Prevention of Neomycin-induced Nephrotoxic Event in Pig Proximal Tubular Epithelial Cell Line by Apolipoprotein E3
Nephrotoxicity is one of critical problems of aminoglycoside antibiotics. We examined the protective effect of apolipoprotein E3 (apoE3), one of ligands for megalin, on neomycin-induced extracellular release of lactate dehydrogenase, a marker of cell necrosis using pig proximal tubular LLC-PK 1 cell...
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| Veröffentlicht in: | Journal of antibiotics 2005-05, Vol.58 (5), p.353-355 |
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| container_end_page | 355 |
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| container_title | Journal of antibiotics |
| container_volume | 58 |
| creator | Takamoto, Kozo Kawada, Manabu Ikeda, Daishiro |
| description | Nephrotoxicity is one of critical problems of aminoglycoside antibiotics. We examined the protective effect of apolipoprotein E3 (apoE3), one of ligands for megalin, on neomycin-induced extracellular release of lactate dehydrogenase, a marker of cell necrosis using pig proximal tubular LLC-PK
1
cells. Neomycin significantly induced the extracellular release of lactate dehydrogenase, but apoE3 successfully suppressed it. This result indicated that apoE3 protects the proximal tubular cells from the eventual cell death induced by nephrotoxic aminoglycosides. |
| doi_str_mv | 10.1038/ja.2005.45 |
| format | Article |
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1
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cells. Neomycin significantly induced the extracellular release of lactate dehydrogenase, but apoE3 successfully suppressed it. This result indicated that apoE3 protects the proximal tubular cells from the eventual cell death induced by nephrotoxic aminoglycosides.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - antagonists & inhibitors</subject><subject>Anti-Bacterial Agents - toxicity</subject><subject>Antibiotics</subject><subject>Apolipoprotein E3</subject><subject>Apolipoproteins E - pharmacology</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Cell Line</subject><subject>Dehydrogenase</subject><subject>Epithelial Cells - enzymology</subject><subject>Epithelial Cells - pathology</subject><subject>Extracellular Space - enzymology</subject><subject>Extracellular Space - metabolism</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - enzymology</subject><subject>Kidney Tubules, Proximal - enzymology</subject><subject>Kidney Tubules, Proximal - pathology</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Life Sciences</subject><subject>LLC-PK1 Cells</subject><subject>Medicinal Chemistry</subject><subject>Microbiology</subject><subject>Neomycin - antagonists & inhibitors</subject><subject>Neomycin - toxicity</subject><subject>Organic Chemistry</subject><subject>Swine</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkU9rGzEQxUVpaJy0l36AICj00LKOtNrVn6MxbhIwiQ_ueZF3Zx2ZtbSRdkP87TvGhpbmNPD0m_dGM4R85WzKmdC3OzvNGSunRfmBTLjWPOOFNB_JhLGcZ1rn7JJcpbRjTCih9CdyySWT2GkmJK4ivIIfXPA0tPQRwv5QO58534w1NCj0zzEM4c3VdHEEqfN05bZ0FVHb246ux83Y2UgXvRueoXMozaHr6NJ5oJsDnfWhc33o0QWwdyE-k4vWdgm-nOs1-f1rsZ7fZ8unu4f5bJnVhSmGzIIu2pZLrUpjG6UKEFwaY_A7G1ljsUI0WmlhpcwVlLwp2lw1uhZaGY30Nfl-8sXolxHSUO1dqnE06yGMqeKqVCLXBsFv_4G7MEaPsyFzTBBMcqR-nKg6hpQitFUfcQHxUHFWHe9Q7Wx1vENVlAjfnC3HzR6av-h58Qj8PAEJn_wW4j-Z7-3-AHoDkEU</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Takamoto, Kozo</creator><creator>Kawada, Manabu</creator><creator>Ikeda, Daishiro</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7T7</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20050501</creationdate><title>Prevention of Neomycin-induced Nephrotoxic Event in Pig Proximal Tubular Epithelial Cell Line by Apolipoprotein E3</title><author>Takamoto, Kozo ; 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| subjects | Animals Anti-Bacterial Agents - antagonists & inhibitors Anti-Bacterial Agents - toxicity Antibiotics Apolipoprotein E3 Apolipoproteins E - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cell Line Dehydrogenase Epithelial Cells - enzymology Epithelial Cells - pathology Extracellular Space - enzymology Extracellular Space - metabolism Kidney Diseases - chemically induced Kidney Diseases - enzymology Kidney Tubules, Proximal - enzymology Kidney Tubules, Proximal - pathology L-Lactate Dehydrogenase - metabolism Life Sciences LLC-PK1 Cells Medicinal Chemistry Microbiology Neomycin - antagonists & inhibitors Neomycin - toxicity Organic Chemistry Swine |
| title | Prevention of Neomycin-induced Nephrotoxic Event in Pig Proximal Tubular Epithelial Cell Line by Apolipoprotein E3 |
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