Aquaporin-4 in manganese-treated cultured astrocytes

Manganese in excess is neurotoxic and causes CNS injury resembling that of Parkinson's disease. In brain, astrocytes predominantly take up and accumulate manganese and are thus vulnerable to its toxicity. Manganese was shown to induce cell swelling in cultured astrocytes, and oxidative/nitrosat...

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Veröffentlicht in:	Glia 2010-09, Vol.58 (12), p.1490-1499
Hauptverfasser:	Rama Rao, Kakulavarapu V., Jayakumar, Arumugam R., Reddy, Pichili V. B., Tong, Xiaoying, Curtis, Kevin M., Norenberg, M. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antioxidants - pharmacology Aquaporin 4 Aquaporin 4 - genetics Aquaporin 4 - metabolism astrocyte swelling Astrocytes Astrocytes - drug effects Biotinylation - methods c-Jun amino-terminal kinase Cell culture Cell size cell surface biotinylation Cells, Cultured Central nervous system Cerebral Cortex - cytology Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Extracellular signal-regulated kinase Gene Expression Regulation - drug effects Gene silencing Injuries Manganese Manganese - pharmacology manganese toxicity MAP kinase mitogen-activated protein kinases Movement disorders Neurodegenerative diseases Neurotoxicity Nitric-oxide synthase Oxidative stress oxidative/nitrosative stress Phosphorylation Plasma membranes Protein Multimerization - drug effects Rats RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction - drug effects tert-Butylhydroperoxide - pharmacology Time Factors Toxicity Trace Elements - pharmacology Transfection - methods
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