Low levels of sarin affect the eeg in marmoset monkeys: a pilot study

The main purpose of this pilot study was to estimate the lowest observable adverse effect level (LOAEL) for the electroencephalogram (EEG) upon long‐term, low‐level exposure of vehicle‐pretreated and pyridostigmine‐pretreated marmoset monkeys to sarin vapour. This is the C·t value (t = 5 h) of expos...

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Veröffentlicht in:	Journal of applied toxicology 2004-11, Vol.24 (6), p.475-483
Hauptverfasser:	van Helden, Herman P. M., Vanwersch, Raymond A. P., Kuijpers, Willem C., Trap, Henk C., Philippens, Ingrid H. C., Benschop, Hendrik P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Callithrix - physiology Chemical and industrial products toxicology. Toxic occupational diseases Chemical Warfare Agents - toxicity Cholinesterase Inhibitors - administration & dosage Cholinesterase Inhibitors - pharmacology Dose-Response Relationship, Drug EEG Electroencephalography - drug effects exposure limits Female Gas, fumes Humans Inhalation Exposure lowest observable adverse effect level (LOAEL) Male Medical sciences nerve agent O-isopropyl methylphosphonoﬂuoridate pyridostigmine Pyridostigmine Bromide - administration & dosage Pyridostigmine Bromide - pharmacology sarin Sarin - administration & dosage Sarin - toxicity sleep-spindles Time Factors Toxicology whole-body exposure ﬁeld alarm
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