Retention of the Cis Proline Conformation in Tripeptide Fragments of Bovine Pancreatic Ribonuclease A Containing a Non-natural Proline Analogue, 5,5-Dimethylproline

Attention is focused on l-5,5-dimethylproline (dmP) as a substitute to lock l-proline (Pro) in a cis conformation in peptides and proteins, to prevent cis/trans isomerization when a protein with cis X-Pro peptide groups unfolds. Procedures have been developed to obtain optically pure l-dmP and to in...

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Veröffentlicht in:	Journal of the American Chemical Society 1999-12, Vol.121 (49), p.11558-11566
Hauptverfasser:	An, Seong Soo A, Lester, Cathy C, Peng, Jin-Lin, Li, Yue-Jin, Rothwarf, David M, Welker, Ervin, Thannhauser, Theodore W, Zhang, L. S, Tam, James P, Scheraga, Harold A
Format:	Artikel
Sprache:	eng
Schlagworte:	5,5,-dimethylproline
Online-Zugang:	Volltext
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