RAS transformation causes sustained activation of epidermal growth factor receptor and elevation of mitogen‐activated protein kinase in human mammary epithelial cells

Activation of the ras oncogene is an important step in carcinogenesis. Human MCF‐10A mammary epithelial cells were transformed with a point‐mutated form of the Ha‐ras oncogene. Epidermal growth factor receptor (EGFR) phosphorylation levels were chronically elevated after EGF induction and the EGFR l...

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Veröffentlicht in:	International journal of cancer 2000-10, Vol.88 (1), p.44-52
Hauptverfasser:	Martínez‐Lacaci, Isabel, Kannan, Subha, De Santis, Marta, Bianco, Caterina, Kim, Nancy, Wallace‐Jones, Brenda, Ebert, Andreas D., Wechselberger, Christian, Salomon, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibody Specificity Biological and medical sciences Breast - enzymology Breast - metabolism Breast - pathology Cell Line, Transformed Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cells, Cultured Enzyme Activation Enzyme Inhibitors - pharmacology Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacokinetics ErbB Receptors - genetics ErbB Receptors - metabolism ErbB Receptors - physiology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes, ras - genetics Genes, ras - physiology Growth Inhibitors - pharmacology Ha-ras gene Humans MAP Kinase Signaling System - physiology mitogen-activated protein kinase Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - biosynthesis Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - biosynthesis Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology Phosphorylation Point Mutation Proto-Oncogene Proteins c-raf - genetics Proto-Oncogene Proteins c-raf - metabolism Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Subcellular Fractions - enzymology Substrate Specificity Transfection
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