Prophylactic activity of atovaquone against Plasmodium falciparum in humans

The prophylactic antimalarial activity of atovaquone was determined in a randomized, double-blind, placebo-controlled study of healthy volunteers who were challenged by the bite of Plasmodium falciparum-infected Anopheles stephensi. Subjects were randomly assigned to one of three groups: six receive...

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Veröffentlicht in:	The American journal of tropical medicine and hygiene 1999-05, Vol.60 (5), p.831-836
Hauptverfasser:	Shapiro, TA, Ranasinha, CD, Kumar, N, Barditch-Crovo, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Anopheles - parasitology Anopheles - physiology Anopheles stephensi Antimalarials - adverse effects Antimalarials - pharmacokinetics Antimalarials - therapeutic use Atovaquone Double-Blind Method Humans Insect Bites and Stings Malaria, Falciparum - immunology Malaria, Falciparum - prevention & control Middle Aged Naphthoquinones - adverse effects Naphthoquinones - pharmacokinetics Naphthoquinones - therapeutic use parasitemia Parasitemia - parasitology Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - isolation & purification Polymerase Chain Reaction - methods
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