Paraoxonase 1 polymorphisms and haplotypes and the risk for having offspring affected with spina bifida in Southeast Mexico

BACKGROUND Spina bifida (SB) is a common congenital malformation in Southeast Mexico. Parents of children with SB reside in areas with frequent pesticide spraying or have agriculture activities, suggesting potential exposure to pesticides. Paraoxonase 1 (PON1) is the responsible enzyme for deactivat...

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Veröffentlicht in:	Birth defects research. A Clinical and molecular teratology 2010-11, Vol.88 (11), p.987-994
Hauptverfasser:	Gonzalez-Herrera, Lizbeth, Martín Cerda-Flores, Ricardo, Luna-Rivero, Marianne, Canto-Herrera, Jorge, Pinto-Escalante, Doris, Perez-Herrera, Norma, Quintanilla-Vega, Betzabet
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aryldialkylphosphatase - genetics Aryldialkylphosphatase - metabolism Case-Control Studies Child Female Gene Frequency Genotype Haplotypes Heterozygote Homozygote Humans Male Mexico - epidemiology Middle Aged neural tube defects Odds Ratio Organophosphates - toxicity paraoxonase 1 paraoxonase 1, PON1 polymorphisms Pesticides - toxicity Polymerase Chain Reaction Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length PON1 polymorphisms Risk Factors spina bifida Spinal Dysraphism - epidemiology Spinal Dysraphism - genetics Young Adult Yucatán
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