An evaluation of engraftment, toxicity and busulfan concentration in children receiving bone marrow transplantation for leukemia or genetic disease

Autologous recovery is a major problem with busulfan as a marrow ablative agent in conditioning children for allogeneic BMT. Data suggest the average concentration of busulfan at steady state (Bu Css) is critical for successful engraftment. We prospectively evaluated busulfan pharmacokinetics in 31...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2000-05, Vol.25 (9), p.925-930
Hauptverfasser:	BOLINGER, A. M, ZANGWILL, A. B, SLATTERY, J. T, GLIDDEN, D, DESANTES, K, HEYN, L, RISLER, L. J, BOSTROM, B, COWAN, M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Acute myeloid leukemia Adolescent Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Autografts Biological and medical sciences Bone marrow Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Busulfan Busulfan - administration & dosage Busulfan - blood Busulfan - pharmacokinetics Child Child, Preschool Children Chimerism Cyclophosphamide Engraftment Female Genetic Diseases, Inborn - blood Genetic Diseases, Inborn - therapy Genetic disorders Graft Survival Histocompatibility antigen HLA Histocompatibility Testing Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - blood Immunosuppressive Agents - pharmacokinetics Infant Leukemia Leukemia - blood Leukemia - therapy Male Medical sciences Pharmacokinetics Pharmacology Prospective Studies Recovery Stem cell transplantation Toxicity Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Homologous
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