal - microbiology Mammary Glands, Animal - pathology Mastitis Mastitis - immunology Mastitis - microbiology Mastitis - prevention & control Mice Microbiology Pregnancy Receptors, Collagen Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Staphylococcal Infections - immunology Staphylococcal Infections - microbiology Staphylococcal Infections - prevention & control Staphylococcal Toxoid - chemistry Staphylococcal Toxoid - immunology Staphylococcal Vaccines - immunology Staphylococcus aureus Staphylococcus aureus - chemistry Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies |
| title | Protection Induced in Mice Vaccinated with Recombinant Collagen-Binding Protein (CnBP) and Alpha-Toxoid against Intramammary Infection with Staphylococcus aureus |
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