Corneal opacity, hydration and endothelial morphology in the bovine cornea opacity and permeability assay using reduced treatment times

The purpose of this study was to determine whether the standard bovine cornea opacity and permeability (BCOP) assay exposure time of 10 minutes overestimates the ocular irritancy of chemical substances. Corneas were subjected to BCOP protocol following 30-second and 1-minute exposures to irritants....

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Veröffentlicht in:	Toxicology in vitro 2000-08, Vol.14 (4), p.379-386
Hauptverfasser:	Ubels, J.L, Pruis, R.M, Sybesma, J.T, Casterton, P.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthraquinones Biological and medical sciences Body Water - metabolism bovine cornea opacity and permeable assay bovine corneal opacity and permeability assay Cattle Cell Death - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Coloring Agents cornea, corneal endothelium Corneal Opacity - chemically induced Corneal Opacity - metabolism Corneal Opacity - pathology corneal stroma Endothelium, Corneal - drug effects Endothelium, Corneal - metabolism Endothelium, Corneal - pathology Irritants - toxicity Medical sciences Permeability - drug effects Sodium Hydroxide - toxicity Staining and Labeling Time Factors Toxicology Trichloroacetic Acid - toxicity Trypan Blue Various organic compounds
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