Gene Expression of Surfactant Protein-A and Thyroid Transcription Factor-1 in Lungs of Rats Exposed to Silicon-Carbide Whisker in vivo
Gene Expression of Surfactant Protein-A and Thyroid Transcription Factor-1 in Lungs of Rats Exposed to Silicon-Carbide Whisker in vivo : Yasuo MORIMOTO, et al. Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health-Intratracheal instillation studies have...
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| creator | Morimoto, Yasuo Ding, Li Oyabu, Takako Kim, Heungnam Ogami, Akira Hirohashi, Masami Nagatomo, Hiroko Yamato, Hiroshi Akiyama, Izumi Hori, Hajime Higashi, Toshiaki Tanaka, Isamu |
| description | Gene Expression of Surfactant Protein-A and Thyroid Transcription Factor-1 in Lungs of Rats Exposed to Silicon-Carbide Whisker in vivo : Yasuo MORIMOTO, et al. Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health-Intratracheal instillation studies have shown that exposure to silicon carbide whisker (SiCW), an asbestos substitute, produces pulmonary fibrotic changes, suggesting that SICW might have a fibrogenic potential. It is thought that surfactant protein is a good biomarker of lung injury and pulmonary fibrotic activity. In order to explore whether or not surfactant protein is associated with lung disorder through exposure to SiCW, we examined the expression of SP-A, SP-C and thyroid transcription factor-1 (TTF-1 ), a common transcription factor of SP-A and SP-C mRNA in lungs exposed to SiCW. Male Wistar rats were administered 2 mg or 10 mg of SiCW suspended in saline by a single intratracheal instillation, and were sacrificed at 3 d, 1 wk, 1 month, 3 months and 6 months after the intratracheal instillation. RNA was subsequently extracted from the lungs, and expression of SP-A, SP-C and TTF-1 mRNA from the lungs was observed by reverse transcription-polymerase chain reaction (RT-PCR). Exposure to 2 mg of SiCW showed a decrease in mRNA of SP-A and TTF-1 at 6 months, but exposure to 10 mg of SiCW showed decreased levels of SP-A and TTF-1 mRNA at 3 d and 6 months. On the other hand, 2 mg of SiCW increased the level of SP-C mRNA from 3 d to 3 months, and 10 mg of SiCW decreased the levels of SP-C mRNA in the rat lungs at 3 d, 1 month and 6 months. No clear tendency to the expression of SP-C was observed, but the patterns of expression of TTF-1 and SP-A were similar. These data suggest that SP-A and TTF-1 are associated with not only the acute phase but also the chronic phase in lungs exposed to SiCW. (J Occup Health 2003 ; 45 : 307-3 12) |
| doi_str_mv | 10.1539/joh.45.307 |
| format | Article |
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Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health-Intratracheal instillation studies have shown that exposure to silicon carbide whisker (SiCW), an asbestos substitute, produces pulmonary fibrotic changes, suggesting that SICW might have a fibrogenic potential. It is thought that surfactant protein is a good biomarker of lung injury and pulmonary fibrotic activity. In order to explore whether or not surfactant protein is associated with lung disorder through exposure to SiCW, we examined the expression of SP-A, SP-C and thyroid transcription factor-1 (TTF-1 ), a common transcription factor of SP-A and SP-C mRNA in lungs exposed to SiCW. Male Wistar rats were administered 2 mg or 10 mg of SiCW suspended in saline by a single intratracheal instillation, and were sacrificed at 3 d, 1 wk, 1 month, 3 months and 6 months after the intratracheal instillation. RNA was subsequently extracted from the lungs, and expression of SP-A, SP-C and TTF-1 mRNA from the lungs was observed by reverse transcription-polymerase chain reaction (RT-PCR). Exposure to 2 mg of SiCW showed a decrease in mRNA of SP-A and TTF-1 at 6 months, but exposure to 10 mg of SiCW showed decreased levels of SP-A and TTF-1 mRNA at 3 d and 6 months. On the other hand, 2 mg of SiCW increased the level of SP-C mRNA from 3 d to 3 months, and 10 mg of SiCW decreased the levels of SP-C mRNA in the rat lungs at 3 d, 1 month and 6 months. No clear tendency to the expression of SP-C was observed, but the patterns of expression of TTF-1 and SP-A were similar. These data suggest that SP-A and TTF-1 are associated with not only the acute phase but also the chronic phase in lungs exposed to SiCW. (J Occup Health 2003 ; 45 : 307-3 12)</description><identifier>ISSN: 1341-9145</identifier><identifier>ISSN: 1348-9585</identifier><identifier>EISSN: 1348-9585</identifier><identifier>DOI: 10.1539/joh.45.307</identifier><identifier>PMID: 14646272</identifier><language>eng</language><publisher>Australia: JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</publisher><subject>Animals ; Asbestos ; Gene Expression ; Lung ; Lung Diseases - pathology ; Lungs ; Nuclear Proteins - genetics ; Occupational health ; Proteins ; Pulmonary Surfactant-Associated Protein A - genetics ; Rats ; Rats, Wistar ; Reverse Transcriptase Polymerase Chain Reaction ; Rodents ; RT‐PCR ; Silicon ; Silicon carbide whisker ; Silicon Compounds - toxicity ; SP‐A ; SP‐C ; Statistics, Nonparametric ; Surfactants ; Thyroid ; Thyroid gland ; Thyroid Nuclear Factor 1 ; Transcription factors ; Transcription Factors - genetics ; Transcription, Genetic ; TTF‐1</subject><ispartof>Journal of Occupational Health, 2003-09, Vol.45 (5), p.307-312</ispartof><rights>2003 Japan Society for Occupational Health</rights><rights>Copyright Japan Science and Technology Agency 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6616-9d859fe1749394b48ff154c850307f1924b7948bd5e3875aba4354974f7d44273</citedby><cites>FETCH-LOGICAL-c6616-9d859fe1749394b48ff154c850307f1924b7948bd5e3875aba4354974f7d44273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1539%2Fjoh.45.307$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1539%2Fjoh.45.307$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14646272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morimoto, Yasuo</creatorcontrib><creatorcontrib>Ding, Li</creatorcontrib><creatorcontrib>Oyabu, Takako</creatorcontrib><creatorcontrib>Kim, Heungnam</creatorcontrib><creatorcontrib>Ogami, Akira</creatorcontrib><creatorcontrib>Hirohashi, Masami</creatorcontrib><creatorcontrib>Nagatomo, Hiroko</creatorcontrib><creatorcontrib>Yamato, Hiroshi</creatorcontrib><creatorcontrib>Akiyama, Izumi</creatorcontrib><creatorcontrib>Hori, Hajime</creatorcontrib><creatorcontrib>Higashi, Toshiaki</creatorcontrib><creatorcontrib>Tanaka, Isamu</creatorcontrib><creatorcontrib>School of Health Sciences</creatorcontrib><creatorcontrib>Institute of Industrial and Ecological Sciences</creatorcontrib><creatorcontrib>Japan</creatorcontrib><creatorcontrib>University of Occupational and Environmental Health</creatorcontrib><title>Gene Expression of Surfactant Protein-A and Thyroid Transcription Factor-1 in Lungs of Rats Exposed to Silicon-Carbide Whisker in vivo</title><title>Journal of Occupational Health</title><addtitle>J Occup Health</addtitle><description>Gene Expression of Surfactant Protein-A and Thyroid Transcription Factor-1 in Lungs of Rats Exposed to Silicon-Carbide Whisker in vivo : Yasuo MORIMOTO, et al. Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health-Intratracheal instillation studies have shown that exposure to silicon carbide whisker (SiCW), an asbestos substitute, produces pulmonary fibrotic changes, suggesting that SICW might have a fibrogenic potential. It is thought that surfactant protein is a good biomarker of lung injury and pulmonary fibrotic activity. In order to explore whether or not surfactant protein is associated with lung disorder through exposure to SiCW, we examined the expression of SP-A, SP-C and thyroid transcription factor-1 (TTF-1 ), a common transcription factor of SP-A and SP-C mRNA in lungs exposed to SiCW. Male Wistar rats were administered 2 mg or 10 mg of SiCW suspended in saline by a single intratracheal instillation, and were sacrificed at 3 d, 1 wk, 1 month, 3 months and 6 months after the intratracheal instillation. RNA was subsequently extracted from the lungs, and expression of SP-A, SP-C and TTF-1 mRNA from the lungs was observed by reverse transcription-polymerase chain reaction (RT-PCR). Exposure to 2 mg of SiCW showed a decrease in mRNA of SP-A and TTF-1 at 6 months, but exposure to 10 mg of SiCW showed decreased levels of SP-A and TTF-1 mRNA at 3 d and 6 months. On the other hand, 2 mg of SiCW increased the level of SP-C mRNA from 3 d to 3 months, and 10 mg of SiCW decreased the levels of SP-C mRNA in the rat lungs at 3 d, 1 month and 6 months. No clear tendency to the expression of SP-C was observed, but the patterns of expression of TTF-1 and SP-A were similar. These data suggest that SP-A and TTF-1 are associated with not only the acute phase but also the chronic phase in lungs exposed to SiCW. (J Occup Health 2003 ; 45 : 307-3 12)</description><subject>Animals</subject><subject>Asbestos</subject><subject>Gene Expression</subject><subject>Lung</subject><subject>Lung Diseases - pathology</subject><subject>Lungs</subject><subject>Nuclear Proteins - genetics</subject><subject>Occupational health</subject><subject>Proteins</subject><subject>Pulmonary Surfactant-Associated Protein A - genetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Rodents</subject><subject>RT‐PCR</subject><subject>Silicon</subject><subject>Silicon carbide whisker</subject><subject>Silicon Compounds - toxicity</subject><subject>SP‐A</subject><subject>SP‐C</subject><subject>Statistics, Nonparametric</subject><subject>Surfactants</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Nuclear Factor 1</subject><subject>Transcription factors</subject><subject>Transcription Factors - genetics</subject><subject>Transcription, Genetic</subject><subject>TTF‐1</subject><issn>1341-9145</issn><issn>1348-9585</issn><issn>1348-9585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdFqFDEUhoMottTe-AASELwQZk0mJ8nksizdVlmo2IqXITOTuKmzyZrMVPcFfG4z3YWCF0LIOZDv__lzDkKvKVlQztSH-7hZAF8wIp-hU8qgqRRv-PPHnlaKAj9B5zn7ltSMckkFe4lOKAgQtaxP0Z8rGyy-_L1LtkAx4Ojw7ZSc6UYTRvw5xdH6UF1gE3p8t9mn6EtNJuQu-d04K1aFjami2Ae8nsL3PHt8MWOebWO2PR4jvvWD72Kolia1vrf428bnHzbNmgf_EF-hF84M2Z4f6xn6urq8W15X65urj8uLddUJQUWl-oYrZ6kExRS00DhHOXQNJ-X_jqoaWqmgaXtuWSO5aQ0wDkqCkz1ALdkZenfw3aX4c7J51FufOzsMJtg4ZU0ll0ICFPDtP-B9nFIo2TQtzxIoKFGo9weqSzHnZJ3eJb81aa8p0fN6imqjgesSr8BvjpZTu7X9E3pcRgH4AfjlB7v_j5X-dHNdE-CElDOnWB10xdV3Zohh8ME-Be6cfOx1TQjTZBbyUoSep1YuWpfZCsXYX_CZr84</recordid><startdate>200309</startdate><enddate>200309</enddate><creator>Morimoto, Yasuo</creator><creator>Ding, Li</creator><creator>Oyabu, Takako</creator><creator>Kim, Heungnam</creator><creator>Ogami, Akira</creator><creator>Hirohashi, Masami</creator><creator>Nagatomo, Hiroko</creator><creator>Yamato, Hiroshi</creator><creator>Akiyama, Izumi</creator><creator>Hori, Hajime</creator><creator>Higashi, Toshiaki</creator><creator>Tanaka, Isamu</creator><general>JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope><scope>NAPCQ</scope></search><sort><creationdate>200309</creationdate><title>Gene Expression of Surfactant Protein-A and Thyroid Transcription Factor-1 in Lungs of Rats Exposed to Silicon-Carbide Whisker in vivo</title><author>Morimoto, Yasuo ; Ding, Li ; Oyabu, Takako ; Kim, Heungnam ; Ogami, Akira ; Hirohashi, Masami ; Nagatomo, Hiroko ; Yamato, Hiroshi ; Akiyama, Izumi ; Hori, Hajime ; Higashi, Toshiaki ; Tanaka, Isamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6616-9d859fe1749394b48ff154c850307f1924b7948bd5e3875aba4354974f7d44273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Asbestos</topic><topic>Gene Expression</topic><topic>Lung</topic><topic>Lung Diseases - pathology</topic><topic>Lungs</topic><topic>Nuclear Proteins - genetics</topic><topic>Occupational health</topic><topic>Proteins</topic><topic>Pulmonary Surfactant-Associated Protein A - genetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Rodents</topic><topic>RT‐PCR</topic><topic>Silicon</topic><topic>Silicon carbide whisker</topic><topic>Silicon Compounds - toxicity</topic><topic>SP‐A</topic><topic>SP‐C</topic><topic>Statistics, Nonparametric</topic><topic>Surfactants</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Nuclear Factor 1</topic><topic>Transcription factors</topic><topic>Transcription Factors - genetics</topic><topic>Transcription, Genetic</topic><topic>TTF‐1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morimoto, Yasuo</creatorcontrib><creatorcontrib>Ding, Li</creatorcontrib><creatorcontrib>Oyabu, Takako</creatorcontrib><creatorcontrib>Kim, Heungnam</creatorcontrib><creatorcontrib>Ogami, Akira</creatorcontrib><creatorcontrib>Hirohashi, Masami</creatorcontrib><creatorcontrib>Nagatomo, Hiroko</creatorcontrib><creatorcontrib>Yamato, Hiroshi</creatorcontrib><creatorcontrib>Akiyama, Izumi</creatorcontrib><creatorcontrib>Hori, Hajime</creatorcontrib><creatorcontrib>Higashi, Toshiaki</creatorcontrib><creatorcontrib>Tanaka, Isamu</creatorcontrib><creatorcontrib>School of Health Sciences</creatorcontrib><creatorcontrib>Institute of Industrial and Ecological Sciences</creatorcontrib><creatorcontrib>Japan</creatorcontrib><creatorcontrib>University of Occupational and Environmental Health</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of Occupational Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morimoto, Yasuo</au><au>Ding, Li</au><au>Oyabu, Takako</au><au>Kim, Heungnam</au><au>Ogami, Akira</au><au>Hirohashi, Masami</au><au>Nagatomo, Hiroko</au><au>Yamato, Hiroshi</au><au>Akiyama, Izumi</au><au>Hori, Hajime</au><au>Higashi, Toshiaki</au><au>Tanaka, Isamu</au><aucorp>School of Health Sciences</aucorp><aucorp>Institute of Industrial and Ecological Sciences</aucorp><aucorp>Japan</aucorp><aucorp>University of Occupational and Environmental Health</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene Expression of Surfactant Protein-A and Thyroid Transcription Factor-1 in Lungs of Rats Exposed to Silicon-Carbide Whisker in vivo</atitle><jtitle>Journal of Occupational Health</jtitle><addtitle>J Occup Health</addtitle><date>2003-09</date><risdate>2003</risdate><volume>45</volume><issue>5</issue><spage>307</spage><epage>312</epage><pages>307-312</pages><issn>1341-9145</issn><issn>1348-9585</issn><eissn>1348-9585</eissn><abstract>Gene Expression of Surfactant Protein-A and Thyroid Transcription Factor-1 in Lungs of Rats Exposed to Silicon-Carbide Whisker in vivo : Yasuo MORIMOTO, et al. Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health-Intratracheal instillation studies have shown that exposure to silicon carbide whisker (SiCW), an asbestos substitute, produces pulmonary fibrotic changes, suggesting that SICW might have a fibrogenic potential. It is thought that surfactant protein is a good biomarker of lung injury and pulmonary fibrotic activity. In order to explore whether or not surfactant protein is associated with lung disorder through exposure to SiCW, we examined the expression of SP-A, SP-C and thyroid transcription factor-1 (TTF-1 ), a common transcription factor of SP-A and SP-C mRNA in lungs exposed to SiCW. Male Wistar rats were administered 2 mg or 10 mg of SiCW suspended in saline by a single intratracheal instillation, and were sacrificed at 3 d, 1 wk, 1 month, 3 months and 6 months after the intratracheal instillation. RNA was subsequently extracted from the lungs, and expression of SP-A, SP-C and TTF-1 mRNA from the lungs was observed by reverse transcription-polymerase chain reaction (RT-PCR). Exposure to 2 mg of SiCW showed a decrease in mRNA of SP-A and TTF-1 at 6 months, but exposure to 10 mg of SiCW showed decreased levels of SP-A and TTF-1 mRNA at 3 d and 6 months. On the other hand, 2 mg of SiCW increased the level of SP-C mRNA from 3 d to 3 months, and 10 mg of SiCW decreased the levels of SP-C mRNA in the rat lungs at 3 d, 1 month and 6 months. No clear tendency to the expression of SP-C was observed, but the patterns of expression of TTF-1 and SP-A were similar. These data suggest that SP-A and TTF-1 are associated with not only the acute phase but also the chronic phase in lungs exposed to SiCW. (J Occup Health 2003 ; 45 : 307-3 12)</abstract><cop>Australia</cop><pub>JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</pub><pmid>14646272</pmid><doi>10.1539/joh.45.307</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Open Access Collection; J-STAGE Free; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Asbestos Gene Expression Lung Lung Diseases - pathology Lungs Nuclear Proteins - genetics Occupational health Proteins Pulmonary Surfactant-Associated Protein A - genetics Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Rodents RT‐PCR Silicon Silicon carbide whisker Silicon Compounds - toxicity SP‐A SP‐C Statistics, Nonparametric Surfactants Thyroid Thyroid gland Thyroid Nuclear Factor 1 Transcription factors Transcription Factors - genetics Transcription, Genetic TTF‐1 |
| title | Gene Expression of Surfactant Protein-A and Thyroid Transcription Factor-1 in Lungs of Rats Exposed to Silicon-Carbide Whisker in vivo |
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