Inhibitory effects of IFN-gamma and acyclovir on the glioblastoma cell cycle

Glioblastoma multiforme is one of the most aggressive and frequently occurring forms of brain cancer. It originates from astrocytes and is characterized by a loss of cell cycle control frequently involving mutations in tumor suppressor genes, such as p53 and p16. Nucleoside analogs, such as acyclovi...

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Veröffentlicht in:	Journal of interferon & cytokine research 2000-05, Vol.20 (5), p.463-469
Hauptverfasser:	Kominsky, S L, Subramaniam, P S, Johnson, H M, Torres, B A
Format:	Artikel
Sprache:	eng
Schlagworte:	acyclovir Acyclovir - administration & dosage Antiviral Agents - administration & dosage Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology CDC2-CDC28 Kinases Cell Cycle - drug effects Cell Division - drug effects Cell Line Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinases - metabolism Cyclins - metabolism Drug Synergism g-Interferon glioblastoma Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Humans Interferon-gamma - administration & dosage Proliferating Cell Nuclear Antigen - metabolism Protein-Serine-Threonine Kinases - metabolism Recombinant Proteins Tumor Cells, Cultured
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