Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator

Cellular glycosphingolipid (GSL) storage is known to promote cholesterol accumulation. Although physical interactions between GSLs and cholesterol are thought to cause intracellular cholesterol "trapping," it is not known whether cholesterol homeostatic mechanisms are also impaired under t...

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Veröffentlicht in:	The Journal of biological chemistry 2005-07, Vol.280 (26), p.24515-24523
Hauptverfasser:	Glaros, Elias N, Kim, Woojin Scott, Quinn, Carmel M, Wong, Jenny, Gelissen, Ingrid, Jessup, Wendy, Garner, Brett
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Deoxynojirimycin - analogs & derivatives 1-Deoxynojirimycin - pharmacology Antigens, CD - metabolism Apolipoprotein A-I - chemistry ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - chemistry Biotinylation Blotting, Western Cell Line Cell Membrane - metabolism Cholesterol - metabolism Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Fibroblasts - metabolism Glycosphingolipids - metabolism Humans Lactosylceramides - metabolism Lipoproteins, LDL - chemistry Monocytes - metabolism Morpholines - chemistry Morpholines - pharmacology Phospholipids - chemistry Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Time Factors Up-Regulation
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