Effect of Hormone replacement therapy on breast cancer risk : Estrogen versus estrogen plus progestin
Hormone replacement therapy (HRT) given as unopposed estrogen replacement therapy (ERT) gained widespread popularity in the United States in the 1960s and 1970s. Recent prescribing practices have favored combination HRT (CHRT), i.e., adding a progestin to estrogen for the entire monthly cycle (conti...
Gespeichert in:
| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 2000-02, Vol.92 (4), p.328-332 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 332 |
|---|---|
| container_issue | 4 |
| container_start_page | 328 |
| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 92 |
| creator | ROSS, R. K PAGANINI-HILL, A WAN, P. C PIKE, M. C |
| description | Hormone replacement therapy (HRT) given as unopposed estrogen replacement therapy (ERT) gained widespread popularity in the United States in the 1960s and 1970s. Recent prescribing practices have favored combination HRT (CHRT), i.e., adding a progestin to estrogen for the entire monthly cycle (continuous combined replacement therapy [CCRT]) or a part of the cycle (sequential estrogen plus progestin therapy [SEPRT]). Few data exist on the association between CHRT and breast cancer risk. We determined the effects of CHRT on a woman's risk of developing breast cancer in a population-based, case-control study.
Case subjects included those with incident breast cancers diagnosed over 4(1/2) years in Los Angeles County, CA, in the late 1980s and 1990s. Control subjects were neighborhood residents who were individually matched to case subjects on age and race. Case subjects and control subjects were interviewed in person to collect information on known breast cancer risk factors as well as on HRT use. Information on 1897 postmenopausal case subjects and on 1637 postmenopausal control subjects aged 55-72 years who had not undergone a simple hysterectomy was analyzed. Breast cancer risks associated with the various types of HRT were estimated as odds ratios (ORs) after adjusting simultaneously for the different forms of HRT and for known risk factors of breast cancer. All P values are two-sided.
HRT was associated with a 10% higher breast cancer risk for each 5 years of use (OR(5) = 1.10; 95% confidence interval [CI] = 1.02-1.18). Risk was substantially higher for CHRT use (OR(5) = 1.24; 95% CI = 1.07-1.45) than for ERT use (OR(5) = 1. 06; 95% CI = 0.97-1.15). Risk estimates were higher for SEPRT (OR(5) = 1.38; 95% CI = 1.13-1.68) than for CCRT (OR(5) = 1.09; 95% CI = 0. 88-1.35), but this difference was not statistically significant.
This study provides strong evidence that the addition of a progestin to HRT enhances markedly the risk of breast cancer relative to estrogen use alone. These findings have important implications for the risk-benefit equation for HRT in women using CHRT. |
| doi_str_mv | 10.1093/jnci/92.4.328 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17590306</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>49960667</sourcerecordid><originalsourceid>FETCH-LOGICAL-c506t-758939e1f5ec9b773a09391120447008386fe029130a546847cc1f95a5717b2d3</originalsourceid><addsrcrecordid>eNpdkEtr3DAQgEVJaTZpj7kWEUpu3oxeltRbCdukEOilPQutMmq8tWVXsgP599WyWxoyl5mBj3l8hFwwWDOw4nqXQndt-VquBTdvyIrJFhrOQJ2QFQDXjTFanpKzUnZQw3L5jpwyaLUShq8IbmLEMNMx0rsxD2NCmnHqfcAB00znR8x-eqZjotuMvsw0-BQw09yV3_Qz3ZQ5j78w0SfMZSkU__VTX7tpX5e5S-_J2-j7gh-O-Zz8_Lr5cXPX3H-__Xbz5b4JCtq50cpYYZFFhcFutRa-fmgZ4yClBjDCtBGBWybAK9kaqUNg0SqvNNNb_iDOydVhbt38Z6mr3dCVgH3vE45LcUwrCwLaCl6-AnfjklO9zXEOVrfW6Ao1ByjksZSM0U25G3x-dgzcXr7by3eWO-mq_Mp_PA5dtgM-vKAPtivw6Qj4Enwfc3XZlf-cYPU8EH8BeGKL0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220976987</pqid></control><display><type>article</type><title>Effect of Hormone replacement therapy on breast cancer risk : Estrogen versus estrogen plus progestin</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>ROSS, R. K ; PAGANINI-HILL, A ; WAN, P. C ; PIKE, M. C</creator><creatorcontrib>ROSS, R. K ; PAGANINI-HILL, A ; WAN, P. C ; PIKE, M. C</creatorcontrib><description>Hormone replacement therapy (HRT) given as unopposed estrogen replacement therapy (ERT) gained widespread popularity in the United States in the 1960s and 1970s. Recent prescribing practices have favored combination HRT (CHRT), i.e., adding a progestin to estrogen for the entire monthly cycle (continuous combined replacement therapy [CCRT]) or a part of the cycle (sequential estrogen plus progestin therapy [SEPRT]). Few data exist on the association between CHRT and breast cancer risk. We determined the effects of CHRT on a woman's risk of developing breast cancer in a population-based, case-control study.
Case subjects included those with incident breast cancers diagnosed over 4(1/2) years in Los Angeles County, CA, in the late 1980s and 1990s. Control subjects were neighborhood residents who were individually matched to case subjects on age and race. Case subjects and control subjects were interviewed in person to collect information on known breast cancer risk factors as well as on HRT use. Information on 1897 postmenopausal case subjects and on 1637 postmenopausal control subjects aged 55-72 years who had not undergone a simple hysterectomy was analyzed. Breast cancer risks associated with the various types of HRT were estimated as odds ratios (ORs) after adjusting simultaneously for the different forms of HRT and for known risk factors of breast cancer. All P values are two-sided.
HRT was associated with a 10% higher breast cancer risk for each 5 years of use (OR(5) = 1.10; 95% confidence interval [CI] = 1.02-1.18). Risk was substantially higher for CHRT use (OR(5) = 1.24; 95% CI = 1.07-1.45) than for ERT use (OR(5) = 1. 06; 95% CI = 0.97-1.15). Risk estimates were higher for SEPRT (OR(5) = 1.38; 95% CI = 1.13-1.68) than for CCRT (OR(5) = 1.09; 95% CI = 0. 88-1.35), but this difference was not statistically significant.
This study provides strong evidence that the addition of a progestin to HRT enhances markedly the risk of breast cancer relative to estrogen use alone. These findings have important implications for the risk-benefit equation for HRT in women using CHRT.</description><identifier>ISSN: 0027-8874</identifier><identifier>ISSN: 1460-2105</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/92.4.328</identifier><identifier>PMID: 10675382</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Aged ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - chemically induced ; Breast Neoplasms - prevention & control ; California ; Case-Control Studies ; Estrogen Replacement Therapy - adverse effects ; Estrogens ; Estrogens - therapeutic use ; Female ; Gynecology. Andrology. Obstetrics ; Health risk assessment ; hormone replacement therapy ; Hormones ; Humans ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Odds Ratio ; Progestins - therapeutic use ; Risk ; Risk Factors ; Time Factors ; Tumors ; USA, California</subject><ispartof>JNCI : Journal of the National Cancer Institute, 2000-02, Vol.92 (4), p.328-332</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Superintendent of Documents Feb 16, 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-758939e1f5ec9b773a09391120447008386fe029130a546847cc1f95a5717b2d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1315900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10675382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROSS, R. K</creatorcontrib><creatorcontrib>PAGANINI-HILL, A</creatorcontrib><creatorcontrib>WAN, P. C</creatorcontrib><creatorcontrib>PIKE, M. C</creatorcontrib><title>Effect of Hormone replacement therapy on breast cancer risk : Estrogen versus estrogen plus progestin</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>J Natl Cancer Inst</addtitle><description>Hormone replacement therapy (HRT) given as unopposed estrogen replacement therapy (ERT) gained widespread popularity in the United States in the 1960s and 1970s. Recent prescribing practices have favored combination HRT (CHRT), i.e., adding a progestin to estrogen for the entire monthly cycle (continuous combined replacement therapy [CCRT]) or a part of the cycle (sequential estrogen plus progestin therapy [SEPRT]). Few data exist on the association between CHRT and breast cancer risk. We determined the effects of CHRT on a woman's risk of developing breast cancer in a population-based, case-control study.
Case subjects included those with incident breast cancers diagnosed over 4(1/2) years in Los Angeles County, CA, in the late 1980s and 1990s. Control subjects were neighborhood residents who were individually matched to case subjects on age and race. Case subjects and control subjects were interviewed in person to collect information on known breast cancer risk factors as well as on HRT use. Information on 1897 postmenopausal case subjects and on 1637 postmenopausal control subjects aged 55-72 years who had not undergone a simple hysterectomy was analyzed. Breast cancer risks associated with the various types of HRT were estimated as odds ratios (ORs) after adjusting simultaneously for the different forms of HRT and for known risk factors of breast cancer. All P values are two-sided.
HRT was associated with a 10% higher breast cancer risk for each 5 years of use (OR(5) = 1.10; 95% confidence interval [CI] = 1.02-1.18). Risk was substantially higher for CHRT use (OR(5) = 1.24; 95% CI = 1.07-1.45) than for ERT use (OR(5) = 1. 06; 95% CI = 0.97-1.15). Risk estimates were higher for SEPRT (OR(5) = 1.38; 95% CI = 1.13-1.68) than for CCRT (OR(5) = 1.09; 95% CI = 0. 88-1.35), but this difference was not statistically significant.
This study provides strong evidence that the addition of a progestin to HRT enhances markedly the risk of breast cancer relative to estrogen use alone. These findings have important implications for the risk-benefit equation for HRT in women using CHRT.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - chemically induced</subject><subject>Breast Neoplasms - prevention & control</subject><subject>California</subject><subject>Case-Control Studies</subject><subject>Estrogen Replacement Therapy - adverse effects</subject><subject>Estrogens</subject><subject>Estrogens - therapeutic use</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health risk assessment</subject><subject>hormone replacement therapy</subject><subject>Hormones</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Progestins - therapeutic use</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>USA, California</subject><issn>0027-8874</issn><issn>1460-2105</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtr3DAQgEVJaTZpj7kWEUpu3oxeltRbCdukEOilPQutMmq8tWVXsgP599WyWxoyl5mBj3l8hFwwWDOw4nqXQndt-VquBTdvyIrJFhrOQJ2QFQDXjTFanpKzUnZQw3L5jpwyaLUShq8IbmLEMNMx0rsxD2NCmnHqfcAB00znR8x-eqZjotuMvsw0-BQw09yV3_Qz3ZQ5j78w0SfMZSkU__VTX7tpX5e5S-_J2-j7gh-O-Zz8_Lr5cXPX3H-__Xbz5b4JCtq50cpYYZFFhcFutRa-fmgZ4yClBjDCtBGBWybAK9kaqUNg0SqvNNNb_iDOydVhbt38Z6mr3dCVgH3vE45LcUwrCwLaCl6-AnfjklO9zXEOVrfW6Ao1ByjksZSM0U25G3x-dgzcXr7by3eWO-mq_Mp_PA5dtgM-vKAPtivw6Qj4Enwfc3XZlf-cYPU8EH8BeGKL0A</recordid><startdate>20000216</startdate><enddate>20000216</enddate><creator>ROSS, R. K</creator><creator>PAGANINI-HILL, A</creator><creator>WAN, P. C</creator><creator>PIKE, M. C</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope></search><sort><creationdate>20000216</creationdate><title>Effect of Hormone replacement therapy on breast cancer risk : Estrogen versus estrogen plus progestin</title><author>ROSS, R. K ; PAGANINI-HILL, A ; WAN, P. C ; PIKE, M. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-758939e1f5ec9b773a09391120447008386fe029130a546847cc1f95a5717b2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - chemically induced</topic><topic>Breast Neoplasms - prevention & control</topic><topic>California</topic><topic>Case-Control Studies</topic><topic>Estrogen Replacement Therapy - adverse effects</topic><topic>Estrogens</topic><topic>Estrogens - therapeutic use</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Health risk assessment</topic><topic>hormone replacement therapy</topic><topic>Hormones</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Progestins - therapeutic use</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Tumors</topic><topic>USA, California</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROSS, R. K</creatorcontrib><creatorcontrib>PAGANINI-HILL, A</creatorcontrib><creatorcontrib>WAN, P. C</creatorcontrib><creatorcontrib>PIKE, M. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROSS, R. K</au><au>PAGANINI-HILL, A</au><au>WAN, P. C</au><au>PIKE, M. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Hormone replacement therapy on breast cancer risk : Estrogen versus estrogen plus progestin</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>J Natl Cancer Inst</addtitle><date>2000-02-16</date><risdate>2000</risdate><volume>92</volume><issue>4</issue><spage>328</spage><epage>332</epage><pages>328-332</pages><issn>0027-8874</issn><issn>1460-2105</issn><eissn>1460-2105</eissn><coden>JNCIEQ</coden><abstract>Hormone replacement therapy (HRT) given as unopposed estrogen replacement therapy (ERT) gained widespread popularity in the United States in the 1960s and 1970s. Recent prescribing practices have favored combination HRT (CHRT), i.e., adding a progestin to estrogen for the entire monthly cycle (continuous combined replacement therapy [CCRT]) or a part of the cycle (sequential estrogen plus progestin therapy [SEPRT]). Few data exist on the association between CHRT and breast cancer risk. We determined the effects of CHRT on a woman's risk of developing breast cancer in a population-based, case-control study.
Case subjects included those with incident breast cancers diagnosed over 4(1/2) years in Los Angeles County, CA, in the late 1980s and 1990s. Control subjects were neighborhood residents who were individually matched to case subjects on age and race. Case subjects and control subjects were interviewed in person to collect information on known breast cancer risk factors as well as on HRT use. Information on 1897 postmenopausal case subjects and on 1637 postmenopausal control subjects aged 55-72 years who had not undergone a simple hysterectomy was analyzed. Breast cancer risks associated with the various types of HRT were estimated as odds ratios (ORs) after adjusting simultaneously for the different forms of HRT and for known risk factors of breast cancer. All P values are two-sided.
HRT was associated with a 10% higher breast cancer risk for each 5 years of use (OR(5) = 1.10; 95% confidence interval [CI] = 1.02-1.18). Risk was substantially higher for CHRT use (OR(5) = 1.24; 95% CI = 1.07-1.45) than for ERT use (OR(5) = 1. 06; 95% CI = 0.97-1.15). Risk estimates were higher for SEPRT (OR(5) = 1.38; 95% CI = 1.13-1.68) than for CCRT (OR(5) = 1.09; 95% CI = 0. 88-1.35), but this difference was not statistically significant.
This study provides strong evidence that the addition of a progestin to HRT enhances markedly the risk of breast cancer relative to estrogen use alone. These findings have important implications for the risk-benefit equation for HRT in women using CHRT.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>10675382</pmid><doi>10.1093/jnci/92.4.328</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 2000-02, Vol.92 (4), p.328-332 |
| issn | 0027-8874 1460-2105 1460-2105 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17590306 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Biological and medical sciences Breast cancer Breast Neoplasms - chemically induced Breast Neoplasms - prevention & control California Case-Control Studies Estrogen Replacement Therapy - adverse effects Estrogens Estrogens - therapeutic use Female Gynecology. Andrology. Obstetrics Health risk assessment hormone replacement therapy Hormones Humans Mammary gland diseases Medical sciences Middle Aged Odds Ratio Progestins - therapeutic use Risk Risk Factors Time Factors Tumors USA, California |
| title | Effect of Hormone replacement therapy on breast cancer risk : Estrogen versus estrogen plus progestin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T14%3A42%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Hormone%20replacement%20therapy%20on%20breast%20cancer%20risk%20:%20Estrogen%20versus%20estrogen%20plus%20progestin&rft.jtitle=JNCI%20:%20Journal%20of%20the%20National%20Cancer%20Institute&rft.au=ROSS,%20R.%20K&rft.date=2000-02-16&rft.volume=92&rft.issue=4&rft.spage=328&rft.epage=332&rft.pages=328-332&rft.issn=0027-8874&rft.eissn=1460-2105&rft.coden=JNCIEQ&rft_id=info:doi/10.1093/jnci/92.4.328&rft_dat=%3Cproquest_cross%3E49960667%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220976987&rft_id=info:pmid/10675382&rfr_iscdi=true |