Developmental lead exposure alters mitochondrial monoamine oxidase and synaptosomal catecholamine levels in rat brain

Rats were lactationally exposed to low‐ (0.2%) and high‐level (1%) lead (Pb) from postnatal day 1 (PND1) through PND21 through the drinking water of the mother. The levels of catecholamines, epinephrine, norepinephrine and dopamine and the activity of the enzyme monoamine oxidase (MAO) were determin...

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Veröffentlicht in:	International journal of developmental neuroscience 2005-06, Vol.23 (4), p.375-381
Hauptverfasser:	Devi, C.B., Reddy, G.H., Prasanthi, R.P.J., Chetty, C.S., Reddy, G.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - drug effects Aging - metabolism Animals Animals, Newborn Brain - drug effects Brain - metabolism Catecholamines Catecholamines - metabolism Cerebellum Cortex Dose-Response Relationship, Drug Gene Expression Regulation, Developmental - drug effects Hippocampus Lead Lead - administration & dosage Lead Poisoning, Nervous System, Childhood - etiology Lead Poisoning, Nervous System, Childhood - metabolism Male Mitochondria - drug effects Mitochondria - enzymology Monoamine oxidase Monoamine Oxidase - metabolism Rats Rats, Wistar Synaptosomes - drug effects Synaptosomes - metabolism Tissue Distribution - drug effects
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