Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
Δ 9 -Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of Δ 9 -tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant g...
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| Veröffentlicht in: | Nature medicine 2000-03, Vol.6 (3), p.313-319 |
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| creator | Guzmán, Manuel Galve-Roperh, Ismael Sánchez, Cristina Cortés, María Luisa del Pulgar, Teresa Gómez Izquierdo, Marta |
| description | Δ
9
-Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of Δ
9
-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Cannabinoid treatment did not produce any substantial neurotoxic effect in the conditions used. Experiments with two subclones of C6 glioma cells in culture showed that cannabinoids signal apoptosis by a pathway involving cannabinoid receptors, sustained ceramide accumulation and Raf1/extracellular signal-regulated kinase activation. These results may provide the basis for a new therapeutic approach for the treatment of malignant gliomas. |
| doi_str_mv | 10.1038/73171 |
| format | Article |
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9
-Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of Δ
9
-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Cannabinoid treatment did not produce any substantial neurotoxic effect in the conditions used. Experiments with two subclones of C6 glioma cells in culture showed that cannabinoids signal apoptosis by a pathway involving cannabinoid receptors, sustained ceramide accumulation and Raf1/extracellular signal-regulated kinase activation. These results may provide the basis for a new therapeutic approach for the treatment of malignant gliomas.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/73171</identifier><identifier>PMID: 10700234</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Accumulation ; Animals ; Antineoplastic Agents - therapeutic use ; Antineoplastic Agents - toxicity ; Apoptosis ; Benzoxazines ; Biomedical and Life Sciences ; Biomedicine ; Brain cancer ; Brain Neoplasms - drug therapy ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Calcium-Calmodulin-Dependent Protein Kinases - metabolism ; Cancer Research ; Cannabinoids - therapeutic use ; Cannabinoids - toxicity ; Ceramides - metabolism ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Dronabinol - therapeutic use ; Dronabinol - toxicity ; Drug dosages ; extracellular signal-regulated kinase ; Glioma - drug therapy ; Glioma - metabolism ; Glioma - pathology ; Infectious Diseases ; JNK Mitogen-Activated Protein Kinases ; Kinases ; Ligands ; Magnetic resonance imaging ; Male ; Metabolic Diseases ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinases - metabolism ; Molecular biology ; Molecular Medicine ; Morpholines - therapeutic use ; Morpholines - toxicity ; Naphthalenes - therapeutic use ; Naphthalenes - toxicity ; Neurosciences ; p38 Mitogen-Activated Protein Kinases ; RAG2 gene ; Rats ; Rats, Wistar ; Sphingomyelins - metabolism ; Sphingosine - analogs & derivatives ; Sphingosine - pharmacology ; Tetrahydrocannabinol ; THC ; Tumor Cells, Cultured ; Tumors</subject><ispartof>Nature medicine, 2000-03, Vol.6 (3), p.313-319</ispartof><rights>Nature America Inc. 2000</rights><rights>COPYRIGHT 2000 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c631t-77d83fa15594444d8806fb4f85a62071543d85827adf7613bd1f0a6be7ddc7693</citedby><cites>FETCH-LOGICAL-c631t-77d83fa15594444d8806fb4f85a62071543d85827adf7613bd1f0a6be7ddc7693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/73171$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/73171$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10700234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guzmán, Manuel</creatorcontrib><creatorcontrib>Galve-Roperh, Ismael</creatorcontrib><creatorcontrib>Sánchez, Cristina</creatorcontrib><creatorcontrib>Cortés, María Luisa</creatorcontrib><creatorcontrib>del Pulgar, Teresa Gómez</creatorcontrib><creatorcontrib>Izquierdo, Marta</creatorcontrib><title>Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Δ
9
-Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of Δ
9
-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Cannabinoid treatment did not produce any substantial neurotoxic effect in the conditions used. Experiments with two subclones of C6 glioma cells in culture showed that cannabinoids signal apoptosis by a pathway involving cannabinoid receptors, sustained ceramide accumulation and Raf1/extracellular signal-regulated kinase activation. These results may provide the basis for a new therapeutic approach for the treatment of malignant gliomas.</description><subject>Accumulation</subject><subject>Animals</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Apoptosis</subject><subject>Benzoxazines</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases - metabolism</subject><subject>Cancer Research</subject><subject>Cannabinoids - therapeutic use</subject><subject>Cannabinoids - toxicity</subject><subject>Ceramides - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Dronabinol - therapeutic use</subject><subject>Dronabinol - toxicity</subject><subject>Drug dosages</subject><subject>extracellular signal-regulated kinase</subject><subject>Glioma - drug therapy</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Infectious Diseases</subject><subject>JNK Mitogen-Activated Protein Kinases</subject><subject>Kinases</subject><subject>Ligands</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Molecular biology</subject><subject>Molecular Medicine</subject><subject>Morpholines - therapeutic use</subject><subject>Morpholines - toxicity</subject><subject>Naphthalenes - therapeutic use</subject><subject>Naphthalenes - toxicity</subject><subject>Neurosciences</subject><subject>p38 Mitogen-Activated Protein Kinases</subject><subject>RAG2 gene</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sphingomyelins - metabolism</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Sphingosine - pharmacology</subject><subject>Tetrahydrocannabinol</subject><subject>THC</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkttu1DAQhiMEoqX0FVCERCUuUuw4jhPuVhWHlSpV4iTuotl4kro4dvFhBW_AY-NsKtqteoF9YWvm-2c848myY0pOKWHNG8GooI-yQ8qruqCCfH-c7kQ0RdPy-iB75v0VIYQR3j7NDpKDkJJVh9mflQmqCHGyDnQOfVDW5HbIezAGNspYJf3bfG22Vm9xQhNmp48-gDIo8x4dTEpiUvZxihp2ejAyx1_BQY9aJ6PLvRoN6MLhODNJ-EMZ8LhLuN2JnmdPBtAej2_Oo-zr-3dfzj4W5xcf1mer86KvGQ2FELJhA1DO2yot2TSkHjbV0HCoSyJS9Uw2vCkFyEHUlG0kHQjUGxRS9qJu2VF2ssS9dvZnRB-6Sfn5nWDQRt9RwZu6pmUCX94Dr2x0qQrflSWjZckrkaBigUbQ2Ckz2LnqEU3qi7YGB5XMK9pWJWkJ54k_fYBPW-Kk-gcFr_cEiQmptSNE77v150__z15822dP7rCXCDpceqvj_BV-H3y1gL2z3jscumunJnC_O0q6efK63eQl7sVNu-JmQnmHWkbtNqNPLjOiu-3n_Uj5AhoI0eG_SGZK40s6Rhn7Cxkk6Cw</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>Guzmán, 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action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation</title><author>Guzmán, Manuel ; Galve-Roperh, Ismael ; Sánchez, Cristina ; Cortés, María Luisa ; del Pulgar, Teresa Gómez ; Izquierdo, Marta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c631t-77d83fa15594444d8806fb4f85a62071543d85827adf7613bd1f0a6be7ddc7693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Accumulation</topic><topic>Animals</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Apoptosis</topic><topic>Benzoxazines</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain cancer</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - 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Medicine</topic><topic>Morpholines - therapeutic use</topic><topic>Morpholines - toxicity</topic><topic>Naphthalenes - therapeutic use</topic><topic>Naphthalenes - toxicity</topic><topic>Neurosciences</topic><topic>p38 Mitogen-Activated Protein Kinases</topic><topic>RAG2 gene</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sphingomyelins - metabolism</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Sphingosine - pharmacology</topic><topic>Tetrahydrocannabinol</topic><topic>THC</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guzmán, Manuel</creatorcontrib><creatorcontrib>Galve-Roperh, Ismael</creatorcontrib><creatorcontrib>Sánchez, Cristina</creatorcontrib><creatorcontrib>Cortés, María Luisa</creatorcontrib><creatorcontrib>del Pulgar, Teresa Gómez</creatorcontrib><creatorcontrib>Izquierdo, 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Marta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>6</volume><issue>3</issue><spage>313</spage><epage>319</epage><pages>313-319</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Δ
9
-Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of Δ
9
-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Cannabinoid treatment did not produce any substantial neurotoxic effect in the conditions used. Experiments with two subclones of C6 glioma cells in culture showed that cannabinoids signal apoptosis by a pathway involving cannabinoid receptors, sustained ceramide accumulation and Raf1/extracellular signal-regulated kinase activation. These results may provide the basis for a new therapeutic approach for the treatment of malignant gliomas.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>10700234</pmid><doi>10.1038/73171</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-8956 |
| ispartof | Nature medicine, 2000-03, Vol.6 (3), p.313-319 |
| issn | 1078-8956 1546-170X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Accumulation Animals Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Apoptosis Benzoxazines Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cancer Research Cannabinoids - therapeutic use Cannabinoids - toxicity Ceramides - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dronabinol - therapeutic use Dronabinol - toxicity Drug dosages extracellular signal-regulated kinase Glioma - drug therapy Glioma - metabolism Glioma - pathology Infectious Diseases JNK Mitogen-Activated Protein Kinases Kinases Ligands Magnetic resonance imaging Male Metabolic Diseases Mice Mice, Knockout Mitogen-Activated Protein Kinases - metabolism Molecular biology Molecular Medicine Morpholines - therapeutic use Morpholines - toxicity Naphthalenes - therapeutic use Naphthalenes - toxicity Neurosciences p38 Mitogen-Activated Protein Kinases RAG2 gene Rats Rats, Wistar Sphingomyelins - metabolism Sphingosine - analogs & derivatives Sphingosine - pharmacology Tetrahydrocannabinol THC Tumor Cells, Cultured Tumors |
| title | Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation |
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