Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra
Dopamine (DA) autooxidation, and consequent formation of neurotoxic DA-derived quinones and reactive oxygen species, has been implicated in dopaminergic cell death and, hence, in the pathogenesis of Parkinson’s disease (PD). Stimulation of pathways involved in the detoxication of DA-quinones in the...
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| creator | van Muiswinkel, F.L de Vos, R.A.I Bol, J.G.J.M Andringa, G Jansen Steur, E.N.H Ross, D Siegel, D Drukarch, B |
| description | Dopamine (DA) autooxidation, and consequent formation of neurotoxic DA-derived quinones and reactive oxygen species, has been implicated in dopaminergic cell death and, hence, in the pathogenesis of Parkinson’s disease (PD). Stimulation of pathways involved in the detoxication of DA-quinones in the brain is hypothesized to be an effective means to limit oxidative stress and to confer neuroprotection in PD. In this respect, the inducible flavoprotein NAD(P)H:quinone oxidoreductase (NQO1) is of particular interest as it is directly implicated in the detoxication of DA-quinones and, in addition, has broad spectrum anti-oxidant properties. To study the potential pathophysiological role of NQO1 in PD, the cellular expression of NQO1 was examined in the mesencephalon of PD patients and age-matched controls. In the substantia nigra
pars compacta (SNpc), NQO1 was found to be expressed in astroglial and endothelial cells and, albeit less frequently, also in dopaminergic neurons. Moreover, while overt NQO1 immunoreactivity was absent in the surrounding nervous tissue, in the Parkinsonian SNpc a marked increase in the astroglial and neuronal expression of NQO1 was consistently observed. |
| doi_str_mv | 10.1016/j.neurobiolaging.2003.12.010 |
| format | Article |
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pars compacta (SNpc), NQO1 was found to be expressed in astroglial and endothelial cells and, albeit less frequently, also in dopaminergic neurons. Moreover, while overt NQO1 immunoreactivity was absent in the surrounding nervous tissue, in the Parkinsonian SNpc a marked increase in the astroglial and neuronal expression of NQO1 was consistently observed.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2003.12.010</identifier><identifier>PMID: 15312971</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Astrocytes ; Astrocytes - enzymology ; Astrocytes - pathology ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dopamine - metabolism ; Dopaminergic neurons ; Endothelium, Vascular - enzymology ; Endothelium, Vascular - pathology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; NAD(P)H Dehydrogenase (Quinone) - metabolism ; NAD(P)H:quinone oxidoreductase ; Neurology ; Neurons - enzymology ; Neurons - pathology ; Neuropathology ; Oxidative Stress - physiology ; Parkinson Disease - enzymology ; Parkinson Disease - pathology ; Parkinson Disease - physiopathology ; Parkinson’s disease ; Reactive Oxygen Species - metabolism ; Substantia nigra ; Substantia Nigra - enzymology ; Substantia Nigra - pathology ; Substantia Nigra - physiopathology</subject><ispartof>Neurobiology of aging, 2004-10, Vol.25 (9), p.1253-1262</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-53c7d27382a27c3fb389e1eaa9e4692de4ab066347765840d06b84c08bc7b673</citedby><cites>FETCH-LOGICAL-c443t-53c7d27382a27c3fb389e1eaa9e4692de4ab066347765840d06b84c08bc7b673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197458004000399$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16023901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15312971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Muiswinkel, F.L</creatorcontrib><creatorcontrib>de Vos, R.A.I</creatorcontrib><creatorcontrib>Bol, J.G.J.M</creatorcontrib><creatorcontrib>Andringa, G</creatorcontrib><creatorcontrib>Jansen Steur, E.N.H</creatorcontrib><creatorcontrib>Ross, D</creatorcontrib><creatorcontrib>Siegel, D</creatorcontrib><creatorcontrib>Drukarch, B</creatorcontrib><title>Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Dopamine (DA) autooxidation, and consequent formation of neurotoxic DA-derived quinones and reactive oxygen species, has been implicated in dopaminergic cell death and, hence, in the pathogenesis of Parkinson’s disease (PD). Stimulation of pathways involved in the detoxication of DA-quinones in the brain is hypothesized to be an effective means to limit oxidative stress and to confer neuroprotection in PD. In this respect, the inducible flavoprotein NAD(P)H:quinone oxidoreductase (NQO1) is of particular interest as it is directly implicated in the detoxication of DA-quinones and, in addition, has broad spectrum anti-oxidant properties. To study the potential pathophysiological role of NQO1 in PD, the cellular expression of NQO1 was examined in the mesencephalon of PD patients and age-matched controls. In the substantia nigra
pars compacta (SNpc), NQO1 was found to be expressed in astroglial and endothelial cells and, albeit less frequently, also in dopaminergic neurons. Moreover, while overt NQO1 immunoreactivity was absent in the surrounding nervous tissue, in the Parkinsonian SNpc a marked increase in the astroglial and neuronal expression of NQO1 was consistently observed.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Astrocytes</subject><subject>Astrocytes - enzymology</subject><subject>Astrocytes - pathology</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dopamine - metabolism</subject><subject>Dopaminergic neurons</subject><subject>Endothelium, Vascular - enzymology</subject><subject>Endothelium, Vascular - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>NAD(P)H Dehydrogenase (Quinone) - metabolism</subject><subject>NAD(P)H:quinone oxidoreductase</subject><subject>Neurology</subject><subject>Neurons - enzymology</subject><subject>Neurons - pathology</subject><subject>Neuropathology</subject><subject>Oxidative Stress - physiology</subject><subject>Parkinson Disease - enzymology</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson’s disease</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Substantia nigra</subject><subject>Substantia Nigra - enzymology</subject><subject>Substantia Nigra - pathology</subject><subject>Substantia Nigra - physiopathology</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0E1v1DAQgGELgehS-AvIB0BwSPBX7KTiUpWWIlXQQ49I1sSeLF6y9tZOUPn3ZLUrVdw4zeUZe_QS8oazmjOuP27qiHNOfUgjrENc14IxWXNRM86ekBVvmrbiqjNPyYrxzlSqadkJeVHKhjFmlNHPyQlvJBed4Svy4_Jhl7GUkCJNA_12_vn97Yfrs_s5xBSRpofgU0Y_uwkK0hDp9BNpTHkLI4Xo6S3kXyGWFANEWua-TBCnADSGdYaX5NkAY8FXx3lK7q4u7y6uq5vvX75enN9UTik5VY10xgsjWwHCODn0su2QI0CHSnfCo4KeaS2VMbppFfNM961yrO2d6bWRp-Td4dldTvczlsluQ3E4jhAxzcVy07RadXyBnw7Q5VRKxsHucthC_mM5s_u4dmP_jWv3cS0Xdom7rL8-_jP3W_SPy8eaC3h7BFAcjEOG6EJ5dJoJ2bG9uzo4XKL8DphtcQGjQx8yusn6FP7vor8i4qEC</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>van Muiswinkel, F.L</creator><creator>de Vos, R.A.I</creator><creator>Bol, J.G.J.M</creator><creator>Andringa, G</creator><creator>Jansen Steur, E.N.H</creator><creator>Ross, D</creator><creator>Siegel, D</creator><creator>Drukarch, B</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20041001</creationdate><title>Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra</title><author>van Muiswinkel, F.L ; de Vos, R.A.I ; Bol, J.G.J.M ; Andringa, G ; Jansen Steur, E.N.H ; Ross, D ; Siegel, D ; Drukarch, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-53c7d27382a27c3fb389e1eaa9e4692de4ab066347765840d06b84c08bc7b673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Astrocytes</topic><topic>Astrocytes - enzymology</topic><topic>Astrocytes - pathology</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dopamine - metabolism</topic><topic>Dopaminergic neurons</topic><topic>Endothelium, Vascular - enzymology</topic><topic>Endothelium, Vascular - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>NAD(P)H Dehydrogenase (Quinone) - metabolism</topic><topic>NAD(P)H:quinone oxidoreductase</topic><topic>Neurology</topic><topic>Neurons - enzymology</topic><topic>Neurons - pathology</topic><topic>Neuropathology</topic><topic>Oxidative Stress - physiology</topic><topic>Parkinson Disease - enzymology</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson’s disease</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Substantia nigra</topic><topic>Substantia Nigra - enzymology</topic><topic>Substantia Nigra - pathology</topic><topic>Substantia Nigra - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Muiswinkel, F.L</creatorcontrib><creatorcontrib>de Vos, R.A.I</creatorcontrib><creatorcontrib>Bol, J.G.J.M</creatorcontrib><creatorcontrib>Andringa, G</creatorcontrib><creatorcontrib>Jansen Steur, E.N.H</creatorcontrib><creatorcontrib>Ross, D</creatorcontrib><creatorcontrib>Siegel, D</creatorcontrib><creatorcontrib>Drukarch, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Muiswinkel, F.L</au><au>de Vos, R.A.I</au><au>Bol, J.G.J.M</au><au>Andringa, G</au><au>Jansen Steur, E.N.H</au><au>Ross, D</au><au>Siegel, D</au><au>Drukarch, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>25</volume><issue>9</issue><spage>1253</spage><epage>1262</epage><pages>1253-1262</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Dopamine (DA) autooxidation, and consequent formation of neurotoxic DA-derived quinones and reactive oxygen species, has been implicated in dopaminergic cell death and, hence, in the pathogenesis of Parkinson’s disease (PD). Stimulation of pathways involved in the detoxication of DA-quinones in the brain is hypothesized to be an effective means to limit oxidative stress and to confer neuroprotection in PD. In this respect, the inducible flavoprotein NAD(P)H:quinone oxidoreductase (NQO1) is of particular interest as it is directly implicated in the detoxication of DA-quinones and, in addition, has broad spectrum anti-oxidant properties. To study the potential pathophysiological role of NQO1 in PD, the cellular expression of NQO1 was examined in the mesencephalon of PD patients and age-matched controls. In the substantia nigra
pars compacta (SNpc), NQO1 was found to be expressed in astroglial and endothelial cells and, albeit less frequently, also in dopaminergic neurons. Moreover, while overt NQO1 immunoreactivity was absent in the surrounding nervous tissue, in the Parkinsonian SNpc a marked increase in the astroglial and neuronal expression of NQO1 was consistently observed.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>15312971</pmid><doi>10.1016/j.neurobiolaging.2003.12.010</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Astrocytes Astrocytes - enzymology Astrocytes - pathology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - metabolism Dopaminergic neurons Endothelium, Vascular - enzymology Endothelium, Vascular - pathology Female Humans Male Medical sciences Middle Aged NAD(P)H Dehydrogenase (Quinone) - metabolism NAD(P)H:quinone oxidoreductase Neurology Neurons - enzymology Neurons - pathology Neuropathology Oxidative Stress - physiology Parkinson Disease - enzymology Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson’s disease Reactive Oxygen Species - metabolism Substantia nigra Substantia Nigra - enzymology Substantia Nigra - pathology Substantia Nigra - physiopathology |
| title | Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra |
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