l -Arginine enriched biscuits improve endothelial function and glucose metabolism: A pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome
Abstract Objective The aim of this study was to evaluate the effects of a new l -arginine-enriched biscuit on endothelial function, insulin sensitivity/secretion and body composition. Materials/Methods The project was composed of two studies. The first study was an acute pilot postprandial study in...
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| creator | Monti, Lucilla D Casiraghi, Maria C Setola, Emanuela Galluccio, Elena Pagani, Maria A Quaglia, Lucio Bosi, Emanuele Piatti, PierMarco |
| description | Abstract Objective The aim of this study was to evaluate the effects of a new l -arginine-enriched biscuit on endothelial function, insulin sensitivity/secretion and body composition. Materials/Methods The project was composed of two studies. The first study was an acute pilot postprandial study in 7 healthy subjects that evaluated bio-availability and vascular effects of l -arginine-enriched biscuits that contained 6.6 g l -arginine, 21.9 g carbohydrates, 3.6 g protein, 7.5 g fat and 4.3 g dietary fiber compared with placebo biscuits and 6.6 g powdered l -arginine. Subjects underwent the tests in random order, in at least 14-day intervals. The second study was a double-blind crossover study in 15 obese subjects with IGT and MS. These subjects consumed 6.6 g of l -arginine-enriched biscuits or placebo biscuits in a 1600 kcal diet. Each study period lasted 2 weeks with a 2-week washout in between. Endothelial function, glucose tolerance, insulin sensitivity and insulin secretion were evaluated at the end of each intervention period. Results In the first study, the groups that received the l -arginine-enriched biscuits and the powdered l -arginine had similarly increased l -arginine, NOx and cGMP levels and post-ischemic blood flow (PI-BF). In both cases, these levels were significantly higher than those in the placebo biscuit recipient group. In the second study, the l -arginine-enriched biscuit recipient group displayed increased l -arginine, NOx, cGMP, PI-BF, and Matsuda index levels, whereas their circulating glucose, proinsulin/insulin ratio and fat mass were decreased compared with the placebo biscuit recipient group. Conclusions l -Arginine-enriched biscuits with low sugar and protein content enhance endothelial function and improve glucose metabolism, insulin sensitivity and insulin secretion in subjects with IGT and MS. |
| doi_str_mv | 10.1016/j.metabol.2012.08.004 |
| format | Article |
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Materials/Methods The project was composed of two studies. The first study was an acute pilot postprandial study in 7 healthy subjects that evaluated bio-availability and vascular effects of l -arginine-enriched biscuits that contained 6.6 g l -arginine, 21.9 g carbohydrates, 3.6 g protein, 7.5 g fat and 4.3 g dietary fiber compared with placebo biscuits and 6.6 g powdered l -arginine. Subjects underwent the tests in random order, in at least 14-day intervals. The second study was a double-blind crossover study in 15 obese subjects with IGT and MS. These subjects consumed 6.6 g of l -arginine-enriched biscuits or placebo biscuits in a 1600 kcal diet. Each study period lasted 2 weeks with a 2-week washout in between. Endothelial function, glucose tolerance, insulin sensitivity and insulin secretion were evaluated at the end of each intervention period. Results In the first study, the groups that received the l -arginine-enriched biscuits and the powdered l -arginine had similarly increased l -arginine, NOx and cGMP levels and post-ischemic blood flow (PI-BF). In both cases, these levels were significantly higher than those in the placebo biscuit recipient group. In the second study, the l -arginine-enriched biscuit recipient group displayed increased l -arginine, NOx, cGMP, PI-BF, and Matsuda index levels, whereas their circulating glucose, proinsulin/insulin ratio and fat mass were decreased compared with the placebo biscuit recipient group. Conclusions l -Arginine-enriched biscuits with low sugar and protein content enhance endothelial function and improve glucose metabolism, insulin sensitivity and insulin secretion in subjects with IGT and MS.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/j.metabol.2012.08.004</identifier><identifier>PMID: 23040413</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Arginine - administration & dosage ; Biological and medical sciences ; Body Composition - physiology ; Body Weight - physiology ; Cholesterol - blood ; Cross-Over Studies ; Cyclic GMP - blood ; Diabetes. Impaired glucose tolerance ; Double-Blind Method ; Endocrine pancreas. Apud cells (diseases) ; Endocrinology & Metabolism ; Endocrinopathies ; Endothelium ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - metabolism ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Feeding. Feeding behavior ; Female ; Functional Food ; Fundamental and applied biological sciences. Psychology ; Glucose Intolerance - drug therapy ; Glucose Intolerance - metabolism ; Humans ; Insulin - metabolism ; Insulin Resistance ; Insulin Secretion ; l-Arginine ; Male ; Medical sciences ; Metabolic diseases ; Metabolic Syndrome - blood ; Metabolic Syndrome - drug therapy ; Metabolic Syndrome - metabolism ; Middle Aged ; Miscellaneous ; Nitric Oxide Synthase Type II - blood ; Obesity - blood ; Obesity - drug therapy ; Obesity - metabolism ; Other metabolic disorders ; Pilot Projects ; Snacks ; Triglycerides - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Metabolism, clinical and experimental, 2013-02, Vol.62 (2), p.255-264</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-34b1c80089396ece53f37cae4c18f67cec436cff6ed9d9063c86ba3dd04533733</citedby><cites>FETCH-LOGICAL-c483t-34b1c80089396ece53f37cae4c18f67cec436cff6ed9d9063c86ba3dd04533733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026049512003083$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27109982$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23040413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monti, Lucilla D</creatorcontrib><creatorcontrib>Casiraghi, Maria C</creatorcontrib><creatorcontrib>Setola, Emanuela</creatorcontrib><creatorcontrib>Galluccio, Elena</creatorcontrib><creatorcontrib>Pagani, Maria A</creatorcontrib><creatorcontrib>Quaglia, Lucio</creatorcontrib><creatorcontrib>Bosi, Emanuele</creatorcontrib><creatorcontrib>Piatti, PierMarco</creatorcontrib><title>l -Arginine enriched biscuits improve endothelial function and glucose metabolism: A pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>Abstract Objective The aim of this study was to evaluate the effects of a new l -arginine-enriched biscuit on endothelial function, insulin sensitivity/secretion and body composition. Materials/Methods The project was composed of two studies. The first study was an acute pilot postprandial study in 7 healthy subjects that evaluated bio-availability and vascular effects of l -arginine-enriched biscuits that contained 6.6 g l -arginine, 21.9 g carbohydrates, 3.6 g protein, 7.5 g fat and 4.3 g dietary fiber compared with placebo biscuits and 6.6 g powdered l -arginine. Subjects underwent the tests in random order, in at least 14-day intervals. The second study was a double-blind crossover study in 15 obese subjects with IGT and MS. These subjects consumed 6.6 g of l -arginine-enriched biscuits or placebo biscuits in a 1600 kcal diet. Each study period lasted 2 weeks with a 2-week washout in between. Endothelial function, glucose tolerance, insulin sensitivity and insulin secretion were evaluated at the end of each intervention period. Results In the first study, the groups that received the l -arginine-enriched biscuits and the powdered l -arginine had similarly increased l -arginine, NOx and cGMP levels and post-ischemic blood flow (PI-BF). In both cases, these levels were significantly higher than those in the placebo biscuit recipient group. In the second study, the l -arginine-enriched biscuit recipient group displayed increased l -arginine, NOx, cGMP, PI-BF, and Matsuda index levels, whereas their circulating glucose, proinsulin/insulin ratio and fat mass were decreased compared with the placebo biscuit recipient group. Conclusions l -Arginine-enriched biscuits with low sugar and protein content enhance endothelial function and improve glucose metabolism, insulin sensitivity and insulin secretion in subjects with IGT and MS.</description><subject>Arginine - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Body Composition - physiology</subject><subject>Body Weight - physiology</subject><subject>Cholesterol - blood</subject><subject>Cross-Over Studies</subject><subject>Cyclic GMP - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Double-Blind Method</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinology & Metabolism</subject><subject>Endocrinopathies</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Functional Food</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Intolerance - drug therapy</subject><subject>Glucose Intolerance - metabolism</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Insulin Resistance</subject><subject>Insulin Secretion</subject><subject>l-Arginine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - drug therapy</subject><subject>Metabolic Syndrome - metabolism</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Nitric Oxide Synthase Type II - blood</subject><subject>Obesity - blood</subject><subject>Obesity - drug therapy</subject><subject>Obesity - metabolism</subject><subject>Other metabolic disorders</subject><subject>Pilot Projects</subject><subject>Snacks</subject><subject>Triglycerides - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2O0zAUhSMEYkrhEUDeILFJuY7z47AAVSP-pJFYAGvLsW-mLk5cbGdQXpJnwpl2phKbWWWR755zfc7NspcUNhRo_Xa_GTDKztlNAbTYAN8AlI-yFa1YkfMa4HG2AijqHMq2usiehbAHgKbh9dPsomBQQknZKvtrSb7112Y0IxIcvVE71KQzQU0mBmKGg3c3yx_t4g6tkZb006iicSORoybXdlIuIDktY8LwjmzJwVgXSYiTnokZyQ6ljbuZhKnbo0qyy6QkyrsQ8iTvz-g98sfE3WIvjcezTXQWvRwV3krcmSoS5lF7N-Dz7EkvbcAXp-86-_np44_LL_nVt89fL7dXuSo5izkrO6o4AG9ZW6PCivWsURJLRXlfNwpVyWrV9zXqVrdQM8XrTjKtoawYaxhbZ2-Ouime3xOGKIYUGVorR3RTELSpeME4L5uH0aJhDU_LQEKrI3qbjMdeHLwZpJ8FBbG0Lvbi9GaxtC6Ai9R6mnt1spi6AfX91F3NCXh9AmRQ0vZLhCacuYZC26aF19mHI4cpuxuDXgRlMMWtUwsqCu3Mg6u8_09B2XRcyfQXzhj2bvJjKkZQEdKM-L6c6HKhtEjvB87YP7XQ53Y</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Monti, Lucilla D</creator><creator>Casiraghi, Maria C</creator><creator>Setola, Emanuela</creator><creator>Galluccio, Elena</creator><creator>Pagani, Maria A</creator><creator>Quaglia, Lucio</creator><creator>Bosi, Emanuele</creator><creator>Piatti, PierMarco</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130201</creationdate><title>l -Arginine enriched biscuits improve endothelial function and glucose metabolism: A pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome</title><author>Monti, Lucilla D ; Casiraghi, Maria C ; Setola, Emanuela ; Galluccio, Elena ; Pagani, Maria A ; Quaglia, Lucio ; Bosi, Emanuele ; Piatti, PierMarco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-34b1c80089396ece53f37cae4c18f67cec436cff6ed9d9063c86ba3dd04533733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Arginine - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Body Composition - physiology</topic><topic>Body Weight - physiology</topic><topic>Cholesterol - blood</topic><topic>Cross-Over Studies</topic><topic>Cyclic GMP - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Double-Blind Method</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinology & Metabolism</topic><topic>Endocrinopathies</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Functional Food</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Intolerance - drug therapy</topic><topic>Glucose Intolerance - metabolism</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Insulin Resistance</topic><topic>Insulin Secretion</topic><topic>l-Arginine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - drug therapy</topic><topic>Metabolic Syndrome - metabolism</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Nitric Oxide Synthase Type II - blood</topic><topic>Obesity - blood</topic><topic>Obesity - drug therapy</topic><topic>Obesity - metabolism</topic><topic>Other metabolic disorders</topic><topic>Pilot Projects</topic><topic>Snacks</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monti, Lucilla D</creatorcontrib><creatorcontrib>Casiraghi, Maria C</creatorcontrib><creatorcontrib>Setola, Emanuela</creatorcontrib><creatorcontrib>Galluccio, Elena</creatorcontrib><creatorcontrib>Pagani, Maria A</creatorcontrib><creatorcontrib>Quaglia, Lucio</creatorcontrib><creatorcontrib>Bosi, Emanuele</creatorcontrib><creatorcontrib>Piatti, PierMarco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monti, Lucilla D</au><au>Casiraghi, Maria C</au><au>Setola, Emanuela</au><au>Galluccio, Elena</au><au>Pagani, Maria A</au><au>Quaglia, Lucio</au><au>Bosi, Emanuele</au><au>Piatti, PierMarco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>l -Arginine enriched biscuits improve endothelial function and glucose metabolism: A pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>62</volume><issue>2</issue><spage>255</spage><epage>264</epage><pages>255-264</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>Abstract Objective The aim of this study was to evaluate the effects of a new l -arginine-enriched biscuit on endothelial function, insulin sensitivity/secretion and body composition. Materials/Methods The project was composed of two studies. The first study was an acute pilot postprandial study in 7 healthy subjects that evaluated bio-availability and vascular effects of l -arginine-enriched biscuits that contained 6.6 g l -arginine, 21.9 g carbohydrates, 3.6 g protein, 7.5 g fat and 4.3 g dietary fiber compared with placebo biscuits and 6.6 g powdered l -arginine. Subjects underwent the tests in random order, in at least 14-day intervals. The second study was a double-blind crossover study in 15 obese subjects with IGT and MS. These subjects consumed 6.6 g of l -arginine-enriched biscuits or placebo biscuits in a 1600 kcal diet. Each study period lasted 2 weeks with a 2-week washout in between. Endothelial function, glucose tolerance, insulin sensitivity and insulin secretion were evaluated at the end of each intervention period. Results In the first study, the groups that received the l -arginine-enriched biscuits and the powdered l -arginine had similarly increased l -arginine, NOx and cGMP levels and post-ischemic blood flow (PI-BF). In both cases, these levels were significantly higher than those in the placebo biscuit recipient group. In the second study, the l -arginine-enriched biscuit recipient group displayed increased l -arginine, NOx, cGMP, PI-BF, and Matsuda index levels, whereas their circulating glucose, proinsulin/insulin ratio and fat mass were decreased compared with the placebo biscuit recipient group. Conclusions l -Arginine-enriched biscuits with low sugar and protein content enhance endothelial function and improve glucose metabolism, insulin sensitivity and insulin secretion in subjects with IGT and MS.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23040413</pmid><doi>10.1016/j.metabol.2012.08.004</doi><tpages>10</tpages></addata></record> |
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| subjects | Arginine - administration & dosage Biological and medical sciences Body Composition - physiology Body Weight - physiology Cholesterol - blood Cross-Over Studies Cyclic GMP - blood Diabetes. Impaired glucose tolerance Double-Blind Method Endocrine pancreas. Apud cells (diseases) Endocrinology & Metabolism Endocrinopathies Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Etiopathogenesis. Screening. Investigations. Target tissue resistance Feeding. Feeding behavior Female Functional Food Fundamental and applied biological sciences. Psychology Glucose Intolerance - drug therapy Glucose Intolerance - metabolism Humans Insulin - metabolism Insulin Resistance Insulin Secretion l-Arginine Male Medical sciences Metabolic diseases Metabolic Syndrome - blood Metabolic Syndrome - drug therapy Metabolic Syndrome - metabolism Middle Aged Miscellaneous Nitric Oxide Synthase Type II - blood Obesity - blood Obesity - drug therapy Obesity - metabolism Other metabolic disorders Pilot Projects Snacks Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | l -Arginine enriched biscuits improve endothelial function and glucose metabolism: A pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome |
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