The Decrease in the Presynaptic Calcium Current Is a Major Cause of Short-Term Depression at a Calyx-Type Synapse

Repetitive nerve firings cause short-term depression (STD) of release at many synapses. Its underlying mechanism is largely attributed to depletion of a readily releasable vesicle pool (RRP) and a decreased probability of releasing a readily releasable vesicle during an action potential. Which of th...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2005-05, Vol.46 (4), p.633-645
Hauptverfasser: Xu, Jianhua, Wu, Ling-Gang
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container_title Neuron (Cambridge, Mass.)
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Wu, Ling-Gang
description Repetitive nerve firings cause short-term depression (STD) of release at many synapses. Its underlying mechanism is largely attributed to depletion of a readily releasable vesicle pool (RRP) and a decreased probability of releasing a readily releasable vesicle during an action potential. Which of these two mechanisms is dominant and the mechanism that decreases the release probability remain debated. Here, we report that a decreased release probability is caused by a calcium-induced inhibition of presynaptic calcium channels, particularly P/Q-type channels at the calyx of Held in rat brainstem. This mechanism was the dominant cause of STD in a wide range of stimulation conditions, such as during 2 to 20 action potential-equivalent stimuli (AP-e) at 0.2–30 Hz and after 2 to 20 AP-e at 0.2–100 Hz. Only during ≥100 Hz AP-e was depletion the dominant mechanism.
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subjects Action Potentials - drug effects
Action Potentials - physiology
Action Potentials - radiation effects
Animals
Animals, Newborn
Barium - pharmacology
Brain Stem - cytology
Calcium - metabolism
Calcium Channels - drug effects
Calcium Channels - metabolism
Calcium Channels - radiation effects
Chelating Agents - pharmacology
CREB-Binding Protein
Dose-Response Relationship, Radiation
Egtazic Acid - analogs & derivatives
Egtazic Acid - pharmacology
Electric Capacitance
Electric Stimulation - methods
Enzyme Inhibitors - pharmacology
Hypotheses
Imidazoles - pharmacology
In Vitro Techniques
Models, Biological
Neural Inhibition - drug effects
Neural Inhibition - physiology
Neural Inhibition - radiation effects
Nuclear Proteins - pharmacology
Patch-Clamp Techniques - methods
Peptides - pharmacology
Presynaptic Terminals - drug effects
Presynaptic Terminals - metabolism
Rats
Rats, Wistar
Synapses - metabolism
Time Factors
Trans-Activators - pharmacology
title The Decrease in the Presynaptic Calcium Current Is a Major Cause of Short-Term Depression at a Calyx-Type Synapse
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