Molecular Mechanisms of Tumor Necrosis Factor α Gene Expression in Monocytic Cells via Hyperglycemia-induced Oxidant Stress-dependent and -independent Pathways

Increased oxidative stress has been reported in vivo in the diabetic state via the production of reactive oxygen species (ROS). Such stress is bound to play a key role on activation of circulating monocytes, leading to the accelerated atherosclerosis observed in diabetics. However the exact molecula...

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Veröffentlicht in:	The Journal of biological chemistry 2000-06, Vol.275 (23), p.17728-17739
Hauptverfasser:	Guha, Mausumee, Bai, Wei, Nadler, Jerry L., Natarajan, Rama
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Cell Line Gene Expression Regulation - drug effects Gene Expression Regulation - physiology glucose Glucose - pharmacology Humans Hyperglycemia Imidazoles - pharmacology luciferase Luminescent Measurements Mitogen-Activated Protein Kinases - antagonists & inhibitors Monocytes - physiology NF-^KB protein NF-kappa B - metabolism Oxidative Stress - physiology p38 Mitogen-Activated Protein Kinases Proline - analogs & derivatives Proline - pharmacology Pyridines - pharmacology Reactive Oxygen Species - physiology RNA, Messenger - genetics Thiocarbamates - pharmacology Transcription Factor AP-1 - metabolism Transcription, Genetic - drug effects tumor necrosis factor-^a Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - pharmacology U937 Cells
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