New bone formation in a true bone ceramic scaffold loaded with desferrioxamine in the treatment of segmental bone defect: a preliminary study
Desferrioxamine (DFO), an iron chelator, can stimulate osteogenesis and angiogenesis by stabilizing hypoxia-inducible factor 1α. We postulate that a bone graft substitute combined with DFO is beneficial to the reconstruction of bone defects. We implanted pure true bone ceramic (TBC) and DFO-loaded T...
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| Veröffentlicht in: | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2012-05, Vol.17 (3), p.289-298 |
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| container_title | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association |
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| creator | Zhang, Weibin Li, Guosong Deng, Lianfu Qiu, Shijing Deng, Ruoxian |
| description | Desferrioxamine (DFO), an iron chelator, can stimulate osteogenesis and angiogenesis by stabilizing hypoxia-inducible factor 1α. We postulate that a bone graft substitute combined with DFO is beneficial to the reconstruction of bone defects.
We implanted pure true bone ceramic (TBC) and DFO-loaded TBC (DFO/TBC) scaffolds into 15-mm rabbit radial defects for 8weeks. The bone segments were examined with X-ray, micro-CT and histology.
Radiographs showed that the DFO/TBC scaffold became radiopaque, and the gaps between the scaffold and radial cut ends were often invisible. Variables from micro-CT, including the bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and trabecular number (Tb.N), were significantly increased in pure TBC and DFO/TBC scaffolds that had been implanted for 8weeks compared to unimplanted TBC scaffolds (p values |
| doi_str_mv | 10.1007/s00776-012-0206-z |
| format | Article |
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We implanted pure true bone ceramic (TBC) and DFO-loaded TBC (DFO/TBC) scaffolds into 15-mm rabbit radial defects for 8weeks. The bone segments were examined with X-ray, micro-CT and histology.
Radiographs showed that the DFO/TBC scaffold became radiopaque, and the gaps between the scaffold and radial cut ends were often invisible. Variables from micro-CT, including the bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and trabecular number (Tb.N), were significantly increased in pure TBC and DFO/TBC scaffolds that had been implanted for 8weeks compared to unimplanted TBC scaffolds (p values <0.05–0.001). Between the former two groups, BV/TV and Tb.Th were significantly increased in DFO/TBC scaffolds (p < 0.001), but Tb.N did not show significant differences. Histological examinations showed considerably increased new bone and decreased TBC trabecular remnants in DFO/TBC scaffolds compared to pure TBC scaffolds. Many cavities in the new bone area in DFO/TBC scaffolds were occupied by bone marrow elements and blood vessels. Percent of new bone with tetracycline labeling was significantly greater in DFO/TBC scaffolds than in pure TBC scaffolds (p < 0.001).
This preliminary study reveals that DFO can effectively induce new bone growing into TBC scaffolds, suggesting that the DFO/TBC composite is a promising bone graft substitute for the treatment of bone defects.</description><identifier>ISSN: 0949-2658</identifier><identifier>ISSN: 1436-2023</identifier><identifier>EISSN: 1436-2023</identifier><identifier>DOI: 10.1007/s00776-012-0206-z</identifier><identifier>PMID: 22526711</identifier><language>eng</language><publisher>Japan: Elsevier B.V</publisher><subject>Animals ; Bone and Bones - surgery ; Ceramics ; Deferoxamine - pharmacology ; Medicine ; Medicine & Public Health ; Original Article ; Orthopedics ; Osteogenesis - drug effects ; Rabbits ; Rheumatology ; Siderophores - pharmacology ; Tissue Scaffolds</subject><ispartof>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2012-05, Vol.17 (3), p.289-298</ispartof><rights>2012 The Japanese Orthopaedic Association</rights><rights>The Japanese Orthopaedic Association 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-7e5d8e9c6ccaba6f55cf4c34dc50eb5eb544f96cece4ebc57dbff2cb0a0f94c43</citedby><cites>FETCH-LOGICAL-c481t-7e5d8e9c6ccaba6f55cf4c34dc50eb5eb544f96cece4ebc57dbff2cb0a0f94c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00776-012-0206-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00776-012-0206-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22526711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Weibin</creatorcontrib><creatorcontrib>Li, Guosong</creatorcontrib><creatorcontrib>Deng, Lianfu</creatorcontrib><creatorcontrib>Qiu, Shijing</creatorcontrib><creatorcontrib>Deng, Ruoxian</creatorcontrib><title>New bone formation in a true bone ceramic scaffold loaded with desferrioxamine in the treatment of segmental bone defect: a preliminary study</title><title>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</title><addtitle>J Orthop Sci</addtitle><addtitle>J Orthop Sci</addtitle><description>Desferrioxamine (DFO), an iron chelator, can stimulate osteogenesis and angiogenesis by stabilizing hypoxia-inducible factor 1α. We postulate that a bone graft substitute combined with DFO is beneficial to the reconstruction of bone defects.
We implanted pure true bone ceramic (TBC) and DFO-loaded TBC (DFO/TBC) scaffolds into 15-mm rabbit radial defects for 8weeks. The bone segments were examined with X-ray, micro-CT and histology.
Radiographs showed that the DFO/TBC scaffold became radiopaque, and the gaps between the scaffold and radial cut ends were often invisible. Variables from micro-CT, including the bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and trabecular number (Tb.N), were significantly increased in pure TBC and DFO/TBC scaffolds that had been implanted for 8weeks compared to unimplanted TBC scaffolds (p values <0.05–0.001). Between the former two groups, BV/TV and Tb.Th were significantly increased in DFO/TBC scaffolds (p < 0.001), but Tb.N did not show significant differences. Histological examinations showed considerably increased new bone and decreased TBC trabecular remnants in DFO/TBC scaffolds compared to pure TBC scaffolds. Many cavities in the new bone area in DFO/TBC scaffolds were occupied by bone marrow elements and blood vessels. Percent of new bone with tetracycline labeling was significantly greater in DFO/TBC scaffolds than in pure TBC scaffolds (p < 0.001).
This preliminary study reveals that DFO can effectively induce new bone growing into TBC scaffolds, suggesting that the DFO/TBC composite is a promising bone graft substitute for the treatment of bone defects.</description><subject>Animals</subject><subject>Bone and Bones - surgery</subject><subject>Ceramics</subject><subject>Deferoxamine - pharmacology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteogenesis - drug effects</subject><subject>Rabbits</subject><subject>Rheumatology</subject><subject>Siderophores - pharmacology</subject><subject>Tissue Scaffolds</subject><issn>0949-2658</issn><issn>1436-2023</issn><issn>1436-2023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1qFjEUhoMo9rN6AW4k4MbNaJLJz4yupPgHRTe6HjLJSZsyM_lMMtb2Hrxnz-dUEUGFkATyPOeQ8xLykLOnnDHzrOBmdMO4aJhgurm-RXZctroRTLS3yY71sm-EVt0RuVfKBWPcqF7dJUdCKKEN5zvy7T1c0jEtQEPKs60xLTQu1NKaV9geHGQ7R0eLsyGkydMpWQ-eXsZ6Tj2UADnH9BUZhNGt54A22DrDUmkKtMDZ4WqnrZ6HAK4-xx77DFNEzeYrWurqr-6TO8FOBR7cnMfk0-tXH0_eNqcf3rw7eXnaONnx2hhQvoPeaefsaHVQygXpWumdYjAqXFKGXjtwIGF0yvgxBOFGZlnopZPtMXmy1d3n9HmFUoc5FgfTZBdIaxlwTp2QbSfU_1HGtTZCKobo4z_Qi7TmBT_yg2JGGWOQ4hvlciolQxj2Oc44AoSGQ6zDFuuAsQ6HWIdrdB7dVF7HGfwv42eOCIgNKPi0nEH-vfXfq77YJMBRf4koFRdhceBjxoQGn-I_7O-P-MRW</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Zhang, Weibin</creator><creator>Li, Guosong</creator><creator>Deng, Lianfu</creator><creator>Qiu, Shijing</creator><creator>Deng, Ruoxian</creator><general>Elsevier B.V</general><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20120501</creationdate><title>New bone formation in a true bone ceramic scaffold loaded with desferrioxamine in the treatment of segmental bone defect: a preliminary study</title><author>Zhang, Weibin ; Li, Guosong ; Deng, Lianfu ; Qiu, Shijing ; Deng, Ruoxian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-7e5d8e9c6ccaba6f55cf4c34dc50eb5eb544f96cece4ebc57dbff2cb0a0f94c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Bone and Bones - surgery</topic><topic>Ceramics</topic><topic>Deferoxamine - pharmacology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteogenesis - drug effects</topic><topic>Rabbits</topic><topic>Rheumatology</topic><topic>Siderophores - pharmacology</topic><topic>Tissue Scaffolds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Weibin</creatorcontrib><creatorcontrib>Li, Guosong</creatorcontrib><creatorcontrib>Deng, Lianfu</creatorcontrib><creatorcontrib>Qiu, Shijing</creatorcontrib><creatorcontrib>Deng, Ruoxian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Weibin</au><au>Li, Guosong</au><au>Deng, Lianfu</au><au>Qiu, Shijing</au><au>Deng, Ruoxian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New bone formation in a true bone ceramic scaffold loaded with desferrioxamine in the treatment of segmental bone defect: a preliminary study</atitle><jtitle>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</jtitle><stitle>J Orthop Sci</stitle><addtitle>J Orthop Sci</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>17</volume><issue>3</issue><spage>289</spage><epage>298</epage><pages>289-298</pages><issn>0949-2658</issn><issn>1436-2023</issn><eissn>1436-2023</eissn><abstract>Desferrioxamine (DFO), an iron chelator, can stimulate osteogenesis and angiogenesis by stabilizing hypoxia-inducible factor 1α. We postulate that a bone graft substitute combined with DFO is beneficial to the reconstruction of bone defects.
We implanted pure true bone ceramic (TBC) and DFO-loaded TBC (DFO/TBC) scaffolds into 15-mm rabbit radial defects for 8weeks. The bone segments were examined with X-ray, micro-CT and histology.
Radiographs showed that the DFO/TBC scaffold became radiopaque, and the gaps between the scaffold and radial cut ends were often invisible. Variables from micro-CT, including the bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and trabecular number (Tb.N), were significantly increased in pure TBC and DFO/TBC scaffolds that had been implanted for 8weeks compared to unimplanted TBC scaffolds (p values <0.05–0.001). Between the former two groups, BV/TV and Tb.Th were significantly increased in DFO/TBC scaffolds (p < 0.001), but Tb.N did not show significant differences. Histological examinations showed considerably increased new bone and decreased TBC trabecular remnants in DFO/TBC scaffolds compared to pure TBC scaffolds. Many cavities in the new bone area in DFO/TBC scaffolds were occupied by bone marrow elements and blood vessels. Percent of new bone with tetracycline labeling was significantly greater in DFO/TBC scaffolds than in pure TBC scaffolds (p < 0.001).
This preliminary study reveals that DFO can effectively induce new bone growing into TBC scaffolds, suggesting that the DFO/TBC composite is a promising bone graft substitute for the treatment of bone defects.</abstract><cop>Japan</cop><pub>Elsevier B.V</pub><pmid>22526711</pmid><doi>10.1007/s00776-012-0206-z</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Animals Bone and Bones - surgery Ceramics Deferoxamine - pharmacology Medicine Medicine & Public Health Original Article Orthopedics Osteogenesis - drug effects Rabbits Rheumatology Siderophores - pharmacology Tissue Scaffolds |
| title | New bone formation in a true bone ceramic scaffold loaded with desferrioxamine in the treatment of segmental bone defect: a preliminary study |
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