The early use of fibrinogen, prothrombin complex concentrate, and recombinant-activated factor VIIa in massive bleeding

Background Coagulopathy related to massive bleeding has a multifactorial aetiology. Coagulopathy is related to shock and blood loss including consumption of clotting factors and platelets and hemodilution. Additionally hyperfibrinolysis, hypothermia, acidosis, and metabolic changes affect the coagul...

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Veröffentlicht in:	Transfusion (Philadelphia, PA) PA), 2013-01, Vol.53 (S1), p.91S-95S
1. Verfasser:	Fries, Dietmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Coagulation Factors - therapeutic use Blood Component Transfusion Blood products Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Blood. Blood coagulation. Reticuloendothelial system Factor VIIa - therapeutic use Fibrinogen - therapeutic use Hemorrhage Hemorrhage - drug therapy Hemorrhage - etiology Humans Medical sciences Pharmacology. Drug treatments Recombinant Proteins - therapeutic use Transfusions. Complications. Transfusion reactions. Cell and gene therapy Trauma Severity Indices Wounds and Injuries - complications
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