8-Substituted, syn-Configured Adenosine Derivatives as Potential Inhibitors of the Enzyme IspE from the Non-Mevalonate Pathway of Isoprenoid Biosynthesis

The enzymes of the non‐mevalonate pathway for isoprenoid biosynthesis are attractive targets for drugs against various diseases, including malaria. We describe herein the structure‐based design, synthesis, conformational analysis, and biological evaluation of several 8‐brominated or 8‐aminated adeno...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of organic chemistry 2015-11, Vol.2015 (33), p.7276-7286
Hauptverfasser:	Harder, Michael, Schäfer, Elisabeth, Kümin, Tobias, Illarionov, Boris, Bacher, Adelbert, Fischer, Markus, Diederich, François, Bernet, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Binding sites Biosynthesis Conformation analysis Enzymes Hydrogen bonds Inhibitors Medicinal chemistry Nucleosides
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!