Cognitive and Psychological Impact of BRCA Genetic Counseling in Before and After Definitive Surgery Breast Cancer Patients
Purpose To examine changes in cancer-related knowledge, distress, and decisional conflict from pre- to post-genetic counseling (GC) in before (BDS) and after (ADS) definitive surgery breast cancer (BC) patients. Methods Sociodemographic and clinical characteristics were collected at baseline; primar...
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| Veröffentlicht in: | Annals of surgical oncology 2012-12, Vol.19 (13), p.4003-4011 |
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| container_title | Annals of surgical oncology |
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| creator | Christie, Juliette Quinn, Gwendolyn P. Malo, Teri Lee, Ji-Hyun Zhao, Xiuhua McIntyre, Jessica Brzosowicz, Jennifer Jacobsen, Paul B. Vadaparampil, Susan T. |
| description | Purpose
To examine changes in cancer-related knowledge, distress, and decisional conflict from pre- to post-genetic counseling (GC) in before (BDS) and after (ADS) definitive surgery breast cancer (BC) patients.
Methods
Sociodemographic and clinical characteristics were collected at baseline; primary outcome data were collected before (T1) and after (T2) pretest GC. Within group changes for cancer-related knowledge, distress, and decisional conflict over genetic testing were compared by Wilcoxon signed-rank tests.
Results
Of 103 BC patients, 87 were ADS and 16 were BDS. Analyses revealed that both groups reported significant increases in knowledge between T1 and T2 (median change 4.2,
p
= 0.004, and 2.7,
p
|
| doi_str_mv | 10.1245/s10434-012-2460-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1758238763</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1758238763</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-b5dbbf7792dc265f630024e00a0a9db7070f341a3efc5fe1a06e96ed78830d7c3</originalsourceid><addsrcrecordid>eNqFkU2LFDEQhhtR3HX1B3iRgBcvrZWPTrqPM62uCwsufpxDJl0Zs_QkY9K97OCfN0OPIoJIHVIkz_sWlbeqnlN4TZlo3mQKgosaKKuZkFDfP6jOaVNuhGzpw9KDbOuOyeasepLzLQBVHJrH1RljSsquFefVjz5ug5_8HRITBnKTD_ZbHOPWWzOSq93e2IlER9af-hW5xICTt6SPc8g4-rAlPpA1upgW9cpNmMhbdP5k-XlOW0wHsk5o8kR6E2wBbszkMUz5afXImTHjs9N5UX19_-5L_6G-_nh51a-uaytEO9WbZthsnFIdG2zZxUkOwAQCGDDdsFGgwHFBDUdnG4fUgMRO4qDalsOgLL-oXi2--xS_z5gnvfPZ4jiagHHOmqqmZbxVkv8fZQy4LHVEX_6F3sY5hbKIprRTILlqZaHoQtkUc07o9D75nUkHTUEfQ9RLiLqEqI8h6vuieXFynjc7HH4rfqVWALYAuTyF8sN_jP6n608Ntacp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1197063786</pqid></control><display><type>article</type><title>Cognitive and Psychological Impact of BRCA Genetic Counseling in Before and After Definitive Surgery Breast Cancer Patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Christie, Juliette ; Quinn, Gwendolyn P. ; Malo, Teri ; Lee, Ji-Hyun ; Zhao, Xiuhua ; McIntyre, Jessica ; Brzosowicz, Jennifer ; Jacobsen, Paul B. ; Vadaparampil, Susan T.</creator><creatorcontrib>Christie, Juliette ; Quinn, Gwendolyn P. ; Malo, Teri ; Lee, Ji-Hyun ; Zhao, Xiuhua ; McIntyre, Jessica ; Brzosowicz, Jennifer ; Jacobsen, Paul B. ; Vadaparampil, Susan T.</creatorcontrib><description>Purpose
To examine changes in cancer-related knowledge, distress, and decisional conflict from pre- to post-genetic counseling (GC) in before (BDS) and after (ADS) definitive surgery breast cancer (BC) patients.
Methods
Sociodemographic and clinical characteristics were collected at baseline; primary outcome data were collected before (T1) and after (T2) pretest GC. Within group changes for cancer-related knowledge, distress, and decisional conflict over genetic testing were compared by Wilcoxon signed-rank tests.
Results
Of 103 BC patients, 87 were ADS and 16 were BDS. Analyses revealed that both groups reported significant increases in knowledge between T1 and T2 (median change 4.2,
p
= 0.004, and 2.7,
p
< 0.001, for BDS and ADS patients, respectively). Overall cancer-related distress showed a downward trend between T1 and T2 for both groups and was significant for BDS patients (
p
= 0.041). Reports of BDS patients trended toward overall and subscale-specific increases in decisional conflict, with the exception of the uncertainty which trended downward, but did not reach significance. Overall decisional conflict decreased in ADS patients, approaching marginal significance (
p
= 0.056), with significant improvements in informed decision making (median change −12.6,
p
< 0.001; i.e., pretest GC yielded improved knowledge of benefits, risks, and side effects of available options).
Conclusions
These pilot data suggest that pretest GC increases cancer-related knowledge for both BDS and ADS patients, decreases distress in BDS patients, and improves informed decision making in ADS patients. Future studies with larger sample sizes are needed to replicate these results.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-012-2460-x</identifier><identifier>PMID: 22766984</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Aged ; BRCA1 Protein - genetics ; BRCA2 Protein - genetics ; Breast Neoplasms - genetics ; Breast Neoplasms - psychology ; Breast Neoplasms - surgery ; Cognition ; Conflict (Psychology) ; Decision Making ; Female ; Genetic Counseling ; Genetic Predisposition to Disease ; Genetic Testing ; Healthcare Policy and Outcomes ; Humans ; Knowledge ; Medicine ; Medicine & Public Health ; Middle Aged ; Mutation - genetics ; Oncology ; Surgery ; Surgical Oncology ; Young Adult</subject><ispartof>Annals of surgical oncology, 2012-12, Vol.19 (13), p.4003-4011</ispartof><rights>Society of Surgical Oncology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-b5dbbf7792dc265f630024e00a0a9db7070f341a3efc5fe1a06e96ed78830d7c3</citedby><cites>FETCH-LOGICAL-c448t-b5dbbf7792dc265f630024e00a0a9db7070f341a3efc5fe1a06e96ed78830d7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-012-2460-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-012-2460-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27906,27907,41470,42539,51301</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22766984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Christie, Juliette</creatorcontrib><creatorcontrib>Quinn, Gwendolyn P.</creatorcontrib><creatorcontrib>Malo, Teri</creatorcontrib><creatorcontrib>Lee, Ji-Hyun</creatorcontrib><creatorcontrib>Zhao, Xiuhua</creatorcontrib><creatorcontrib>McIntyre, Jessica</creatorcontrib><creatorcontrib>Brzosowicz, Jennifer</creatorcontrib><creatorcontrib>Jacobsen, Paul B.</creatorcontrib><creatorcontrib>Vadaparampil, Susan T.</creatorcontrib><title>Cognitive and Psychological Impact of BRCA Genetic Counseling in Before and After Definitive Surgery Breast Cancer Patients</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Purpose
To examine changes in cancer-related knowledge, distress, and decisional conflict from pre- to post-genetic counseling (GC) in before (BDS) and after (ADS) definitive surgery breast cancer (BC) patients.
Methods
Sociodemographic and clinical characteristics were collected at baseline; primary outcome data were collected before (T1) and after (T2) pretest GC. Within group changes for cancer-related knowledge, distress, and decisional conflict over genetic testing were compared by Wilcoxon signed-rank tests.
Results
Of 103 BC patients, 87 were ADS and 16 were BDS. Analyses revealed that both groups reported significant increases in knowledge between T1 and T2 (median change 4.2,
p
= 0.004, and 2.7,
p
< 0.001, for BDS and ADS patients, respectively). Overall cancer-related distress showed a downward trend between T1 and T2 for both groups and was significant for BDS patients (
p
= 0.041). Reports of BDS patients trended toward overall and subscale-specific increases in decisional conflict, with the exception of the uncertainty which trended downward, but did not reach significance. Overall decisional conflict decreased in ADS patients, approaching marginal significance (
p
= 0.056), with significant improvements in informed decision making (median change −12.6,
p
< 0.001; i.e., pretest GC yielded improved knowledge of benefits, risks, and side effects of available options).
Conclusions
These pilot data suggest that pretest GC increases cancer-related knowledge for both BDS and ADS patients, decreases distress in BDS patients, and improves informed decision making in ADS patients. Future studies with larger sample sizes are needed to replicate these results.</description><subject>Adult</subject><subject>Aged</subject><subject>BRCA1 Protein - genetics</subject><subject>BRCA2 Protein - genetics</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - psychology</subject><subject>Breast Neoplasms - surgery</subject><subject>Cognition</subject><subject>Conflict (Psychology)</subject><subject>Decision Making</subject><subject>Female</subject><subject>Genetic Counseling</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Testing</subject><subject>Healthcare Policy and Outcomes</subject><subject>Humans</subject><subject>Knowledge</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mutation - genetics</subject><subject>Oncology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Young Adult</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkU2LFDEQhhtR3HX1B3iRgBcvrZWPTrqPM62uCwsufpxDJl0Zs_QkY9K97OCfN0OPIoJIHVIkz_sWlbeqnlN4TZlo3mQKgosaKKuZkFDfP6jOaVNuhGzpw9KDbOuOyeasepLzLQBVHJrH1RljSsquFefVjz5ug5_8HRITBnKTD_ZbHOPWWzOSq93e2IlER9af-hW5xICTt6SPc8g4-rAlPpA1upgW9cpNmMhbdP5k-XlOW0wHsk5o8kR6E2wBbszkMUz5afXImTHjs9N5UX19_-5L_6G-_nh51a-uaytEO9WbZthsnFIdG2zZxUkOwAQCGDDdsFGgwHFBDUdnG4fUgMRO4qDalsOgLL-oXi2--xS_z5gnvfPZ4jiagHHOmqqmZbxVkv8fZQy4LHVEX_6F3sY5hbKIprRTILlqZaHoQtkUc07o9D75nUkHTUEfQ9RLiLqEqI8h6vuieXFynjc7HH4rfqVWALYAuTyF8sN_jP6n608Ntacp</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Christie, Juliette</creator><creator>Quinn, Gwendolyn P.</creator><creator>Malo, Teri</creator><creator>Lee, Ji-Hyun</creator><creator>Zhao, Xiuhua</creator><creator>McIntyre, Jessica</creator><creator>Brzosowicz, Jennifer</creator><creator>Jacobsen, Paul B.</creator><creator>Vadaparampil, Susan T.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20121201</creationdate><title>Cognitive and Psychological Impact of BRCA Genetic Counseling in Before and After Definitive Surgery Breast Cancer Patients</title><author>Christie, Juliette ; Quinn, Gwendolyn P. ; Malo, Teri ; Lee, Ji-Hyun ; Zhao, Xiuhua ; McIntyre, Jessica ; Brzosowicz, Jennifer ; Jacobsen, Paul B. ; Vadaparampil, Susan T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-b5dbbf7792dc265f630024e00a0a9db7070f341a3efc5fe1a06e96ed78830d7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>BRCA1 Protein - genetics</topic><topic>BRCA2 Protein - genetics</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - psychology</topic><topic>Breast Neoplasms - surgery</topic><topic>Cognition</topic><topic>Conflict (Psychology)</topic><topic>Decision Making</topic><topic>Female</topic><topic>Genetic Counseling</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Testing</topic><topic>Healthcare Policy and Outcomes</topic><topic>Humans</topic><topic>Knowledge</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mutation - genetics</topic><topic>Oncology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christie, Juliette</creatorcontrib><creatorcontrib>Quinn, Gwendolyn P.</creatorcontrib><creatorcontrib>Malo, Teri</creatorcontrib><creatorcontrib>Lee, Ji-Hyun</creatorcontrib><creatorcontrib>Zhao, Xiuhua</creatorcontrib><creatorcontrib>McIntyre, Jessica</creatorcontrib><creatorcontrib>Brzosowicz, Jennifer</creatorcontrib><creatorcontrib>Jacobsen, Paul B.</creatorcontrib><creatorcontrib>Vadaparampil, Susan T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christie, Juliette</au><au>Quinn, Gwendolyn P.</au><au>Malo, Teri</au><au>Lee, Ji-Hyun</au><au>Zhao, Xiuhua</au><au>McIntyre, Jessica</au><au>Brzosowicz, Jennifer</au><au>Jacobsen, Paul B.</au><au>Vadaparampil, Susan T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive and Psychological Impact of BRCA Genetic Counseling in Before and After Definitive Surgery Breast Cancer Patients</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>19</volume><issue>13</issue><spage>4003</spage><epage>4011</epage><pages>4003-4011</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Purpose
To examine changes in cancer-related knowledge, distress, and decisional conflict from pre- to post-genetic counseling (GC) in before (BDS) and after (ADS) definitive surgery breast cancer (BC) patients.
Methods
Sociodemographic and clinical characteristics were collected at baseline; primary outcome data were collected before (T1) and after (T2) pretest GC. Within group changes for cancer-related knowledge, distress, and decisional conflict over genetic testing were compared by Wilcoxon signed-rank tests.
Results
Of 103 BC patients, 87 were ADS and 16 were BDS. Analyses revealed that both groups reported significant increases in knowledge between T1 and T2 (median change 4.2,
p
= 0.004, and 2.7,
p
< 0.001, for BDS and ADS patients, respectively). Overall cancer-related distress showed a downward trend between T1 and T2 for both groups and was significant for BDS patients (
p
= 0.041). Reports of BDS patients trended toward overall and subscale-specific increases in decisional conflict, with the exception of the uncertainty which trended downward, but did not reach significance. Overall decisional conflict decreased in ADS patients, approaching marginal significance (
p
= 0.056), with significant improvements in informed decision making (median change −12.6,
p
< 0.001; i.e., pretest GC yielded improved knowledge of benefits, risks, and side effects of available options).
Conclusions
These pilot data suggest that pretest GC increases cancer-related knowledge for both BDS and ADS patients, decreases distress in BDS patients, and improves informed decision making in ADS patients. Future studies with larger sample sizes are needed to replicate these results.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22766984</pmid><doi>10.1245/s10434-012-2460-x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2012-12, Vol.19 (13), p.4003-4011 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1758238763 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged BRCA1 Protein - genetics BRCA2 Protein - genetics Breast Neoplasms - genetics Breast Neoplasms - psychology Breast Neoplasms - surgery Cognition Conflict (Psychology) Decision Making Female Genetic Counseling Genetic Predisposition to Disease Genetic Testing Healthcare Policy and Outcomes Humans Knowledge Medicine Medicine & Public Health Middle Aged Mutation - genetics Oncology Surgery Surgical Oncology Young Adult |
| title | Cognitive and Psychological Impact of BRCA Genetic Counseling in Before and After Definitive Surgery Breast Cancer Patients |
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