Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation

Δ 9 -Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of Δ 9 -tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant g...

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Veröffentlicht in:	Nature medicine 2000-03, Vol.6 (3), p.313-319
Hauptverfasser:	Guzmán, Manuel, Galve-Roperh, Ismael, Sánchez, Cristina, Cortés, María Luisa, del Pulgar, Teresa Gómez, Izquierdo, Marta
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Apoptosis Benzoxazines Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cancer Research Cannabinoids - therapeutic use Cannabinoids - toxicity Ceramides - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dronabinol - therapeutic use Dronabinol - toxicity Drug dosages extracellular signal-regulated kinase Glioma - drug therapy Glioma - metabolism Glioma - pathology Infectious Diseases JNK Mitogen-Activated Protein Kinases Kinases Ligands Magnetic resonance imaging Male Metabolic Diseases Mice Mice, Knockout Mitogen-Activated Protein Kinases - metabolism Molecular biology Molecular Medicine Morpholines - therapeutic use Morpholines - toxicity Naphthalenes - therapeutic use Naphthalenes - toxicity Neurosciences p38 Mitogen-Activated Protein Kinases RAG2 gene Rats Rats, Wistar Sphingomyelins - metabolism Sphingosine - analogs & derivatives Sphingosine - pharmacology Tetrahydrocannabinol THC Tumor Cells, Cultured Tumors
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