The Decrease in the Presynaptic Calcium Current Is a Major Cause of Short-Term Depression at a Calyx-Type Synapse

Repetitive nerve firings cause short-term depression (STD) of release at many synapses. Its underlying mechanism is largely attributed to depletion of a readily releasable vesicle pool (RRP) and a decreased probability of releasing a readily releasable vesicle during an action potential. Which of th...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2005-05, Vol.46 (4), p.633-645
Hauptverfasser:	Xu, Jianhua, Wu, Ling-Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Action Potentials - radiation effects Animals Animals, Newborn Barium - pharmacology Brain Stem - cytology Calcium - metabolism Calcium Channels - drug effects Calcium Channels - metabolism Calcium Channels - radiation effects Chelating Agents - pharmacology CREB-Binding Protein Dose-Response Relationship, Radiation Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Electric Capacitance Electric Stimulation - methods Enzyme Inhibitors - pharmacology Hypotheses Imidazoles - pharmacology In Vitro Techniques Models, Biological Neural Inhibition - drug effects Neural Inhibition - physiology Neural Inhibition - radiation effects Nuclear Proteins - pharmacology Patch-Clamp Techniques - methods Peptides - pharmacology Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Rats Rats, Wistar Synapses - metabolism Time Factors Trans-Activators - pharmacology
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