Targeting of Lung Cancer Mutational Hotspots by Polycyclic Aromatic Hydrocarbons

Background: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in combustion products of organic matter, including cigarette smoke. Metabolically activated diol epoxides of these compounds, including benzo[a]pyrene diol epoxide (B[a]PDE), have been suggested as causative agents in the developmen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2000-05, Vol.92 (10), p.803-811
Hauptverfasser:	Smith, Leslie E., Denissenko, Mikhail F., Bennett, William P., Li, Haiying, Amin, Shantu, Tang, Moon-shong, Pfeifer, Gerd P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Benzopyrenes - adverse effects Biological and medical sciences Bronchi - drug effects Bronchi - metabolism Carcinogens - adverse effects Cells, Cultured Chrysenes - adverse effects Codon DNA Adducts Epithelial Cells - drug effects Epoxy Compounds - adverse effects Genes, p53 Lung cancer Lung Neoplasms - chemically induced Medical research Medical sciences Mutation Phenanthrenes - adverse effects Pneumology Polycyclic Aromatic Hydrocarbons - adverse effects Tumors of the respiratory system and mediastinum
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!