Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1
Carbon monoxide (CO), a product of heme oxygenase activity, exerts antiapoptotic and anti-inflammatory effects in vitro and in vivo. The anti-inflammatory effects of CO involve the inhibition of TNF-alpha expression and the enhancement of IL-10 production, resulting in reduced mortality after endoto...
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| Veröffentlicht in: | The Journal of immunology (1950) 2005-08, Vol.175 (4), p.2622-2629 |
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| container_title | The Journal of immunology (1950) |
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| creator | Kim, Hong Pyo Wang, Xue Zhang, Jinglan Suh, Gee Young Benjamin, Ivor J Ryter, Stefan W Choi, Augustine M K |
| description | Carbon monoxide (CO), a product of heme oxygenase activity, exerts antiapoptotic and anti-inflammatory effects in vitro and in vivo. The anti-inflammatory effects of CO involve the inhibition of TNF-alpha expression and the enhancement of IL-10 production, resulting in reduced mortality after endotoxin challenge. In this study we demonstrate for the first time that the protective effects of CO involve the increased expression of the 70-kDa inducible heat shock protein (Hsp70) in murine lung endothelial cells and fibroblasts. The p38beta MAPK mediated the effects of CO on cytoprotection and Hsp70 regulation. Suppression of Hsp70 expression and/or genetic deletion of heat shock factor-1, the principle transcriptional regulator of Hsp70, attenuated the cytoprotective and immunomodulatory effects of CO in mouse lung cells and in vivo. These data provide a novel mechanism for the protective effects of CO and underscore a potential application of this gaseous molecule in anti-inflammatory therapies. |
| doi_str_mv | 10.4049/jimmunol.175.4.2622 |
| format | Article |
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The anti-inflammatory effects of CO involve the inhibition of TNF-alpha expression and the enhancement of IL-10 production, resulting in reduced mortality after endotoxin challenge. In this study we demonstrate for the first time that the protective effects of CO involve the increased expression of the 70-kDa inducible heat shock protein (Hsp70) in murine lung endothelial cells and fibroblasts. The p38beta MAPK mediated the effects of CO on cytoprotection and Hsp70 regulation. Suppression of Hsp70 expression and/or genetic deletion of heat shock factor-1, the principle transcriptional regulator of Hsp70, attenuated the cytoprotective and immunomodulatory effects of CO in mouse lung cells and in vivo. These data provide a novel mechanism for the protective effects of CO and underscore a potential application of this gaseous molecule in anti-inflammatory therapies.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.175.4.2622</identifier><identifier>PMID: 16081837</identifier><language>eng</language><publisher>United States</publisher><subject>Active Transport, Cell Nucleus - physiology ; Animals ; Apoptosis - genetics ; Apoptosis - physiology ; Carbon Monoxide - metabolism ; Carbon Monoxide - physiology ; Carbon Monoxide - therapeutic use ; Cells, Cultured ; Cytoprotection - genetics ; Cytoprotection - physiology ; DNA-Binding Proteins - deficiency ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - physiology ; Endothelial Cells - cytology ; Endothelial Cells - enzymology ; Endothelial Cells - metabolism ; Enzyme Activation - physiology ; Female ; Fibroblasts - cytology ; Fibroblasts - enzymology ; Fibroblasts - metabolism ; Heat Shock Transcription Factors ; HSP70 Heat-Shock Proteins - biosynthesis ; HSP70 Heat-Shock Proteins - physiology ; Lipopolysaccharides - antagonists & inhibitors ; Lipopolysaccharides - toxicity ; Lung - cytology ; Lung - enzymology ; Lung - metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Mitogen-Activated Protein Kinase 11 - deficiency ; Mitogen-Activated Protein Kinase 11 - genetics ; Mitogen-Activated Protein Kinase 11 - metabolism ; Mitogen-Activated Protein Kinase 11 - physiology ; Shock, Septic - genetics ; Shock, Septic - metabolism ; Shock, Septic - prevention & control ; Survival Rate ; Transcription Factors - deficiency ; Transcription Factors - genetics ; Transcription Factors - physiology ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Tumor Necrosis Factor-alpha - physiology ; Up-Regulation - physiology</subject><ispartof>The Journal of immunology (1950), 2005-08, Vol.175 (4), p.2622-2629</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-66f155278527daa4416c40bd0ff5b87deab682307f042a4961303d431384d2333</citedby><cites>FETCH-LOGICAL-c379t-66f155278527daa4416c40bd0ff5b87deab682307f042a4961303d431384d2333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16081837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hong Pyo</creatorcontrib><creatorcontrib>Wang, Xue</creatorcontrib><creatorcontrib>Zhang, Jinglan</creatorcontrib><creatorcontrib>Suh, Gee Young</creatorcontrib><creatorcontrib>Benjamin, Ivor J</creatorcontrib><creatorcontrib>Ryter, Stefan W</creatorcontrib><creatorcontrib>Choi, Augustine M K</creatorcontrib><title>Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Carbon monoxide (CO), a product of heme oxygenase activity, exerts antiapoptotic and anti-inflammatory effects in vitro and in vivo. The anti-inflammatory effects of CO involve the inhibition of TNF-alpha expression and the enhancement of IL-10 production, resulting in reduced mortality after endotoxin challenge. In this study we demonstrate for the first time that the protective effects of CO involve the increased expression of the 70-kDa inducible heat shock protein (Hsp70) in murine lung endothelial cells and fibroblasts. The p38beta MAPK mediated the effects of CO on cytoprotection and Hsp70 regulation. Suppression of Hsp70 expression and/or genetic deletion of heat shock factor-1, the principle transcriptional regulator of Hsp70, attenuated the cytoprotective and immunomodulatory effects of CO in mouse lung cells and in vivo. These data provide a novel mechanism for the protective effects of CO and underscore a potential application of this gaseous molecule in anti-inflammatory therapies.</description><subject>Active Transport, Cell Nucleus - physiology</subject><subject>Animals</subject><subject>Apoptosis - genetics</subject><subject>Apoptosis - physiology</subject><subject>Carbon Monoxide - metabolism</subject><subject>Carbon Monoxide - physiology</subject><subject>Carbon Monoxide - therapeutic use</subject><subject>Cells, Cultured</subject><subject>Cytoprotection - genetics</subject><subject>Cytoprotection - physiology</subject><subject>DNA-Binding Proteins - deficiency</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Endothelial Cells - cytology</subject><subject>Endothelial Cells - enzymology</subject><subject>Endothelial Cells - metabolism</subject><subject>Enzyme Activation - physiology</subject><subject>Female</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - enzymology</subject><subject>Fibroblasts - metabolism</subject><subject>Heat Shock Transcription Factors</subject><subject>HSP70 Heat-Shock Proteins - biosynthesis</subject><subject>HSP70 Heat-Shock Proteins - physiology</subject><subject>Lipopolysaccharides - antagonists & inhibitors</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Lung - cytology</subject><subject>Lung - enzymology</subject><subject>Lung - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Knockout</subject><subject>Mitogen-Activated Protein Kinase 11 - deficiency</subject><subject>Mitogen-Activated Protein Kinase 11 - genetics</subject><subject>Mitogen-Activated Protein Kinase 11 - metabolism</subject><subject>Mitogen-Activated Protein Kinase 11 - physiology</subject><subject>Shock, Septic - genetics</subject><subject>Shock, Septic - metabolism</subject><subject>Shock, Septic - prevention & control</subject><subject>Survival Rate</subject><subject>Transcription Factors - deficiency</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - physiology</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><subject>Up-Regulation - physiology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EgvL4AiTkFbuU8SN2yg4hoAgQLGAdOc5YDSRxid2KLvlz3FLEYjQj3bkzuoeQUwZjCXJy8d503aL37ZjpfCzHXHG-Q0YszyFTCtQuGQFwnjGt9AE5DOEdABRwuU8OmIKCFUKPyPcUTaRh5u0HnQ8-YtNnGmiHdWMiBhpnSO0q-o1mY7NEis6liXpHrRkq39PO9_6rqfGSNv3St0vssN_oc1HQCqOhT1cvD9T0NZ39f3PGRj9k7JjsOdMGPNn2I_J2e_N6Pc0en-_ur68eMyv0JKZILkXjukhVGyMlU1ZCVYNzeVXoGk2lCi5AO5DcyIliAkQtBROFrLkQ4oic_95NUT4XGGLZNcFi25oe_SKUieJEaZmnRfG7aAcfwoCunA9NZ4ZVyaBcky__yK89pSzX5JPrbHt-USV6_54tavEDFeWBJA</recordid><startdate>20050815</startdate><enddate>20050815</enddate><creator>Kim, Hong Pyo</creator><creator>Wang, Xue</creator><creator>Zhang, Jinglan</creator><creator>Suh, Gee Young</creator><creator>Benjamin, Ivor J</creator><creator>Ryter, Stefan W</creator><creator>Choi, Augustine M K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20050815</creationdate><title>Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1</title><author>Kim, Hong Pyo ; Wang, Xue ; Zhang, Jinglan ; Suh, Gee Young ; Benjamin, Ivor J ; Ryter, Stefan W ; Choi, Augustine M K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-66f155278527daa4416c40bd0ff5b87deab682307f042a4961303d431384d2333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Active Transport, Cell Nucleus - physiology</topic><topic>Animals</topic><topic>Apoptosis - genetics</topic><topic>Apoptosis - physiology</topic><topic>Carbon Monoxide - metabolism</topic><topic>Carbon Monoxide - physiology</topic><topic>Carbon Monoxide - therapeutic use</topic><topic>Cells, Cultured</topic><topic>Cytoprotection - genetics</topic><topic>Cytoprotection - physiology</topic><topic>DNA-Binding Proteins - deficiency</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Endothelial Cells - cytology</topic><topic>Endothelial Cells - enzymology</topic><topic>Endothelial Cells - metabolism</topic><topic>Enzyme Activation - physiology</topic><topic>Female</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - enzymology</topic><topic>Fibroblasts - metabolism</topic><topic>Heat Shock Transcription Factors</topic><topic>HSP70 Heat-Shock Proteins - biosynthesis</topic><topic>HSP70 Heat-Shock Proteins - physiology</topic><topic>Lipopolysaccharides - antagonists & inhibitors</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Lung - cytology</topic><topic>Lung - enzymology</topic><topic>Lung - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Knockout</topic><topic>Mitogen-Activated Protein Kinase 11 - deficiency</topic><topic>Mitogen-Activated Protein Kinase 11 - genetics</topic><topic>Mitogen-Activated Protein Kinase 11 - metabolism</topic><topic>Mitogen-Activated Protein Kinase 11 - physiology</topic><topic>Shock, Septic - genetics</topic><topic>Shock, Septic - metabolism</topic><topic>Shock, Septic - prevention & control</topic><topic>Survival Rate</topic><topic>Transcription Factors - deficiency</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - physiology</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Tumor Necrosis Factor-alpha - physiology</topic><topic>Up-Regulation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hong Pyo</creatorcontrib><creatorcontrib>Wang, Xue</creatorcontrib><creatorcontrib>Zhang, Jinglan</creatorcontrib><creatorcontrib>Suh, Gee Young</creatorcontrib><creatorcontrib>Benjamin, Ivor J</creatorcontrib><creatorcontrib>Ryter, Stefan W</creatorcontrib><creatorcontrib>Choi, Augustine M K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hong Pyo</au><au>Wang, Xue</au><au>Zhang, Jinglan</au><au>Suh, Gee Young</au><au>Benjamin, Ivor J</au><au>Ryter, Stefan W</au><au>Choi, Augustine M K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2005-08-15</date><risdate>2005</risdate><volume>175</volume><issue>4</issue><spage>2622</spage><epage>2629</epage><pages>2622-2629</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Carbon monoxide (CO), a product of heme oxygenase activity, exerts antiapoptotic and anti-inflammatory effects in vitro and in vivo. The anti-inflammatory effects of CO involve the inhibition of TNF-alpha expression and the enhancement of IL-10 production, resulting in reduced mortality after endotoxin challenge. In this study we demonstrate for the first time that the protective effects of CO involve the increased expression of the 70-kDa inducible heat shock protein (Hsp70) in murine lung endothelial cells and fibroblasts. The p38beta MAPK mediated the effects of CO on cytoprotection and Hsp70 regulation. Suppression of Hsp70 expression and/or genetic deletion of heat shock factor-1, the principle transcriptional regulator of Hsp70, attenuated the cytoprotective and immunomodulatory effects of CO in mouse lung cells and in vivo. These data provide a novel mechanism for the protective effects of CO and underscore a potential application of this gaseous molecule in anti-inflammatory therapies.</abstract><cop>United States</cop><pmid>16081837</pmid><doi>10.4049/jimmunol.175.4.2622</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of immunology (1950), 2005-08, Vol.175 (4), p.2622-2629 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Active Transport, Cell Nucleus - physiology Animals Apoptosis - genetics Apoptosis - physiology Carbon Monoxide - metabolism Carbon Monoxide - physiology Carbon Monoxide - therapeutic use Cells, Cultured Cytoprotection - genetics Cytoprotection - physiology DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Endothelial Cells - cytology Endothelial Cells - enzymology Endothelial Cells - metabolism Enzyme Activation - physiology Female Fibroblasts - cytology Fibroblasts - enzymology Fibroblasts - metabolism Heat Shock Transcription Factors HSP70 Heat-Shock Proteins - biosynthesis HSP70 Heat-Shock Proteins - physiology Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - toxicity Lung - cytology Lung - enzymology Lung - metabolism Male Mice Mice, Inbred BALB C Mice, Knockout Mitogen-Activated Protein Kinase 11 - deficiency Mitogen-Activated Protein Kinase 11 - genetics Mitogen-Activated Protein Kinase 11 - metabolism Mitogen-Activated Protein Kinase 11 - physiology Shock, Septic - genetics Shock, Septic - metabolism Shock, Septic - prevention & control Survival Rate Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - physiology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - physiology Up-Regulation - physiology |
| title | Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1 |
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