The biochemistry of Parkinson's disease

Several genes have been identified for monogenic disorders that variably resemble Parkinson's disease. Dominant mutations in the gene encoding alpha-synuclein enhance the propensity of this protein to aggregate. As a consequence, these patients have a widespread disease with protein inclusion b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annual review of biochemistry 2005-01, Vol.74 (1), p.29-52
1. Verfasser:	Cookson, Mark R
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein Biochemistry Genes Genes, Recessive Genotype & phenotype Humans Intracellular Signaling Peptides and Proteins Mitochondrial DNA Models, Biological Multiprotein Complexes Mutation Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Oncogene Proteins - chemistry Oncogene Proteins - genetics Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson's disease Phenotype Proteasome Endopeptidase Complex - chemistry Proteasome Endopeptidase Complex - genetics Protein Deglycase DJ-1 Protein Kinases - chemistry Protein Kinases - genetics Proteins Synucleins Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!