New bone formation in a true bone ceramic scaffold loaded with desferrioxamine in the treatment of segmental bone defect: a preliminary study

Desferrioxamine (DFO), an iron chelator, can stimulate osteogenesis and angiogenesis by stabilizing hypoxia-inducible factor 1α. We postulate that a bone graft substitute combined with DFO is beneficial to the reconstruction of bone defects. We implanted pure true bone ceramic (TBC) and DFO-loaded T...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2012-05, Vol.17 (3), p.289-298
Hauptverfasser:	Zhang, Weibin, Li, Guosong, Deng, Lianfu, Qiu, Shijing, Deng, Ruoxian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone and Bones - surgery Ceramics Deferoxamine - pharmacology Medicine Medicine & Public Health Original Article Orthopedics Osteogenesis - drug effects Rabbits Rheumatology Siderophores - pharmacology Tissue Scaffolds
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!