Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1

Carbon monoxide (CO), a product of heme oxygenase activity, exerts antiapoptotic and anti-inflammatory effects in vitro and in vivo. The anti-inflammatory effects of CO involve the inhibition of TNF-alpha expression and the enhancement of IL-10 production, resulting in reduced mortality after endoto...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-08, Vol.175 (4), p.2622-2629
Hauptverfasser:	Kim, Hong Pyo, Wang, Xue, Zhang, Jinglan, Suh, Gee Young, Benjamin, Ivor J, Ryter, Stefan W, Choi, Augustine M K
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - physiology Animals Apoptosis - genetics Apoptosis - physiology Carbon Monoxide - metabolism Carbon Monoxide - physiology Carbon Monoxide - therapeutic use Cells, Cultured Cytoprotection - genetics Cytoprotection - physiology DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Endothelial Cells - cytology Endothelial Cells - enzymology Endothelial Cells - metabolism Enzyme Activation - physiology Female Fibroblasts - cytology Fibroblasts - enzymology Fibroblasts - metabolism Heat Shock Transcription Factors HSP70 Heat-Shock Proteins - biosynthesis HSP70 Heat-Shock Proteins - physiology Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - toxicity Lung - cytology Lung - enzymology Lung - metabolism Male Mice Mice, Inbred BALB C Mice, Knockout Mitogen-Activated Protein Kinase 11 - deficiency Mitogen-Activated Protein Kinase 11 - genetics Mitogen-Activated Protein Kinase 11 - metabolism Mitogen-Activated Protein Kinase 11 - physiology Shock, Septic - genetics Shock, Septic - metabolism Shock, Septic - prevention & control Survival Rate Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - physiology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - physiology Up-Regulation - physiology
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