Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients
Treadmill exercise nitrogen-13 (13N)-ammonia positron emission tomography (PET) has logistical challenges and limited literature. We aimed to assess its feasibility, image quality, and diagnostic accuracy in obese and nonobese patients. Between 2009 and 2012, 10,804 patients were referred for myocar...
Gespeichert in:
| Veröffentlicht in: | Journal of nuclear cardiology 2015-12, Vol.22 (6), p.1273-1280 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1280 |
|---|---|
| container_issue | 6 |
| container_start_page | 1273 |
| container_title | Journal of nuclear cardiology |
| container_volume | 22 |
| creator | Aggarwal, Niti R. Drozdova, Adela Wells Askew, J. Kemp, Bradley J. Chareonthaitawee, Panithaya |
| description | Treadmill exercise nitrogen-13 (13N)-ammonia positron emission tomography (PET) has logistical challenges and limited literature. We aimed to assess its feasibility, image quality, and diagnostic accuracy in obese and nonobese patients.
Between 2009 and 2012, 10,804 patients were referred for myocardial perfusion imaging, including 300 for treadmill PET, of whom 265 were included in this study. Treadmill testing and PET were performed using standard procedures. Image quality, perfusion, and summed stress score (SSS) were assessed. Invasive coronary angiography was performed within 90 days of PET in 43 patients. Mean ± SD body mass index (BMI) was 35.7 ± 7.7 kg/m2 (range 19.5-63.5 kg/m2). Feasibility of treadmill 13N-ammonia PET was 100%. Exercise duration was less for obese patients than nonobese patients (P < .001). Image quality was rated good for 96.9% of obese and 100% of nonobese patients. For all patients, sensitivity was 86.4% and specificity was 74.4%. Diagnostic accuracy did not change significantly with increasing BMI. SSS remained significant in predicting angiographic coronary artery disease after adjustment for age, sex, and Duke treadmill score.
Treadmill 13N-ammonia PET is highly feasible, yields good image quality, and has moderately high diagnostic accuracy in a small subset of obese and nonobese patients who are deemed able to perform treadmill exercise. |
| doi_str_mv | 10.1007/s12350-015-0073-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1758242751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1071358123071866</els_id><sourcerecordid>1735329152</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-dc58d0ad781be834e92dd9e4b32274191ae6fa4408987fd942d3399673494ed33</originalsourceid><addsrcrecordid>eNqNkU9rFTEUxYMotlY_gBsJuHEzmr8vE1xJaVUo6KKuQya5M6TMJM8kI76u_OjmOVXERTGb3JDfOZd7D0LPKXlNCVFvCmVcko5Q2bUn724foFMqOet2UtKHrSaKdlz29AQ9KeWGEKK51o_RCZOqnZ6coh-XYEsYwhzqAdvosQ92iqnU4LB1bs3WHXAaMXyH7EIBXDNYv4R5xjHUnCaIHeXYLkuKweLPF9d4OSRnc_OZ8R7yuJaQIg6LnUKcjlZpgOaztzVArOUpejTaucCzu_sMfbm8uD7_0F19ev_x_N1V5yRTtfNO9p5Yr3o6QM8FaOa9BjFwxpSgmlrYjVYI0utejV4L5nmbdae40AJafYZebb77nL6uUKpZQnEwzzZCWouhSvZMMCXpf6C8LVlTyRr68h_0Jq05tkGOlNhRwX4Z0o1yOZWSYTT73BaSD4YSc0zSbEmalqQ5Jmlum-bFnfM6LOD_KH5H1wC2AaV9xQnyX63vcX27iaCt-ltoouJaDA58yOCq8Snco_4JCYe9Aw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1734614251</pqid></control><display><type>article</type><title>Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Aggarwal, Niti R. ; Drozdova, Adela ; Wells Askew, J. ; Kemp, Bradley J. ; Chareonthaitawee, Panithaya</creator><creatorcontrib>Aggarwal, Niti R. ; Drozdova, Adela ; Wells Askew, J. ; Kemp, Bradley J. ; Chareonthaitawee, Panithaya</creatorcontrib><description>Treadmill exercise nitrogen-13 (13N)-ammonia positron emission tomography (PET) has logistical challenges and limited literature. We aimed to assess its feasibility, image quality, and diagnostic accuracy in obese and nonobese patients.
Between 2009 and 2012, 10,804 patients were referred for myocardial perfusion imaging, including 300 for treadmill PET, of whom 265 were included in this study. Treadmill testing and PET were performed using standard procedures. Image quality, perfusion, and summed stress score (SSS) were assessed. Invasive coronary angiography was performed within 90 days of PET in 43 patients. Mean ± SD body mass index (BMI) was 35.7 ± 7.7 kg/m2 (range 19.5-63.5 kg/m2). Feasibility of treadmill 13N-ammonia PET was 100%. Exercise duration was less for obese patients than nonobese patients (P < .001). Image quality was rated good for 96.9% of obese and 100% of nonobese patients. For all patients, sensitivity was 86.4% and specificity was 74.4%. Diagnostic accuracy did not change significantly with increasing BMI. SSS remained significant in predicting angiographic coronary artery disease after adjustment for age, sex, and Duke treadmill score.
Treadmill 13N-ammonia PET is highly feasible, yields good image quality, and has moderately high diagnostic accuracy in a small subset of obese and nonobese patients who are deemed able to perform treadmill exercise.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1007/s12350-015-0073-z</identifier><identifier>PMID: 25777780</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Aged ; Ammonia ; Cardiology ; Coronary artery disease ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnostic imaging ; exercise stress testing ; Exercise Test ; Feasibility Studies ; Female ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; myocardial perfusion imaging ; Myocardial Perfusion Imaging - methods ; Nitrogen Radioisotopes ; Nuclear Medicine ; obesity ; Obesity - complications ; Obesity - diagnostic imaging ; Original Article ; positron emission tomography ; Positron-Emission Tomography - methods ; Radiology ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity</subject><ispartof>Journal of nuclear cardiology, 2015-12, Vol.22 (6), p.1273-1280</ispartof><rights>2015 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved.</rights><rights>American Society of Nuclear Cardiology 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-dc58d0ad781be834e92dd9e4b32274191ae6fa4408987fd942d3399673494ed33</citedby><cites>FETCH-LOGICAL-c527t-dc58d0ad781be834e92dd9e4b32274191ae6fa4408987fd942d3399673494ed33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12350-015-0073-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12350-015-0073-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25777780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aggarwal, Niti R.</creatorcontrib><creatorcontrib>Drozdova, Adela</creatorcontrib><creatorcontrib>Wells Askew, J.</creatorcontrib><creatorcontrib>Kemp, Bradley J.</creatorcontrib><creatorcontrib>Chareonthaitawee, Panithaya</creatorcontrib><title>Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients</title><title>Journal of nuclear cardiology</title><addtitle>J. Nucl. Cardiol</addtitle><addtitle>J Nucl Cardiol</addtitle><description>Treadmill exercise nitrogen-13 (13N)-ammonia positron emission tomography (PET) has logistical challenges and limited literature. We aimed to assess its feasibility, image quality, and diagnostic accuracy in obese and nonobese patients.
Between 2009 and 2012, 10,804 patients were referred for myocardial perfusion imaging, including 300 for treadmill PET, of whom 265 were included in this study. Treadmill testing and PET were performed using standard procedures. Image quality, perfusion, and summed stress score (SSS) were assessed. Invasive coronary angiography was performed within 90 days of PET in 43 patients. Mean ± SD body mass index (BMI) was 35.7 ± 7.7 kg/m2 (range 19.5-63.5 kg/m2). Feasibility of treadmill 13N-ammonia PET was 100%. Exercise duration was less for obese patients than nonobese patients (P < .001). Image quality was rated good for 96.9% of obese and 100% of nonobese patients. For all patients, sensitivity was 86.4% and specificity was 74.4%. Diagnostic accuracy did not change significantly with increasing BMI. SSS remained significant in predicting angiographic coronary artery disease after adjustment for age, sex, and Duke treadmill score.
Treadmill 13N-ammonia PET is highly feasible, yields good image quality, and has moderately high diagnostic accuracy in a small subset of obese and nonobese patients who are deemed able to perform treadmill exercise.</description><subject>Aged</subject><subject>Ammonia</subject><subject>Cardiology</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>exercise stress testing</subject><subject>Exercise Test</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>myocardial perfusion imaging</subject><subject>Myocardial Perfusion Imaging - methods</subject><subject>Nitrogen Radioisotopes</subject><subject>Nuclear Medicine</subject><subject>obesity</subject><subject>Obesity - complications</subject><subject>Obesity - diagnostic imaging</subject><subject>Original Article</subject><subject>positron emission tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radiology</subject><subject>Radiopharmaceuticals</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU9rFTEUxYMotlY_gBsJuHEzmr8vE1xJaVUo6KKuQya5M6TMJM8kI76u_OjmOVXERTGb3JDfOZd7D0LPKXlNCVFvCmVcko5Q2bUn724foFMqOet2UtKHrSaKdlz29AQ9KeWGEKK51o_RCZOqnZ6coh-XYEsYwhzqAdvosQ92iqnU4LB1bs3WHXAaMXyH7EIBXDNYv4R5xjHUnCaIHeXYLkuKweLPF9d4OSRnc_OZ8R7yuJaQIg6LnUKcjlZpgOaztzVArOUpejTaucCzu_sMfbm8uD7_0F19ev_x_N1V5yRTtfNO9p5Yr3o6QM8FaOa9BjFwxpSgmlrYjVYI0utejV4L5nmbdae40AJafYZebb77nL6uUKpZQnEwzzZCWouhSvZMMCXpf6C8LVlTyRr68h_0Jq05tkGOlNhRwX4Z0o1yOZWSYTT73BaSD4YSc0zSbEmalqQ5Jmlum-bFnfM6LOD_KH5H1wC2AaV9xQnyX63vcX27iaCt-ltoouJaDA58yOCq8Snco_4JCYe9Aw</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Aggarwal, Niti R.</creator><creator>Drozdova, Adela</creator><creator>Wells Askew, J.</creator><creator>Kemp, Bradley J.</creator><creator>Chareonthaitawee, Panithaya</creator><general>Elsevier Inc</general><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20151201</creationdate><title>Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients</title><author>Aggarwal, Niti R. ; Drozdova, Adela ; Wells Askew, J. ; Kemp, Bradley J. ; Chareonthaitawee, Panithaya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-dc58d0ad781be834e92dd9e4b32274191ae6fa4408987fd942d3399673494ed33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Ammonia</topic><topic>Cardiology</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>exercise stress testing</topic><topic>Exercise Test</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>myocardial perfusion imaging</topic><topic>Myocardial Perfusion Imaging - methods</topic><topic>Nitrogen Radioisotopes</topic><topic>Nuclear Medicine</topic><topic>obesity</topic><topic>Obesity - complications</topic><topic>Obesity - diagnostic imaging</topic><topic>Original Article</topic><topic>positron emission tomography</topic><topic>Positron-Emission Tomography - methods</topic><topic>Radiology</topic><topic>Radiopharmaceuticals</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aggarwal, Niti R.</creatorcontrib><creatorcontrib>Drozdova, Adela</creatorcontrib><creatorcontrib>Wells Askew, J.</creatorcontrib><creatorcontrib>Kemp, Bradley J.</creatorcontrib><creatorcontrib>Chareonthaitawee, Panithaya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aggarwal, Niti R.</au><au>Drozdova, Adela</au><au>Wells Askew, J.</au><au>Kemp, Bradley J.</au><au>Chareonthaitawee, Panithaya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients</atitle><jtitle>Journal of nuclear cardiology</jtitle><stitle>J. Nucl. Cardiol</stitle><addtitle>J Nucl Cardiol</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>22</volume><issue>6</issue><spage>1273</spage><epage>1280</epage><pages>1273-1280</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>Treadmill exercise nitrogen-13 (13N)-ammonia positron emission tomography (PET) has logistical challenges and limited literature. We aimed to assess its feasibility, image quality, and diagnostic accuracy in obese and nonobese patients.
Between 2009 and 2012, 10,804 patients were referred for myocardial perfusion imaging, including 300 for treadmill PET, of whom 265 were included in this study. Treadmill testing and PET were performed using standard procedures. Image quality, perfusion, and summed stress score (SSS) were assessed. Invasive coronary angiography was performed within 90 days of PET in 43 patients. Mean ± SD body mass index (BMI) was 35.7 ± 7.7 kg/m2 (range 19.5-63.5 kg/m2). Feasibility of treadmill 13N-ammonia PET was 100%. Exercise duration was less for obese patients than nonobese patients (P < .001). Image quality was rated good for 96.9% of obese and 100% of nonobese patients. For all patients, sensitivity was 86.4% and specificity was 74.4%. Diagnostic accuracy did not change significantly with increasing BMI. SSS remained significant in predicting angiographic coronary artery disease after adjustment for age, sex, and Duke treadmill score.
Treadmill 13N-ammonia PET is highly feasible, yields good image quality, and has moderately high diagnostic accuracy in a small subset of obese and nonobese patients who are deemed able to perform treadmill exercise.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>25777780</pmid><doi>10.1007/s12350-015-0073-z</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1071-3581 |
| ispartof | Journal of nuclear cardiology, 2015-12, Vol.22 (6), p.1273-1280 |
| issn | 1071-3581 1532-6551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1758242751 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Aged Ammonia Cardiology Coronary artery disease Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging exercise stress testing Exercise Test Feasibility Studies Female Humans Imaging Male Medicine Medicine & Public Health Middle Aged myocardial perfusion imaging Myocardial Perfusion Imaging - methods Nitrogen Radioisotopes Nuclear Medicine obesity Obesity - complications Obesity - diagnostic imaging Original Article positron emission tomography Positron-Emission Tomography - methods Radiology Radiopharmaceuticals Reproducibility of Results Sensitivity and Specificity |
| title | Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T14%3A02%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Feasibility%20and%20diagnostic%20accuracy%20of%20exercise%20treadmill%20nitrogen-13%20ammonia%20PET%20myocardial%20perfusion%20imaging%20of%20obese%20patients&rft.jtitle=Journal%20of%20nuclear%20cardiology&rft.au=Aggarwal,%20Niti%20R.&rft.date=2015-12-01&rft.volume=22&rft.issue=6&rft.spage=1273&rft.epage=1280&rft.pages=1273-1280&rft.issn=1071-3581&rft.eissn=1532-6551&rft_id=info:doi/10.1007/s12350-015-0073-z&rft_dat=%3Cproquest_cross%3E1735329152%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1734614251&rft_id=info:pmid/25777780&rft_els_id=S1071358123071866&rfr_iscdi=true |