A gene variant of 11β-hydroxysteroid dehydrogenase type 1 is associated with obesity in children

Background: The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme catalyses the regeneration of active cortisol from inert cortisone and plays a critical role in tissue-specific corticosteroid reactions; therefore, 11β-HSD1 is a key molecule associated with the development of obesity. Despit...

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Veröffentlicht in:	International Journal of Obesity 2012-12, Vol.36 (12), p.1558-1563
Hauptverfasser:	Olza, J, Gil-Campos, M, Leis, R, Rupérez, A I, Tojo, R, Cañete, R, Gil, A, Aguilera, C M
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - genetics 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism 692/420/2489/144 692/699/1702/393 692/700/1720 692/700/478/174 Adolescent Age of Onset Biological and medical sciences Biomarkers - blood Body Composition - genetics Body Mass Index Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Case-Control Studies Child Development and progression Epidemiology Female Gene Expression Profiling General aspects Genetic aspects Genetic Predisposition to Disease Genetic variation Genotype Health aspects Health Promotion and Disease Prevention Humans Inflammation - blood Inflammation - genetics Insulin Resistance Internal Medicine Liver - metabolism Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Obesity Obesity - epidemiology Obesity - genetics Obesity - metabolism Obesity in children original-article Oxidoreductases Physiological aspects Polymorphism, Single Nucleotide Prospective Studies Public Health Spain - epidemiology Steroid hormones
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